The Association between Serum Sodium Levels and Febrile Seizures Recurrence: Is the Degree of Hyponatremia a Risk Factor?

Abstract

Febrile seizures are common disorders in childhood. We evaluated the serum electrolyte levels and the associated factors in children with single and recurrent febrile seizures in 24 hours period of hospitalization. The medical records of children who were clinically diagnosed with febrile seizures and hospitalized were retrospectively revealed and analyzed. Data were collected for children aged 1 to 6 years including demographic parameters and serum electrolyte levels. A total of 244 children were enrolled in the study in which 209 were diagnosed with single febrile seizures and 35 of them with recurrent febrile seizures. Serum sodium levels were significantly lower in children with recurrent febrile seizure (138.5 ± 2.38 and 134.2 ± 3.55, p < 0.001). Correlation analysis revealed that mild hyponatremia is associated with recurrence of febrile seizure within 24 hours. However, receiver-operating characteristics analysis for hyponatremia showed lower sensitivity (50.3%) and specificity (43.1%) values for optimal cutoff value of 133.5 mmol/L of serum sodium level. Our study suggested that serum sodium levels were significantly lower in children with recurrent febrile seizures. However, because of its lower sensitivity and specificity values, mild hyponatremia cannot be used as an indicator for febrile seizure recurrence.

Keywords

febrile seizure - recurrence - serum sodium levels - risk factor - children

Authors' Contributions

E.K.A. and A.M.E. designed the study and wrote the manuscript. A.M.E. collected and analyzed the data. All authors read and approved the final manuscript.

Ethical Approval

This is a retrospective study. The authors assert that all procedures contributing to this study comply with the ethical standards of the Turkish Council of Medical Research and with the Helsinki Declaration of 1975, as revised in 2008, and has been approved by the local institutional committee of Dr. Ali Kemal Belviranlı Obstetrics and Children Hospital.

Publikationsverlauf

Eingereicht: 14. Oktober 2020

Angenommen: 03. Dezember 2020

Artikel online veröffentlicht:
11. Februar 2021

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