Q-Fieber

Zusammenfassung

Im Artikel werden kurz die wichtigsten neueren Erkenntnisse über die Erkrankung des Erregers Coxiella burnetii, das Q-Fieber, dargestellt. Neben neuen diagnostischen Parametern zur Verlaufsbeobachtung, werden auch die Bedeutung eines frühzeitigen Nachweises eines chronischen Q-Fiebers und die Besonderheiten des Post-Q-Fieber-Fatigue-Syndroms dargestellt.

Abstract

The article summarizes some important recently identified findings about the Coxiella burnetii disease, Q fever. Beside new diagnostic parameters for follow-up issues, the importance of a timely identification of chronic Q fever and the peculiarities of the post Q fever fatigue syndrome are depicted.

Schlüsselwörter

Q-Fieber - Coxiella burnetii - Interferon-gamma - Chronisches Q-Fieber - Post-Q-Fieber-Fatigue-Syndrom

Keywords

Q fever - coxiella burnetii - interferon-gamma - chronic Q fever - post Q fever fatigue syndrome

• Literatur

• 1 Fischer S, Kimmig P, Wagner-Wiening C, Frangoulidis D. Coxiella burnetii. In Zoonosen 2012; 33: 40-49
• 2 Pennings JLA, Kremers MNT, Hodemaekers HM et al. Dysregulation of serum interferon-γ levels in vascular chronic Q fever patients: insights into disease pathogenesis. Clin Vaccine Immunol 2015; 22: 664-671
• 3 Schoffelen T, Wegdam-Blans MC, Ammerdorffer A et al. Specific in vitro interferon-gamma and IL-2 production as biomarkers during treatment of chronic Q fever. Front Microbiol 2015; 6: 93
• 4 Schoffelen T, Sprong T, Bleeker-Rovers CP et al. A combination of interferon-gamma and interleukin-2 production by Coxiella burnetii-stimulated circulating cells discriminates between chronic Q fever and past Q fever. Clin Microbiol Infect 2014; 20: 642-650
• 5 Kampschreur LM, Hoornenborg E, Renders NHM et al. Delayed diagnosis of chronic Q fever and cardiac valve surgery. Emerg Infect Dis 2013; 19: 768-770
• 6 Wegdam-Blans MCA, Stokmans RA, Tjhie JHT et al. Targeted screening as a tool for the early detection of chronic Q fever patients after a large outbreak. Eur J Clin Microbiol Infect Dis 2013; 32: 353-359
• 7 Hagenaars JCJP, Wever PC, van Petersen AS et al. Estimated prevalence of chronic Q fever among Coxiella burnetii seropositive patients with an abdominal aortic / iliac aneurysm or aorto-iliac reconstruction after a large Dutch Q fever outbreak. J Infect 2014; 69: 154-160
• 8 Hagenaars JCJP, Renders NHM, van Petersen AS et al. Serological follow-up in patients with aorto-iliac disease and evidence of Q fever infection. Eur J Clin Microbiol Infect Dis 2014; 33: 1407-1414
• 9 Million M, Walter G, Thuny F et al. Evolution from acute Q fever to endocarditis is associated with underlying valvulopathy and age and can be prevented by prolonged antibiotic treatment. Clin Infect Dis 2013; 57: 836-844
• 10 Wielders CCH, Morroy G, Wever PC et al. Strategies for early detection of chronic Q-fever: a systematic review. Eur J Clin Invest 2013; 43: 616-639
• 11 Schoffelen T, Ammerdorffer A, Hagenaars JCJP et al. Genetic variation in pattern recognition receptors and adaptor proteins associated with development of chronic Q fever. J Infect Dis 2015; pii: jiv113
• 12 Hartzell JD. Q Fever reporting: tip of the iceberg?. Am J Trop Med Hyg 2015; 92: 217-218
• 13 Ayres JG, Flint N, Smith EG et al. Post-infection fatigue syndrome following Q fever. QJM 1998; 91: 105-123
• 14 Morroy G, Bor HHJ, Polder J et al. Self-reported sick leave and long-term health symptoms of Q-fever patients. Eur J Public Health 2012; 22: 814-819
• 15 Van Loenhout JAF, Hautvast JLA, Vercoulen JH et al. Q-fever patients suffer from impaired health status long after the acute phase of the illness: results from a 24-month cohort study. J Infect 2015; 70: 237-246
• 16 Keijmel SP, Delsing CE, Sprong T et al. The Qure study: Q fever fatigue syndrome – response to treatment; a randomized placebo-controlled trial. BMC Infect Dis 2013; 13: 157
• 17 Van Loenhout JAF, Paget WJ, Sandker GW et al. Assessing health status and quality of life of Q-fever patients: the Nijmegen Clinical Screening Instrument versus the Short Form 36. Health Qual Life Outcomes 2013; 11: 112