Leberschäden durch pflanzliche Medikamente und Nahrungsergänzungsmittel

Zahlreiche pflanzliche Medikamente und Nahrungsergänzungsmittel sind mit Leberschäden unterschiedlicher Art assoziiert oder als deren Auslöser identifiziert worden. Diese alle zu kennen und im Falle einer klinischen Fragestellung bedenken zu können, ist kaum möglich, sodass man ähnlich wie bei synthetischen Arzneimitteln entsprechende Nachforschungen anstellen muss.

Schlüsselwörter

Leberschädigung - pflanzliche Arzneimittel - Phytotherapeutika - Nahrungsergänzungsmittel

Keywords

liver injury - herbal medicine - phytotherapeutics - dietary supplementation

• Literatur

• 1 Eardley S, Bishop FL, Prescott P et al. A systematic literature review of complementary and alternative medicine prevalence in EU. Forsch Komplementmed 2012; 19 (Suppl. 02) 18-28
• 2 Eisenberg DM, Davis RB, Ettner SL et al. Trends in alternative medicine use in the United States, 1990–1997: results of a follow-up national study. JAMA 1998; 280: 1569-1575
• 3 Vlietinck A, Pieters L, Apers S. Legal requirements for the quality of herbal substances and herbal preparations for the manufacturing of herbal medicinal products in the European Union. Planta Med 2009; 75: 683-688
• 4 Navarro VJ, Barnhart H, Bonkovsky HL et al. Liver injury from Herbals and Dietary Supplements in the US Drug Induced Liver Injury Network. Hepatology 2014; 60: 1399-1408
• 5 Aithal GP, Rawlins MD, Day CP. Clinical diagnostic scale: a useful tool in the evaluation of suspected hepatotoxic adverse drug reactions. J Hepatol 2000; 33: 949-952
• 6 Rochon J, Protiva P, Seeff LB et al. Drug-induced Liver Injury Network (DILIN): Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug-induced liver injury. Hepatology 2008; 48: 1175-1182
• 7 DeLeve LD, Shulman HM, McDonald GB. Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis 2002; 22: 27-42
• 8 Teschke R, Wolff A, Frenzel C, Schulze J. Review article: Herbal hepatotoxicity – an update on traditional Chinese medicine preparations. Aliment Pharmacol Ther 2014; 40: 32-50
• 9 Fau D, Lekehal M, Farrell G et al. Diterpenoids from germander, an herbal medicine, induce apoptosis in isolated rat hepatocytes. Gastroenterology 1997; 113: 1334-1346
• 10 European Medicines Agency. Public statement on Chelidonium majus L., herba. http://www.ema.europa.eu/docs/en_GB/document_library/Public_statement/2012/01/WC500120714.pdf Zugriff: 27.5.2015
• 11 Stickel F, Baumüller HM, Seitz KH et al. Hepatitis induced by Kava-Kava (Piper methysticum rhizoma). J Hepatol 2003; 39: 62-67
• 12 Sarma DN, Barrett ML, Chavez ML et al. Safety of green tea extracts. A systematic Review by the US Pharmacopeia. Drug Saf 2008; 31: 469-484
• 13 Stickel F, Kessebohm K, Weimann R, Seitz HK. Review of Liver Injury Associated with Dietary Supplements. Liver Int 2011; 31: 595-605
• 14 U.S. Food and Drug Administration. Lipokinetix. www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm172824.htm Zugriff: 13.5.2015
• 15 U. S. Food and Drug Administration. Recall – Firm Press Release. www.fda.gov/Safety/recalls/ucm145164.htm Zugriff: 13.5.2015
• 16 Roytman MM, Pörzgen P, Lee CL et al. Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro. Am J Gastroenterol 2014; 109: 1296-1298
• 17 Seeff LB, Bonkovsky HL, Navarro VJ, Wang G. Herbal products and the liver: a review of adverse effects and mechanisms. Gastroenterology 2015; 148: 517-532
• 18 Stickel F, Shouval D. Hepatotoxicity of herbal and dietary supplements: an update. Arch Toxicol 2015; DOI: 10.1007/s00204-015-1471-3.