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CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2021; 40(02): e137-e145
DOI: 10.1055/s-0040-1722246
Original Article | Artigo Original

Can Routine Blood Biochemistry Parameters be Predictive Prognostic Marker(s) in Operated Patients with Meningioma WHO Grade 1?

Ulas Yuksel 
1   Department of Neurosurgery, Kirikkale University Faculty of Medicine, Kirikkale, Turkey
,
Alemiddin Ozdemir 
1   Department of Neurosurgery, Kirikkale University Faculty of Medicine, Kirikkale, Turkey
,
Ucler Kisa 
2   Department of Biochemistry, Kirikkale University Faculty of Medicine, Kirikkale, Turkey
,
Mustafa Ogden 
1   Department of Neurosurgery, Kirikkale University Faculty of Medicine, Kirikkale, Turkey
,
Bulent Bakar 
1   Department of Neurosurgery, Kirikkale University Faculty of Medicine, Kirikkale, Turkey
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Abstract

Background Today, there is a need for new and independent additional advanced markers that can predict the prognosis of meningioma patients, postoperatively. The present study aimed to find out postoperative short-term prognostic markers in patients with meningioma using their demographic data and routine blood biochemistry findings evaluated preoperatively.

Methods The Glasgow Coma Scale (GCS), and Glasgow Outcome Scale (GOS) scores of the patients were recorded. Additionally, preoperatively obtained serum glucose, C-reactive protein (CRP), sodium, potassium, creatinine, blood urea nitrogen, aspartate aminotransferase (AST), alanine aminotransferase, and hemoglobin level values, platelet, leukocyte, neutrophil, lymphocyte, eosinophil, basophil, and monocyte count results, erythrocyte sedimentation rate (ESR), neutrophil-lymphocyte ratio, platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) values were evaluated.

Results In the present study, 23 operated patients with meningioma World Health Organization (WHO) grade 1 (17 females, 6 males) were included. Correlation test results revealed that the GCS score, platelet count, and serum potassium level values could directly predict the short-term prognosis of these patients. Additionally, these test results suggested that the lymphocyte, monocyte, and eosinophil count values, PLR, LMR, ESR, serum glucose, CRP, and AST level values could be indirect markers in predicting the short-term prognosis. However, likelihood ratio test results revealed that only monocyte count value, LMR value, and serum CRP level value could be the markers for prediction of the short-term prognosis.

Conclusion At the end of the present study, it was concluded that the monocyte count value, LMR value, and serum CRP level value could be the best markers in predicting the short-term prognosis of the operated meningioma patients.

Keywords

biochemistry - biomarker - meningioma - prognosis

Financial Disclosure Statements

The authors declare that they have not engaged in any financial relationship with any company whose product might be affected by the research described or with any company that makes or markets a competing product.


Informed Consent

Since the present study had a retrospective character, the patients were informed that their information could be used in the study on the condition of protecting their personal information, and consent was obtained, so no additional consent was obtained.




Publication History

Received: 08 August 2020

Accepted: 16 November 2020

Article published online:
18 January 2021

© 2021. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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