Subscribe to RSS
DOI: 10.1055/s-0041-109207
Laboruntersuchungen – was ist sinnvoll, was ist überflüssig?
Fast diagnostics in the emergency department: Laboratory testing – what we need and what we don’tPublication History
Publication Date:
03 March 2016 (online)
Zusammenfassung
Laborparameter in der Notfallmedizin lassen sich drei Kategorien einteilen. An erster Stelle stehen die obligatorischen Parameter, die unmittelbare therapeutische Konsequenzen nach sich ziehen und innerhalb von 60 Minuten vorgehalten werden sollten. Für diese Parameter bietet sich die Bestimmung vor Ort als „Point-of-Care“-Testverfahren (POCT) an. An zweiter Stelle stehen die obligatorischen Parameter, die zwar nicht akut zur Abwendung einer Lebensgefahr notwendig sind, jedoch mittelbare diagnostische bzw. therapeutische Konsequenzen haben. Nach dem internationalen Konsens sollte die Aufenthaltsdauer von Patienten in der Notaufnahme 4 Stunden nicht überschreiten. Deshalb müssen entsprechende Parameter innerhalb dieses Zeitfensters verfügbar sein. Daneben gibt es Parameter, die keine dringenden diagnostischen bzw. therapeutischen Konsequenzen nach sich ziehen, die jedoch als Notfallparameter verfügbar sein sollten, um die Prozesse in der Notaufnahme und den Patientenfluss aufrechtzuerhalten. POC-Testverfahren sollten wenigen dringlichen Parametern vorbehalten sein und in Kooperation mit dem Zentrallabor als Satellitenlabor in der Notaufnahme organisiert werden.
Abstract
Laboratory parameters in emergency medicine can be divided into 3 categories. Urgent obligatory parameters are necessary for immediate therapeutic decisions and must be available within 60 minutes. For these, testing in the emergency department (ED) as point-of-care-testing (POCT) should be considered. The second category are obligatory parameters which require diagnostic / therapeutic consequences in the emergency department, but are not necessary for immediate life-saving actions. Due to international consensus of a 4-hour length of stay target for ED, results should be available within this time. The third category are parameters which do not lead to immediate diagnostic or therapeutic consequences, but are important for process management and patient flow in the ED. They should therefore be available as emergency tests. POC-testing should be used for a limited number of very urgent parameters and should be organized as a satellite laboratory in cooperation with the central laboratory.
-
Literatur
- 1 Möckel M, Searle J, Huttner I et al. Qualitative process analysis and modelling of emergency care workflow and interface management: identification of critical process steps. Eur J Emerg Med 2015; 22: 79-86
- 2 Zorbalar N, Yesilaras M, Aksay E. Carbon monoxide poisoning in patients presenting to the emergency department with a headache in winter months. Emerg Med J 2014; 31: e66-e70
- 3 Lindner G, Exadaktylos AK. [Disorders of serum sodium in emergency patients: salt in the soup of emergency medicine]. Anaesthesist 2013; 62: 296-303
- 4 Schmidt BM. [The most frequent electrolyte disorders in the emergency department : what must be done immediately?]. Internist 2015; 56: 753-759
- 5 Marti G, Schwarz C, Leichtle AB et al. Etiology and symptoms of severe hypokalemia in emergency department patients. Eur J Emerg Med 2014; 21: 46-51
- 6 Thygesen K, Alpert JS, Jaffe AS et al. Third universal definition of myocardial infarction. Eur Heart J 2012; 33: 2551-2567
- 7 Roffi M, Patrono C, Collet JP et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J 2015; DOI: 10.1093/eurheartj/ehv320.
- 8 Möckel M, Searle J, Hamm C et al. Early discharge using single cardiac troponin and copeptin testing in patients with suspected acute coronary syndrome (ACS): a randomized, controlled clinical process study. Eur Heart J 2015; 36: 369-376
- 9 Selmer C, Olesen JB, Hansen ML et al. The spectrum of thyroid disease and risk of new onset atrial fibrillation: a large population cohort study. BMJ 2012; 345: e7895
- 10 Schütz P, Kutz A, Grolimund E et al. Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: results from the randomized ProHOSP trial. Int J Cardiol 2014; 175: 464-472
- 11 Maisel A, Neath SX, Landsberg J et al. Use of procalcitonin for the diagnosis of pneumonia in patients presenting with a chief complaint of dyspnoea: results from the BACH (Biomarkers in Acute Heart Failure) trial. Eur J Heart Fail 2012; 14: 278-286
- 12 Christ-Crain M, Jaccard-Stolz D, Bingisser R et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial. Lancet 2004; 363: 600-607
- 13 Simon L, Gauvin F, Amre DK et al. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis 2004; 39: 206-217
- 14 Wacker C, Prkno A, Brunkhorst FM et al. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis 2013; 13: 426-435
- 15 Casserly B, Phillips GS, Schorr C et al. Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med 2015; 43: 567-573
- 16 Bundesärztekammer. Querschnitts-Leitlinien (BÄK) zur Therapie mit Blutkomponenten und Plasmaderivaten, 4. überarbeitete und aktualisierte Auflage 2014 http://www.bundesaerztekammer.de/fileadmin/user_upload/downloads/QLL_Haemotherapie_2014.pdf Letzter Zugriff: 25.11.2015
- 17 Van Schaik SM, Scott S, de Lau LM et al. Short door-to-needle times in acute ischemic stroke and prospective identification of its delaying factors. Cerebrovasc Dis Extra 2015; 5: 75-83
- 18 Pollack Jr CV. Coagulation assessment with the new generation of oral anticoagulants. Emerg Med J 2015; DOI: 10.1136/emermed-2015–204891.
