Abstract
Objectives The aim of the present study is to evaluate the role of immunoglobulins (IgA, IgG,
and IgM) and circulating immune complexes (CIC) as tumor marker in oral cancer and
precancer patients.
Materials and Methods The present study was performed on 45 individuals subdivided into three groups, that
is, oral precancer, oral cancer and healthy individuals, and levels of immunoglobulins,
and CIC was estimated by turbidometry and ELISA method.
Results In the present study, the mean serum IgA levels in oral precancer were 161.00 ( ± 118.02)
mg/dL, oral cancers were 270.67 ( ± 171.44) mg/dL, and controls were 133.73 ( ± 101.31)
mg/dL. Mean serum levels of IgG in oral precancer were 1,430.87 ( ± 316) mg/dL, oral
cancers were 1,234.27 ( ± 365.42) mg/dL, and controls were 593.87 ( ± 323.06) mg/dL.
Conclusion We found that the levels of serum IgG and IgA were elevated consistently in precancer
and cancer group, and Serum IgM levels were increased only in precancer. Also, significant
increase in serum CIC levels were seen in oral precancer and cancer group on comparison
with control.
Keywords
serum immunoglobulin - circulating immune complex - oral precancer - oral cancer patients
- oral squamous cell carcinoma
