Subscribe to RSS
DOI: 10.1055/s-0041-1725051
Cervical Mesonephric Adenocarcinoma: A Case Report of a Rare Gynecological Tumor from Embryological Remains of the Female Genital Tract
Adenocarcinoma mesonéfrico cervical: Relato de caso de um tumor ginecológico raro de restos embriológicos do trato genital femininoAbstract
Introduction Malignant mesonephric tumors are uncommon in the female genital tract, and they are usually located where embryonic remnants of Wolffian ducts are detected, such as the uterine cervix. The information about these tumors, their treatment protocol, and prognosis are scarce.
Case report A 60-year-old woman with postmenopausal vaginal bleeding was initially diagnosed with endometrial carcinoma. After suspicion co-testing, the patient underwent a loop electrosurgical excision of the cervix and was eventually diagnosed with mesonephric adenocarcinoma. She was subjected to a radical hysterectomy, which revealed International Federation of Gynecology and Obstetrics (FIGO) IB1 stage, and adjuvant radiotherapy. The follow-up showed no evidence of recurrence after 60 months.
Conclusion We present the case of a woman with cervical mesonephric adenocarcinoma. When compared with the literature, this case had the longest clinical follow-up without evidence of recurrence, which reinforces the concept that these tumors are associated with a favorable prognosis if managed according to the guidelines defined for the treatment of patients with cervical adenocarcinomas. Though a rare entity, it should be kept in mind as a differential diagnosis for other cervical cancers.
Publication History
Received: 29 April 2020
Accepted: 15 December 2020
Article published online:
30 March 2021
© 2021. Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil
-
References
- 1 Howitt BE, Nucci MR. Mesonephric proliferations of the female genital tract. Pathology 2018; 50 (02) 141-150
- 2 Ferry JA, Scully RE. Mesonephric remnants, hyperplasia, and neoplasia in the uterine cervix. A study of 49 cases. Am J Surg Pathol 1990; 14 (12) 1100-1111
- 3 Wu H, Zhang L, Cao W, Hu Y, Liu Y. Mesonephric adenocarcinoma of the uterine corpus. Int J Clin Exp Pathol 2014; 7 (10) 7012-7019
- 4 Meguro S, Yasuda M, Shimizu M, Kurosaki A, Fujiwara K. Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. Diagn Pathol 2013; 8: 74
- 5 Park KJ, Kiyokawa T, Soslow RA, Lamb CA, Oliva E, Zivanovic O. et al. Unusual endocervical adenocarcinomas: an immunohistochemical analysis with molecular detection of human papillomavirus. Am J Surg Pathol 2011; 35 (05) 633-646
- 6 Bifulco G, Mandato VD, Mignogna C, Giampaolino P, Sardo AS, De Cecio R. et al. A case of mesonephric adenocarcinoma of the vagina with a 1-year follow-up. Int J Gynecol Cancer 2008; 18 (05) 1127-1131
- 7 Yap OWS, Hendrickson MR, Teng NNH, Kapp DS. Mesonephric adenocarcinoma of the cervix: a case report and review of the literature. Gynecol Oncol 2006; 103 (03) 1155-1158
- 8 Silver SA, Devouassoux-Shisheboran M, Mezzetti TP, Tavassoli FA. Mesonephric adenocarcinomas of the uterine cervix: a study of 11 cases with immunohistochemical findings. Am J Surg Pathol 2001; 25 (03) 379-387
- 9 Pirog EC, Kleter B, Olgac S, Bobkiewicz P, Lindeman J, Quint WG. et al. Prevalence of human papillomavirus DNA in different histological subtypes of cervical adenocarcinoma. Am J Pathol 2000; 157 (04) 1055-1062
- 10 Cavalcanti MS, Schultheis AM, Ho C, Wang L, DeLair DF, Weigelt B. et al. Mixed mesonephric adenocarcinoma and high-grade neuroendocrine carcinoma of the uterine cervix: case description of a previously unreported entity with insights into its molecular pathogenesis. Int J Gynecol Pathol 2017; 36 (01) 76-89
- 11 Dierickx A, Göker M, Braems G, Tummers P, Van den Broecke R. Mesonephric adenocarcinoma of the cervix: Case report and literature review. Gynecol Oncol Rep 2016; 17: 7-11
- 12 Montalvo N, Redrobán L, Galarza D. Mesonephric adenocarcinoma of the cervix: a case report with a three-year follow-up, lung metastases, and next-generation sequencing analysis. Diagn Pathol 2019; 14 (01) 71
- 13 Zhang L, Cai Z, Ambelil M, Conyers J, Zhu H. Mesonephric adenocarcinoma of the uterine corpus: report of 2 cases and review of the literature. Int J Gynecol Pathol 2019; 38 (03) 224-229
- 14 Mirkovic J, Dong F, Sholl LM, Garcia E, Lindeman N, MacConaill L. et al. Targeted Genomic Profiling of Female Adnexal Tumors of Probable Wolffian Origin (FATWO). Int J Gynecol Pathol 2019; 38 (06) 543-551
- 15 Yamamoto Y, Akagi A, Izumi K, Kishi Y. Carcinosarcoma of the uterine body of mesonephric origin. Pathol Int 1995; 45 (04) 303-309
- 16 Ribeiro B, Silva R, Dias R, Patrício V. Carcinosarcoma of the uterine cervix: a rare pathological finding originating from mesonephric remnants. BMJ Case Rep 2019; 12 (03) e227050
- 17 Chapel DB, Joseph NM, Krausz T, Lastra RR. An ovarian adenocarcinoma with combined low-grade serous and mesonephric morphologies suggests a müllerian origin for some mesonephric carcinomas. Int J Gynecol Pathol 2018; 37 (05) 448-459
- 18 Howitt BE, Emori MM, Drapkin R, Gaspar C, Barletta JA, Nucci MR. et al. GATA3 is a sensitive and specific marker of benign and malignant mesonephric lesions in the lower female genital tract. Am J Surg Pathol 2015; 39 (10) 1411-1419
- 19 Lee S, Rose MS, Sahasrabuddhe VV, Zhao R, Duggan MA. Tissue-based immunohistochemical biomarker accuracy in the diagnosis of malignant glandular lesions of the uterine cervix: a systematic review of the literature and meta-analysis. Int J Gynecol Pathol 2017; 36 (04) 310-322