- 19 Newbatt E, Beckles Z, Ullman R et al. Ectopic pregnancy and miscarriage: summary of NICE guidance. BMJ 2012; 345: e8136
- 20 Mohammed AA, van Kimmenade RR, Richards M et al. Hyponatremia, natriuretic peptides, and outcomes in acutely decompensated heart failure: results from the International Collaborative of NT-proBNP Study. Circ Heart Fail 2010; 3: 354-361
- 21 Dettmer M, Holthaus CV, Fuller BM. The impact of serial lactate monitoring on emergency department resuscitation interventions and clinical outcomes in severe sepsis and septic shock: an observational cohort study. Shock 2015; 43: 55-61
- 22 Lazarenko GC, Dobson C, Enokson R et al. Accuracy and speed of urine pregnancy tests done in the emergency department: a prospective study. CJEM 2001; 3: 292-295
- 23 European Stroke Organisation (ESO). Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 2008; 25: 457-507
- 24 NHS England. A&E attendances and emergency admissions: June 2015 Monthly Report. https://www.england.nhs.uk/statistics/statistical-work-areas/ae-waiting-times-and-activity/statistical-work-areasae-waiting-times-and-activityae-attendances-and-emergency-admissions-2015-16-monthly-3/ Letzter Zugriff: 25.11.2015
- 25 McMurray JJ, Adamopoulos S, Anker SD et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2012; 14: 803-869
- 26 Konstantinides SV. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J 2014; 35: 3145-3146
- 27 Gemeinsame Erklärung der Deutschen AIDS-Gesellschaft (DAIG) und der Österreichischen AIDS-Gesellschaft (ÄAG). [Post-exposure prophylaxis of HIV infection. German-Austrian recommendations, update September 2007]. Dtsch Med Wochenschr 2009; 134 (Suppl. 1)
- 28 Spahn DR, Bouillon B, Cerny V et al. Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care 2013; 17: R76
- 29 Mägele M, Lefering R, Yucel N et al. Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury 2007; 38: 298-304
- 30 Mägele M, Inaba K, Rizoli S et al. [Early viscoelasticity-based coagulation therapy for severely injured bleeding patients : Report of the consensus group on the consensus conference 2014 for formulation of S2k guidelines]. Anaesthesist 2015; 64: 778-794
- 31 Hilbert-Carius P, Hofmann G, Stuttmann R. [Hemoglobin-oriented and coagulation factor-based algorithm : Effect on transfusion needs and standardized mortality rate in massively transfused trauma patients]. Anaesthesist 2015; 64: 828-838
- 32 Robert Koch Institut. Empfehlungen zur Prävention und Kontrolle von Methicillinresistenten Staphylococcus aureus-Stämmen (MRSA) in medizinischen und pflegerischen Einrichtungen Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) beim Robert Koch-Institut. Bundesgesundheitsblatt 2014; 57: 696-732
- 33 Robert Koch Institut. Influenza. 2015 http://www.rki.de/DE/Content/InfAZ/I/Influenza/IPV/IPV_Node.html letzter Zugriff: 4.12.2015
- 34 Heyerdahl F, Hovda KE, Giraudon I et al. Current European data collection on emergency department presentations with acute recreational drug toxicity: gaps and national variations. Clin Toxicol 2014; 52: 1005-1012
- 35 Fabbri A, Marchesini G, Morselli-Labate AM et al. Comprehensive drug screening in decision making of patients attending the emergency department for suspected drug overdose. Emerg Med J 2003; 20: 25-28
- 36 Pemmerl S. [Initial diagnosis and treatment for poisoning]. Med Klin Intensivmed Notfmed 2013; 108: 459-464
- 37 Wu AH, McKay C, Broussard LA et al. National academy of clinical biochemistry laboratory medicine practice guidelines: recommendations for the use of laboratory tests to support poisoned patients who present to the emergency department. Clin Chem 2003; 49: 357-379
- 38 Möckel M, Searle J. [Point-of-care testing in preclinical emergency medicine]. Med Klin Intensivmed Notfmed 2014; 109: 100-103
- 39 Post F, Gori T, Giannitsis E et al. Criteria of the German Society of Cardiology for the establishment of chest pain units: update 2014. Clin Res Cardiol 2015; 104: 918-928
- 40 Post F, Giannitsis E, Darius H et al. Kriterien der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung für „Chest Pain Units“, Update 2015. Kardiologe 2015; 9: 171-181