Download PDF
Dtsch Med Wochenschr 2015; 140(16): 1213-1215
DOI: 10.1055/s-0041-103622
Klinischer Fortschritt
Kardiologie
© Georg Thieme Verlag KG Stuttgart · New York

Embolieprophylaxe bei Vorhofflimmern

Neue orale Antikoagulanzien und VorhofohrverschlussProphylaxis of thromboembolism in atrial fibrillation: new oral anticoagulants and left atrial appendage closure
Tobias Zeus
1   Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum Düsseldorf
,
Malte Kelm
1   Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum Düsseldorf
,
Christoph Bode
2   Klinik für Kardiologie und Angiologie I, Universitäts-Herzzentrum Freiburg – Bad Krozingen
› Author Affiliations
Further Information

Publication History

Publication Date:
11 August 2015 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Die Thromboembolieprophylaxe bei Vorhofflimmern/-flattern ist ein zentrales therapeutisches Element. Neben den neuen oralen Antikoagulanzien hat sich der Vorhofohroccluder als Alternative insbesondere bei hohem Blutungsrisiko etabliert.

Abstract

Thrombo-embolic prophylaxis is a key element within the therapy of atrial fibrillation/atrial flutter. Besides new oral anticoagulants the concept of left atrial appendage occlusion has approved to be a good alternative option, especially in patients with increased risk of bleeding.

Schlüsselwörter

Thromboembolieprophylaxe - Vorhofflimmern - Vorhofohroccluder

Keywords

thrombo-embolic prophylaxis - atrial fibrillation - left atrial appendage occluder
 

  • Literatur

  • 1 Ansell JE, Bakhru SH, Laulicht BE et al. Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban. N Engl J Med 2014; 371: 2141-2142
    CrossrefPubMedSearch in Google Scholar
  • 2 Camm AJ, Lip GY, De Caterina R et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation. An update of the 2010 ESC Guidelines for the management of atrial fibrillation Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J 2012; 33: 2719-2747
    PubMedSearch in Google Scholar
  • 3 Chao TF, Liu CJ, Wang KL et al. Should atrial fibrillation patients with 1 additional risk factor of the CHA2DS-VASc Score (beyond sex) receive oral anticoagulization?. J Am Coll Cardiol 2015; 65: 635-642
    CrossrefPubMedSearch in Google Scholar
  • 4 Deitelzweig SB, Jing Y, Swindle JP, Makenbaeva D. Reviewing a clinical decision aid for the selection of anticoagulation treatment in patients with nonvalvular atrial fibrillation: applications in a US managed care health plan database. Clin Ther 2014; 36: 1566-1573
    CrossrefPubMedSearch in Google Scholar
  • 5 Gloekler S, Shakir S, Doblies J et al. Early results of first versus second generation Amplatzer occluders for left atrial appendage closure in patients with atrial fibrillation. Clin Res Cardiol 2015; 104: 656-665
    CrossrefPubMedSearch in Google Scholar
  • 6 Holmes DR, Reddy VY, Turi ZG et al. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial. Lancet 2009; 374: 534-542
    CrossrefPubMedSearch in Google Scholar
  • 7 Kirchhof P, Ammentorp B, Darius H et al. Management of atrial fibrillation in seven European countries after the publication of the 2010 ESC Guidelines on atrial fibrillation: primary results of the PREvention oF thromboemolic events – European Registry in Atrial Fibrillation (PREFER in AF). Europace 2014; 16: 6-14
    CrossrefPubMedSearch in Google Scholar
  • 8 Kuramatsu JB, Gerner ST, Schellinger PD et al. Anticoagulant reversal, blood pressure levels, and anticoagulant resumption in patients with anticoagulation-related intracerebral hemorrhage. JAMA 2015; 313: 824-836
    CrossrefPubMedSearch in Google Scholar
  • 9 Meier B, Blaauw Y, Khattab AA et al. EHRA / EAPCI expert consensus statement on catheter-based left atrial appendage occlusion. Europace 2014; 16: 1397-1416
    CrossrefPubMedSearch in Google Scholar
  • 10 Reddy VY, Sievert H, Halperin J et al. Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial. JAMA 2014; 312: 1988-1998
    CrossrefPubMedSearch in Google Scholar
  • 11 Sardar P, Chatterjee S, Lavie CJ et al. Risk of major bleeding in different indications for new oral anticoagulants: insights from a meta-analysis of approved dosages from 50 randomized trials. Int J Cardiol 2015; 179: 279-287
    PubMedSearch in Google Scholar
  • 12 Thompson PL, Verheugt FW. Managing antithrombotic therapy in patients with both atrial fibrillation and coronary heart disease. Clin Ther 2014; 36: 1176-1181
    CrossrefPubMedSearch in Google Scholar