Endoscopy 2021; 53(S 01): S95-S96
DOI: 10.1055/s-0041-1724499
Abstracts | ESGE Days
ESGE Days 2021 Oral presentations
Saturday, 27 March 2021 17:00 – 17:45 Colonoscopy for screening or surveillance Room 6

Risk Factors Related To Advanced Colorectal Neoplasia In Colorectal Cancer Screening – Interim Results Of Multicentric Prospective Study

T Grega
1   Department of Internal Medicine, Faculty of Medicine, Charles University, Military University Hospital, Prague, Czech Republic
,
G Vojtechova
1   Department of Internal Medicine, Faculty of Medicine, Charles University, Military University Hospital, Prague, Czech Republic
,
O Ngo
2   Faculty of Medicine, Masaryk University, Institute of Biostatistics and Analyses, Brno, Czech Republic
3   Institute of Health Information and Statistics, Prague, Czech Republic
,
Ambrozova,
O Majek
2   Faculty of Medicine, Masaryk University, Institute of Biostatistics and Analyses, Brno, Czech Republic
3   Institute of Health Information and Statistics, Prague, Czech Republic
,
M Zavoral
1   Department of Internal Medicine, Faculty of Medicine, Charles University, Military University Hospital, Prague, Czech Republic
,
S Suchanek
1   Department of Internal Medicine, Faculty of Medicine, Charles University, Military University Hospital, Prague, Czech Republic
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Aims The lifetime risk of developing colorectal cancer in average risk population is 4.4 %. The prevalence of advanced colorectal neoplasia in the screening population shows great diversity around 3-12 % depending on multiple risk factors. The aim of the study was to determine the risk factors associated with the incidence of advanced colorectal neoplasia in the screening population.

Methods The prospective multicentric study included asymptomatic individuals aged 45-75 years who underwent preventive colonoscopy in 2012–2015. Data were collected and analyzed using descriptive statistics. The Fisher’s exact test was used to compare the risk factors with the occurrence of advanced colorectal neoplasia.

Results 1,108 men (56.3 %) and 859 women (43.7 %) were included (average age 60 years). The total number of advanced colorectal neoplasia was 11.8 % (233 individuals). The potential risk factors associated with advanced colorectal neoplasia were age (p < 0.001), male gender (p = 0.001), smoking (p < 0.001), serum concentrations of triglycerides (p = 0.029; especially concentrations > 2 mmol/l) and low vitamin D (p = 0.033). These are preliminary results which will be specified in the following more detailed data analysis using logistic regression.

Conclusions The strongest potential risk factors associated with advanced colorectal neoplasia were age, gender and smoking. In addition to these factors, serum triglyceride levels and low vitamin D were significantly associated with advanced colorectal neoplasia. To individuals with these risk factors should be addressed increased attention and considered primary screening colonoscopy.

The study was supported by the Czech Ministry of Health grants No. 17-31909A and No. NV18-08-00246 and projects MO1012 and Progres Q28/LF1.

Citation: Grega T, Vojtechova G, Ngo O et al. OP235 RISK FACTORS RELATED TO ADVANCED COLORECTAL NEOPLASIA IN COLORECTAL CANCER SCREENING – INTERIM RESULTS OF MULTICENTRIC PROSPECTIVE STUDY. Endoscopy 2021; 53: S95.



Publication History

Article published online:
19 March 2021

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