Leptin – ein Hormon mit vielen Facetten

Zusammenfassung

Leptin spielt eine zentrale Rolle in der neuroendokrinen Regulation der Energiehomöostase. Auch wenn der Stellenwert im Rahmen der Betreuung von adipösen Patienten in der Diagnostik und Therapie noch nicht völlig klar ist, hat der Einsatz von Leptin bei der Behandlung von einzelnen monogenen Adipositas-Formen aber entscheidende Fortschritte gebracht. Neben der Regulation des Energiestoffwechsels lassen die aktuellen Daten eine funktionelle Bedeutung von Leptin auch im Rahmen von intestinaler Nährstoffaufnahme, Blutdruckregulation, Fertilität, Inflammation und Autoimmunität vermuten. Daraus könnten sich in Zukunft weitere klinische und therapeutische Bedeutungen von Leptin ergeben.

Abstract

The role of leptin in regulation of energy homeostasis is well established, yet both the diagnostic as well as the therapeutic relevance of leptin in diet-induced obesity remains unresolved. Nevertheless, in the last few years, the substantial impact of leptin substitution in selected forms of monogenic obesity has advanced our knowledge about the neuroendocrine network of body weight regulation. Moreover, leptin seems to play a crucial role in intestinal nutrient reabsorption, regulation of blood pressure, fertility, inflammation and autoimmune diseases. A better understanding of these processes could possibly provide novel diagnostic and therapeutic options in the future.

Schlüsselwörter

Leptin - Energiehomöostase - Inflammation - Autoimmunität - Blutdruck

Keywords

Leptin - energy homeostasis - inflammation - autoimmune diseases - blood pressure

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