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CC BY 4.0 · Journal of Child Science 2021; 11(01): e55-e59
DOI: 10.1055/s-0041-1725079
Research Article

Diagnostic Performance of Noninvasive Methods for Liver Biopsy by Fibroscan in Pediatric

Ghobad Heidari 
1   Department of Pediatric, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
,
Farzaneh Motamed‡   *
2   Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Bita Heirati
3   Department of Pediatric, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
,
Parisa Rahmani    *
2   Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
› Author Affiliations Funding None.
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Abstract

Liver biopsy is the gold standard for the diagnosis and management of various liver diseases; however, noninvasive diagnostic modalities may help prevent adverse effects of anesthesia, prolonged hospitalization, sampling error, and other serious complications, particularly in pediatric patients. The aim of this study is to compare the results of liver biopsy and fibroscan in children with chronic liver diseases. All patients presenting chronic liver disease admitted in the ward or clinic of Tehran's Children Medical Center were enrolled in the study. Required laboratory tests were performed to diagnose the disease, followed by elastography using fibroscan 402 (M-probe) Echosens machine and liver biopsy using Menghini technique. Samples were scored by using METAVIR scoring system. Thirty-two patients were reported (68.8%, female) with autoimmune hepatitis (18.8%), Wilson disease (12.5%), and glycogen storage disease (12.5%). The most common pathologic stage and fibroscan result was stage III and F0 (46.9%), respectively. Association between pathology and fibroscan results was not significant. Nonetheless, age and diagnosis, age and Fibroscan score, and pathology and liver function test were significantly associated with each other. Fibroscan cannot be used as an alternative to liver biopsy; however, it can be a useful accessory tool.

Keywords

fibroscan - liver biopsy - elastography - pediatric - Menghini technique - METAVIR scoring

* The authors contributed equally to this work.


Note

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.


Authors' Contributions

P.R. and G.H. conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. F.M. designed the data collection instruments, collected data, performed the initial analyses, and reviewed and revised the manuscript. B.H. coordinated and supervised data collection, and critically reviewed the manuscript for important intellectual content.




Publication History

Received: 08 September 2020

Accepted: 19 January 2021

Article published online:
25 February 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
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