Combination Immunotherapy for Hepatocellular Carcinoma: Where Are We Currently?

Pedro Luiz Serrano Uson Junior; Bolni Marius Nagalo; Daniel H. Ahn; Tanios Bekaii-Saab; Mitesh J. Borad

doi:10.1055/s-0040-1722646

Seminars in Liver Disease, Table of Contents

Semin Liver Dis 2021; 41(02): 136-141
DOI: 10.1055/s-0040-1722646

Review Article

Combination Immunotherapy for Hepatocellular Carcinoma: Where Are We Currently?

Pedro Luiz Serrano Uson Junior

¹Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona

²Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota

³Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, Arizona

,

Bolni Marius Nagalo

¹Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona

²Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota

³Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, Arizona

⁴Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota

,

Daniel H. Ahn

¹Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona

,

Tanios Bekaii-Saab

¹Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona

,

Mitesh J. Borad

¹Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona

²Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota

³Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, Arizona

⁴Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota

› Author Affiliations

Abstract

The past decade has seen a rise in the availability of breakthrough therapeutic strategies for treatment of hepatocellular carcinoma (HCC). A tumor microenvironment in HCC is regulated by various immunotolerance mechanisms; therefore, therapeutic strategies aiming at disrupting tumor immune tolerance are becoming attractive curative options in HCC. Immune checkpoint inhibitors have demonstrated impressive effectiveness in HCC, including in sorafenib-unresponsive patients. Synergistic approaches with checkpoint inhibitors (anti-PD-1/PD-L1 and CTLA-4) and antiangiogenic drugs are burgeoning as first-line treatment therapeutic modalities in HCC.

Keywords

hepatocellular carcinoma - liver - checkpoint inhibitors - anti-PD-1 - anti-CTLA-4

Full Text

References

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