RSS-Feed abonnieren
PDF herunterladen
DOI: 10.1055/s-0041-1726152
Recent Advances in Trigeminal Neuralgia and Its Management: A Narrative Review
Abstract
Trigeminal neuralgia (TN) is a chronic facial pain condition that affects one or more divisions of the trigeminal nerve (5th cranial nerve). It can be idiopathic, primary, or secondary. The cornerstone of the therapy has been antiepileptic medications, peripheral nerve blocks with various neurolytic agents, and surgical procedures. With the advent of newer technologies, minimally invasive neurolytic techniques like low-level laser therapy and ozone injection have revolutionized the management of TN. Novel drugs like vixotrigine and eslicarbazepine have been promising in reducing the frequency and severity of attacks. Inhaled carbon dioxide too has shown promising results in initial trials. Neuromodulation has given robust data in controlling neuralgic pain especially refractory to medical management. Pulsed radiofrequency has been used with increasing success and the side effects like dysesthesia and paresthesia are less. Cryotherapy, neural prolotherapy, and fiber knife techniques have helped us believe that TN can be controlled and cured. The need of the hour is to develop and explore newer modalities for trigeminal neuralgia treatment with minimum side effects. In this narrative review, we have tried to shed light into the newer modalities of treatment of TN along with new clinical classification for better disease recognition and management.
Keywords
anticonvulsants - facial pain - neuromodulation - pulsed radiofrequency - trigeminal neuralgiaPublikationsverlauf
Artikel online veröffentlicht:
24. Mai 2021
© 2021. Indian Society of Neuroanaesthesiology and Critical Care. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Bangash TH. Trigeminal neuralgia: frequency of occurrence in different nerve branches. Anesth Pain Med 2011; 1 (02) 70-72
- 2 McMillan R. Trigeminal neuralgia—a debilitating facial pain. Rev Pain 2011; 5 (01) 26-34
- 3 Wu TH, Hu LY, Lu T. et al. Risk of psychiatric disorders following trigeminal neuralgia: a nationwide population-based retrospective cohort study. J Headache Pain 2015; 16: 64
- 4 Hall GC, Carroll D, Parry D, McQuay HJ. Epidemiology and treatment of neuropathic pain: the UK primary care perspective. Pain 2006; 122 (1-2) 156-162
- 5 Cruccu G, Finnerup NB, Jensen TS. et al. Trigeminal neuralgia: new classification and diagnostic grading for practice and research. Neurology 2016; 87 (02) 220-228
- 6 Bonica JL. The Management of Pain. 2nd ed. Malvern, PA: Lea and Febiger 1990: 180
- 7 Di G Stefano, Truini A, Cruccu G. Current and innovative pharmacological options to treat typical and atypical trigeminal neuralgia. Drugs 2018; 78 (14) 1433-1442
- 8 Chen DQ, DeSouza DD, Hayes DJ, Davis KD, O’Connor P, Hodaie M. Diffusivity signatures characterize trigeminal neuralgia associated with multiple sclerosis. MultScler 2016; 22 (01) 51-63
- 9 Jia DZ, Li G. Bioresonance hypothesis: a new mechanism on the pathogenesis of trigeminal neuralgia. Med Hypotheses 2010; 74 (03) 505-507
- 10 Devor M, Amir R, Rappaport ZH. Pathophysiology of trigeminal neuralgia: the ignition hypothesis. Clin J Pain 2002; 18 (01) 4-13
- 11 Han-Bing S, Wei-Guo Z, Jun Z. Ning L, Jian-Kang S, Yu C. Predicting the outcome of microvascular decompression for trigeminal neuralgia using magnetic resonance tomographic angiography. J Neuroimaging 2010; 20 (04) 345-349
- 12 Montano N, Conforti G, Di Bonaventura R, Meglio M, Fernandez E, Papacci F. Advances in diagnosis and treatment of trigeminal neuralgia. Ther Clin Risk Manag 2015; 11: 289-299
- 13 Hasan S. Trigeminal neuralgia: an overview of literature with emphasis on medical management. Int Res J Pharma. 2012; 3: 235-238
