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DOI: 10.1055/s-0040-1721362
Serum Levels of Vitamin D in Children with or without Isolated Distal Radius Fractures: A Prospective Clinical Study[*]
Artikel in mehreren Sprachen: português | English![](https://www.thieme-connect.de/media/10.1055-s-00042410/202103/lookinside/thumbnails/10-1055-s-0040-1721362_2000079_en-1.jpg)
Abstract
Objective To compare the serum levels of vitamin D and minerals in children with or without isolated distal radius fractures.
Methods The present prospective clinical study included 50 children (aged between 5 and 15 years) with isolated distal radius fractures who were admitted to our emergency unit between February and May 2018 as the study group (group A), and 50 healthy children with no history of fracture as the control group (group B). Peripheral venous blood samples were obtained and analyzed for measurements of 25-hydroxyvitamin D (25(OH)D), calcium (Ca), magnesium (Mg), phosphorus (P), alkaline phosphatase (ALP), and parathyroid hormone (PTH) in both groups. Patient characteristics and peripheral venous blood samples were compared between the groups.
Results The mean age, height, weight, body mass index (BMI) and gender distribution were similar in both groups. There were no statistical differences in the blood analyses, including Ca, Mg, P, ALP, and PTH. However, the serum levels of 25(OH)D were statistically lower in group A when compared to group B (p < 0.001), and the number of patients with 25(OH)D insufficiency was statistically higher in group A than in group B (p = 0.012).
Conclusion Children with isolated distal radius fracture should be informed about vitamin D deficiency, and, in children with low levels of vitamin D, supplementation may be considered.
* Work developed at the Department of Orthopedic Surgery and Traumatology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
Publikationsverlauf
Eingereicht: 31. März 2020
Angenommen: 17. September 2020
Artikel online veröffentlicht:
31. März 2021
© 2020. Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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Referências
- 1 Nellans KW, Kowalski E, Chung KC. The epidemiology of distal radius fractures. Hand Clin 2012; 28 (02) 113-125
- 2 Khosla S, Melton 3rd LJ, Dekutoski MB, Achenbach SJ, Oberg AL, Riggs BL. Incidence of childhood distal forearm fractures over 30 years: a population-based study. JAMA 2003; 290 (11) 1479-1485
- 3 Hagino H, Yamamoto K, Ohshiro H, Nose T. Increasing incidence of distal radius fractures in Japanese children and adolescents. J Orthop Sci 2000; 5 (04) 356-360
- 4 Mathison DJ, Agrawal D. An update on the epidemiology of pediatric fractures. Pediatr Emerg Care 2010; 26 (08) 594-603 , quiz 604–606
- 5 Wren TA, Shepherd JA, Kalkwarf HJ. et al. Racial disparity in fracture risk between white and nonwhite children in the United States. J Pediatr 2012; 161 (06) 1035-1040
- 6 Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med 2004; 116 (09) 634-639
- 7 Myburgh KH, Hutchins J, Fataar AB, Hough SF, Noakes TD. Low bone density is an etiologic factor for stress fractures in athletes. Ann Intern Med 1990; 113 (10) 754-759
- 8 Goulding A, Jones IE, Taylor RW, Williams SM, Manning PJ. Bone mineral density and body composition in boys with distal forearm fractures: a dual-energy x-ray absorptiometry study. J Pediatr 2001; 139 (04) 509-515
- 9 Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 1999; 69 (04) 727-736
- 10 Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008; 122 (02) 398-417
- 11 Bowden SA, Robinson RF, Carr R, Mahan JD. Prevalence of vitamin D deficiency and insufficiency in children with osteopenia or osteoporosis referred to a pediatric metabolic bone clinic. Pediatrics 2008; 121 (06) e1585-e1590
- 12 Flynn JM, Jones KJ, Garner MR, Goebel J. Eleven years experience in the operative management of pediatric forearm fractures. J Pediatr Orthop 2010; 30 (04) 313-319
- 13 Landin LA. Epidemiology of children's fractures. J Pediatr Orthop B 1997; 6 (02) 79-83
- 14 Chung KC, Spilson SV. The frequency and epidemiology of hand and forearm fractures in the United States. J Hand Surg Am 2001; 26 (05) 908-915
- 15 Ryan LM, Teach SJ, Searcy K. et al. Epidemiology of pediatric forearm fractures in Washington, DC. J Trauma 2010; 69 (4, Suppl): S200-S205
- 16 Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006; 81 (03) 353-373
- 17 Holick MF, Binkley NC, Bischoff-Ferrari HA. et al. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96 (07) 1911-1930
- 18 Moore CE, Murphy MM, Holick MF. Vitamin D intakes by children and adults in the United States differ among ethnic groups. J Nutr 2005; 135 (10) 2478-2485
- 19 Goulding A, Cannan R, Williams SM, Gold EJ, Taylor RW, Lewis-Barned NJ. Bone mineral density in girls with forearm fractures. J Bone Miner Res 1998; 13 (01) 143-148
- 20 Arya V, Bhambri R, Godbole MM, Mithal A. Vitamin D status and its relationship with bone mineral density in healthy Asian Indians. Osteoporos Int 2004; 15 (01) 56-61
- 21 Outila TA, Kärkkäinen MU, Lamberg-Allardt CJ. Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density. Am J Clin Nutr 2001; 74 (02) 206-210
- 22 Liberman UA, Weiss SR, Bröll J. et al. The Alendronate Phase III Osteoporosis Treatment Study Group. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med 1995; 333 (22) 1437-1443
- 23 Schuit SC, van der Klift M, Weel AE. et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 2004; 34 (01) 195-202
- 24 Johnston Jr CC, Miller JZ, Slemenda CW. et al. Calcium supplementation and increases in bone mineral density in children. N Engl J Med 1992; 327 (02) 82-87
- 25 Marwaha RK, Tandon N, Reddy DR. et al. Vitamin D and bone mineral density status of healthy schoolchildren in northern India. Am J Clin Nutr 2005; 82 (02) 477-482
- 26 Guillemant J, Taupin P, Le HT. et al. Vitamin D status during puberty in French healthy male adolescents. Osteoporos Int 1999; 10 (03) 222-225
- 27 Ford JA, Colhoun EM, McIntosh WB, Dunnigan MG. Rickets and osteomalacia in the Glasgow Pakistani community, 1961-71. BMJ 1972; 2 (5815): 677-680
- 28 Goswami R, Gupta N, Goswami D, Marwaha RK, Tandon N, Kochupillai N. Prevalence and significance of low 25-hydroxyvitamin D concentrations in healthy subjects in Delhi. Am J Clin Nutr 2000; 72 (02) 472-475
- 29 Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int 2005; 16 (07) 713-716