Subscribe to RSS
DOI: 10.1055/s-0041-1723036
Respiratory Care in Children with COVID-19
Abstract
The novel coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is causing significant morbidity and mortality worldwide. The common presentations in children include involvement of respiratory system leading to pneumonia and acute respiratory distress syndrome, as well as multiorgan dysfunction syndrome and multisystem inflammatory syndrome in children (MIS-C). Pediatric COVID-19 is a milder disease as compared with the adults. Also, there is rise in MIS-C cases which is a hyperinflammatory condition temporally associated with SARS-CoV-2. Since respiratory system is predominantly involved, few of these critically ill children often require respiratory support which can range from simple oxygen delivery devices, high-flow nasal cannula (HFNC), noninvasive ventilation (NIV), invasive mechanical ventilation, and extracorporeal membrane oxygenation (ECMO). Most of the oxygen delivery devices and respiratory interventions generate aerosols and pose risk of transmission of virus to health care providers (HCPs). The use of HFNC and NIV should be limited to children with mild respiratory distress preferably in negative pressure rooms and with adequate personal protective equipment (PPE). However, there should be low thresholds for intubation and invasive mechanical ventilation in the event of clinical deterioration while on any respiratory support. The principle of providing respiratory support requires special droplet and air-borne precautions to limit exposure or transmission of virus to HCPs and at the same time ensuring safety of the patient.
Keywords
COVID-19 - noninvasive ventilation - high-flow nasal cannula - personal protective equipment - mechanical ventilationAuthors' Contributions
S.G. and S.K.A. reviewed the literature and prepared the initial draft. V.K. critically evaluated and modified the manuscript. S.G. will act as guarantor of the paper.
Publication History
Received: 15 October 2020
Accepted: 20 December 2020
Article published online:
11 February 2021
© 2021. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
References
- 1 Mehta Y, Chaudhry D, Abraham OC. et al. Critical care for COVID-19 affected patients: position statement of the Indian Society of Critical Care Medicine. Indian J Crit Care Med 2020; 24 (04) 222-241
- 2 Phua J, Weng L, Ling L. et al; Asian Critical Care Clinical Trials Group. Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations. Lancet Respir Med 2020; 8 (05) 506-517
- 3 WHO–China Joint Mission. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). March 7, 2020 at: https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf.Accessed
- 4 Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr 2020; 109 (06) 1088-1095
- 5 Lu X, Zhang L, Du H. et al; Chinese Pediatric Novel Coronavirus Study Team. SARS-CoV-2 infection in children. N Engl J Med 2020; 382 (17) 1663-1665
- 6 Dong Y, Mo X, Hu Y. et al. Epidemiology of COVID -19 among children in China. Pediatrics 2020; 145 (06) e20200702
- 7 Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics. J Formos Med Assoc 2020; 119 (03) 670-673
- 8 Ong JSM, Tosoni A, Kim Y, Kissoon N, Murthy S. Coronavirus disease 2019 in critically ill children: a narrative review of the literature. Pediatr Crit Care Med 2020; 21 (07) 662-666
- 9 Parri N, Lenge M, Buonsenso D. Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) Research Group. Children with COVID-19 in pediatric emergency departments in Italy. N Engl J Med 2020; 383 (02) 187-190
- 10 CDC COVID-19 Response Team. Corona virus disease 2019 in children — United States, February 12–April 2, 2020. MMWR 2020; 69 (14) 422-426
- 11 Tagarro A, Epalza C, Santos M. et al. Screening and severity of coronavirus disease 2019 (COVID-19) in children in Madrid, Spain. JAMA Pediatr 2021; 175 (03) 316-317
- 12 Castagnoli R, Votto M, Licari A. et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review. JAMA Pediatr 2020; 174 (09) 882-889
- 13 Chen F, Liu ZS, Zhang FR. et al. [First case of severe childhood novel coronavirus pneumonia in China] (in Chinese). Zhonghua Er Ke Za Zhi 2020; 58 (03) 179-182
