Endoscopic Submucosal Dissection and barrett’s ESOPHAGUS - Results of the German ESD Registry

Aims In Europe, endoscopic submucosal dissection (ESD) is not yet the standard treatment for premalignant or early malignant lesions in the gastrointestinal (GI)-tract. High quality data is limited to single center studies. The German ESD registry was set up to evaluate and assess the technical success, curative resection rate, economic aspects as well as long term outcomes of ESD procedures performed in Germany. In this study, we present results of ESD procedures in Barrett’s esophagus (BE) from the German ESD registry.

Methods The German ESD registry study is a prospective, multicenter trial. Management and evaluation of collected data is done in a central data base at Universitätsklinikum Augsburg, Germany. Data is collected anonymously via electronic case report form (eCRF), and is still ongoing.

Results From the 1^st of January 2017 to 1^st January 2020, 20 hospitals included 300 ESDs in Barrett’s esophagus. In 287 cases (95.7 %) a standard ESD was performed, and in 13 cases a hybrid ESD (4.3 %). Histopathological assessment showed 268 adenocarcinomas, 20 cases with high-grade dysplasia and 12 cases with low-grade dysplasia.

An overall en-bloc resection rate of 96 % (288/300) was achieved. The R0 resection rate was 75 % (226/300), a curative resection rate of 70 % (210/300) was achieved. Complications occurred in 10 out of 300 cases (3.3 %). Delayed bleeding was reported in 6 cases, blood transfusion was necessary in 1 case. Four perforations were documented (3x intraprocedural, 1x delayed).

Conclusions A total of 300 ESD procedures in Barrett’s esophagus were registered so far with excellent en-bloc resection rate and low complication rates. With regards to R0-and curative resection rates, there is some room for improvement. Further data collection and data analysis will help to expand on the results shown here.

Citation: Fleischmann C, Probst A, Ebigbo A et al. OP26 ENDOSCOPIC SUBMUCOSAL DISSECTION AND BARRETT’S ESOPHAGUS - RESULTS OF THE GERMAN ESD REGISTRY. Endoscopy 2021; 53: S14.

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Artikel online veröffentlicht:
19. März 2021