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DOI: 10.1055/s-0040-1721421
Neonatal Survivability following Previable PPROM after Hospital Readmission for Intervention
Autoren
Funding Information No funding was received for this study. Organizational support was provided by Woman's Hospital, Baton Rouge, LA and Department of Obstetrics and Gynecology, Louisiana State University Health and Sciences Center, Baton Rouge, LA.
Abstract
Objective To describe our hospital's experience following expectant management of previable preterm prelabor rupture of membranes (pPPROM).
Study Design Retrospective review of neonatal survival and maternal and neonatal outcomes of pPPROM cases between 2012 and 2019 at a tertiary referral center in South Central Louisiana. Regression analyses were performed to identify predictors of neonatal survival.
Results Of 81 cases of pPPROM prior to 23 weeks gestational age (WGA), 23 survived to neonatal intensive care unit discharge (28.3%) with gestational age at rupture ranging from 180/7 to 226/7 WGA. Increased latency (adjusted odds ratio [aOR] = 1.30, 95% confidence interval [CI] = 1.11, 1.52) and increased gestational age at rupture (aOR = 1.62, 95% CI = 1.19, 2.21) increased the probability of neonatal survival. Antibiotics prior to delivery were associated with increased latency duration (adjusted hazard ratio = 0.55, 95% CI = 0.42, 0.74).
Conclusion Neonatal survival rate following pPPROM was 28.3%. Later gestational age at membrane rupture and increased latency periods are associated with increased neonatal survivability. Antibiotic administration following pPPROM increased latency duration.
Authors' Contribution
F.A.M., R.C.M., and F.L. conceptualized and designed the study. F.L. collected the data. A.C. analyzed the data. F.L. and E.S. interpreted data and drafted the manuscript. All authors were involved in the review, revision, and editing of the final manuscript.
Publikationsverlauf
Eingereicht: 30. Januar 2020
Angenommen: 29. April 2020
Artikel online veröffentlicht:
03. Dezember 2020
© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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