- 14 Stanton BA, Hampton TH, Ashare A. The pathophysiology of COVID-19 and SARS-CoV-2 infection. Am J Physiol Lung Cell Mol Physiol 2020; 319 (03) L408-L415
- 15 Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 2020; 395 (10237): 1607-1608
- 16 Feldstein LR, Rose EB, Horwitz SM. et al; Overcoming COVID-19 Investigators, CDC COVID-19 Response Team. Multisystem inflammatory syndrome in U.S. children and adolescents. N Engl J Med 2020; 383 (04) 334-346
- 17 Belot A, Antona D, Renolleau S. et al. SARS-CoV-2-related paediatric inflammatory multisystem syndrome, an epidemiological study, France, 1 March to 17 May 2020. Euro Surveill 2020; 25 (22) 2001010
- 18 Dufort EM, Koumans EH, Chow EJ. et al; New York State and Centers for Disease Control and Prevention Multisystem Inflammatory Syndrome in Children Investigation Team. Multisystem inflammatory syndrome in children in New York State. N Engl J Med 2020; 383 (04) 347-358
- 19 Davies P, Evans C, Kanthimathinathan HK. et al. Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study. Lancet Child Adolesc Health 2020; 4 (09) 669-677
- 20 Kaushik A, Gupta S, Sood M, Sharma S, Verma S. A systematic review of multisystem inflammatory syndrome in children associated with SARS-CoV-2 infection. Pediatr Infect Dis J 2020; 39 (11) e340-e346
- 21 Aronoff SC, Hall A, Del Vecchio MT. The natural history of SARS-Cov-2 related multisystem inflammatory syndrome in children (MIS-C): a systematic review. J Pediatric Infect Dis Soc 2020; 112: 1-6
- 22 Ahmed M, Advani S, Moreira A. et al. Multisystem inflammatory syndrome in children: A systematic review. EClinicalMedicine 2020; 26: 100527
- 23 Jain S, Sen S, Lakshmivenkateshiah S. et al. Multisystem inflammatory syndrome in children with COVID-19 in Mumbai, India. Indian Pediatr 2020; 57 (11) 1015-1019
- 24 Dhanalakshmi K, Venkataraman A, Balasubramanian S. et al. Epidemiological and clinical profile of pediatric inflammatory multisystem syndrome - temporally associated with SARS-CoV-2 (PIMS-TS) in Indian children. Indian Pediatr 2020; 57 (11) 1010-1014
- 25 Williams V, Dash N, Suthar R. et al. Clinico-laboratory profile, intensive care needs, treatment details, and outcome of Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): A systematic review and Meta-analysis. medRxiv 2020; DOI: 10.1101/2020.10.21.20217034.
- 26 Duan YN, Zhu YQ, Tang LL, Qin J. CT features of novel coronavirus pneumonia (COVID-19) in children. Eur Radiol 2020; 30 (08) 4427-4433
- 27 Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID-19 infection: different points from adults. Pediatr Pulmonol 2020; 55 (05) 1169-1174
- 28 Merkus PJFM, Klein WM. The value of chest CT as a COVID-19 screening tool in children. Eur Respir J 2020; 55 (06) 200124
- 29 Kulkarni S, Down B, Jha S. Point-of-care lung ultrasound in intensive care during the COVID-19 pandemic. Clin Radiol 2020; 75 (09) 710.e1-710.e4
- 30 Soldati G, Smargiassi A, Inchingolo R. et al. Is there a role for lung ultrasound during the COVID-19 pandemic?. J Ultrasound Med 2020; 39 (07) 1459-1462
- 31 Mohamed MFH, Al-Shokri S, Yousaf Z. et al. Frequency of abnormalities detected by point-of-care lung ultrasound in symptomatic COVID-19 patients: Systematic review and meta-analysis. Am J Trop Med Hyg 2020; 103 (02) 815-821
- 32 Gu H, Xie Z, Li T. et al. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Sci Rep 2016; 6: 19840
- 33 Jiehao C, Jin X, Daojiong L. et al. A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis 2020; 71 (06) 1547-1551
- 34 Widders A, Broom A, Broom J. SARS-CoV-2: the viral shedding vs infectivity dilemma. Infect Dis Health 2020; 25 (03) 210-215
- 35 Xu CLH, Raval M, Schnall JA, Kwong JC, Holmes NE. Duration of respiratory and gastrointestinal viral shedding in children with SARS-CoV-2: a systematic review and synthesis of data. Pediatr Infect Dis J 2020; 39 (09) e249-e256
- 36 Santos VS, Gurgel RQ, Cuevas LE, Martins-Filho PR. Prolonged fecal shedding of SARS-CoV- 2 in pediatric patients: a quantitative evidence synthesis. J Pediatr Gastroenterol Nutr 2020; 71 (02) 150-152
- 37 Posfay-Barbe KM, Wagner N, Gauthey M. et al. COVID-19 in children and the dynamics of infection in families. Pediatrics 2020; 146 (02) e20201576
