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Semin Liver Dis 2021; 41(03): 277-284
DOI: 10.1055/s-0041-1723030
Review Article

Assessing Toxicity in Drug Trials in Liver Disease

Morris Sherman
1   Research Administration, University Health Network, Toronto, Canada
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Abstract

Since the early trials in viral hepatitis, more and more new drugs are being tested for use in various liver diseases. Since drug hepatotoxicity is a major cause of drugs under investigation not making it to market, the assessment of drug-induced liver injury in clinical trials of new drugs is crucial. This review will focus on the systems that are used to assess drug-induced liver injury in clinical trials and will discuss how some of these criteria are inappropriate or inaccurate in this function together with suggestions for improvement.

Keywords

clinical trials - drug-induced liver injury - adverse event


Publikationsverlauf

Artikel online veröffentlicht:
08. März 2021

© 2021. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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