- 38 Edelson DP, Sasson C, Chan PS. et al; American Heart Association ECC Interim COVID Guidance Authors. Interim guidance for basic and advanced life support in adults, children, and neonates with suspected or confirmed COVID-19: from the emergency cardiovascular care committee and get with the guidelines-resuscitation adult and pediatric Task Forces of the American Heart Association. Circulation 2020; 141 (25) e933-e943
- 39 Alhazzani W, Møller MH, Arabi YM. et al. Surviving sepsis campaign: guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19). Intensive Care Med 2020; 46 (05) 854-887
- 40 Kache S, Chisti MJ, Gumbo F. et al. COVID-19 PICU guidelines: for high- and limited-resource settings. Pediatr Res 2020; 88 (05) 705-716
- 41 Sundaram M, Ravikumar N, Bansal A. et al; Intensive Care Chapter of Indian Academy of Pediatrics. Novel coronavirus 2019 (2019-nCoV) infection: part II - respiratory support in the pediatric intensive care unit in resource-limited settings. Indian Pediatr 2020; 57 (04) 335-342
- 42 Tran K, Cimon K, Severn M, Pessoa-Silva CL, Conly J. Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review. PLoS One 2012; 7 (04) e35797
- 43 Simonds AK, Hanak A, Chatwin M. et al. Evaluation of droplet dispersion during non-invasive ventilation, oxygen therapy, nebuliser treatment and chest physiotherapy in clinical practice: implications for management of pandemic influenza and other airborne infections. Health Technol Assess 2010; 14 (46) 131-172
- 44 Castro-Codesal ML, Olmstead DL, MacLean JE. Mask interfaces for home non-invasive ventilation in infants and children. Paediatr Respir Rev 2019; 32: 66-72
- 45 Ramirez A, Khirani S, Aloui S. et al. Continuous positive airway pressure and noninvasive ventilation adherence in children. Sleep Med 2013; 14 (12) 1290-1294
- 46 Hui DS, Chow BK, Lo T. et al. Exhaled air dispersion during high-flow nasal cannula therapy versus CPAP via different masks. Eur Respir J 2019; 53 (04) 1802339
- 47 Leung CCH, Joynt GM, Gomersall CD. et al. Comparison of high-flow nasal cannula versus oxygen face mask for environmental bacterial contamination in critically ill pneumonia patients: a randomized controlled crossover trial. J Hosp Infect 2019; 101 (01) 84-87
- 48 Raboud J, Shigayeva A, McGeer A. et al. Risk factors for SARS transmission from patients requiring intubation: a multicentre investigation in Toronto, Canada. PLoS One 2010; 5 (05) e10717
- 49 Rochwerg B, Granton D, Wang DX. et al. High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis. Intensive Care Med 2019; 45 (05) 563-572
- 50 Agarwal A, Basmaji J, Muttalib F. et al. High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission. Can J Anaesth 2020; 67 (09) 1217-1248
- 51 Frat JP, Thille AW, Mercat A. et al; FLORALI Study Group, REVA Network. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 2015; 372 (23) 2185-2196
- 52 Alraddadi BM, Qushmaq I, Al-Hameed FM. et al; Saudi Critical Care Trials Group. Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome. Influenza Other Respir Viruses 2019; 13 (04) 382-390
- 53 Brochard L, Lefebvre JC, Cordioli RL, Akoumianaki E, Richard JC. Noninvasive ventilation for patients with hypoxemic acute respiratory failure. Semin Respir Crit Care Med 2014; 35 (04) 492-500
- 54 Wax RS, Christian MD. Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients. Can J Anaesth 2020; 67 (05) 568-576
- 55 Rimensberger PC, Cheifetz IM. Pediatric Acute Lung Injury Consensus Conference Group. Ventilatory support in children with pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med 2015; 16 (05, Suppl 1): S51-S60
- 56 Alhazzani W, Alshahrani M, Jaeschke R. et al. Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials. Crit Care 2013; 17 (02) R43
- 57 Munshi L, Del Sorbo L, Adhikari NKJ. et al. Prone position for acute respiratory distress syndrome. a systematic review and meta-analysis. Ann Am Thorac Soc 2017; 14 (Suppl. 04) S280-S288
- 58 Tiwari L, Taneja LN, Gupta S. and Other Expert Committee Members. IAP ALS update on resuscitation guidelines during COVID-19 pandemic. Indian J Pediatr 2020; 27: 1-7