- 14 Mishra RK, Rath GP. Complimentary medicine in trigeminal neuralgia. In: Rath GP, ed. Handbook of Trigeminal Neuralgia. Singapore: Springer Nature 2019: 207-213
- 15 Perloff MD, Chung JS. Urgent care peripheral nerve blocks for refractory trigeminal neuralgia. Am J Emerg Med 2018; 36 (11) 2058-2060
- 16 Han KR, Chae YJ, Lee JD, Kim C. Trigeminal nerve block with alcohol for medically intractable classic trigeminal neuralgia: long-term clinical effectiveness on pain. Int J Med Sci 2017; 14 (01) 29-36
- 17 Zhang H, Lian Y, Ma Y. et al. Two doses of botulinum toxin type A for the treatment of trigeminal neuralgia: observation of therapeutic effect from a randomized, double-blind, placebo-controlled trial. J Headache Pain 2014; 15: 65
- 18 Fischoff DK, Spivakovsky S. Botulinum toxin for facial neuralgia. Evid Based Dent 2018; 19 (02) 57-58
- 19 Gu W, Zhao W. Microvascular decompression for recurrent trigeminal neuralgia. J Clin Neurosci 2014; 21 (09) 1549-1553
- 20 Abhinav K, Love S, Kalantzis G, Coakham HB, Patel NK. Clinicopathological review of patients with and without multiple sclerosis treated by partial sensory rhizotomy for medically refractory trigeminal neuralgia: a 12-year retrospective study. ClinNeurolNeurosurg 2012; 114 (04) 361-365
- 21 Zagzoog N, Attar A, Takroni R, Alotaibi MB, Reddy K. Endoscopic versus open microvascular decompression for trigeminal neuralgia: a systematic review and comparative meta-analysis. J Neurosurg 2018; 7: 1-9
- 22 Hesselink JMK. Moving targets in sodium channel blocker development: the case of raxatrigine: from a central NaV1.3 blocker via a peripheral NaV1.7 blocker to a less selective sodium channel blocker. J Med Therap 2017; 1: 1-3
- 23 Obermann M. Recent advances in understanding/managing trigeminal neuralgia. F1000 Res 2019; 8: F1000
- 24 Sanchez-Larsen A, Sopelana D, Diaz-Maroto I. et al. Assessment of efficacy and safety of eslicarbazepine acetate for the treatment of trigeminal neuralgia. Eur J Pain 2018; 22 (06) 1080-1087
- 25 Moore D, Chong MS, Shetty A, Zakrzewska JM. A systematic review of rescue analgesic strategies in acute exacerbations of primary trigeminal neuralgia. Br J Anaesth 2019; 123 (02) e385-e396
- 26 Kanai A, Suzuki A, Osawa S, Hoka S. Sumatriptan alleviates pain in patients with trigeminal neuralgia. Clin J Pain 2006; 22 (08) 677-680
- 27 Vause C, Bowen E, Spierings E, Durham P. Effect of carbon dioxide on calcitonin gene-related peptide secretion from trigeminal neurons. Headache 2007; 47 (10) 1385-1397
- 28 Jürgens TP, Reetz R, May A. No relevant modulation of TRPV1-mediated trigeminal pain by intranasal carbon dioxide in healthy humans. J Headache Pain 2013; 14: 33
- 29 ClinicalTrials.gov. Nasal carbon dioxide for the symptomatic treatment of classical trigeminal neuralgia. Available at: https://clinicaltrials.gov/ct2/show/record/NCT02473016. Published June 16, 2015. Accessed December 28, 2020
- 30 Patel R, Montagut-Bordas C, Dickenson AH. Calcium channel modulation as a target in chronic pain control. Br J Pharmacol 2018; 175 (12) 2173-2184
- 31 Pfau G, Brinkers M, Treuheit T, Kretzschmar M, Sentürk M, Hachenberg T. Misoprostol as a therapeutic option for trigeminal neuralgia in patients with multiple sclerosis. Pain Med 2012; 13 (10) 1377-1378
- 32 Bogduk N. Pulsed radiofrequency. Pain Med 2006; 7 (05) 396-407
- 33 Liao C, Visocchi M, Yang M, Liu P, Li S, Zhang W. Pulsed radiofrequency: a management option for recurrent trigeminal neuralgia following radiofrequency thermocoagulation. World Neurosurg 2017; 97: 760.e5-760.e7
- 34 Gao L, Chen RW, Williams JP. et al. Efficacy and safety of percutaneous ozone injection around gasserian ganglion for the treatment of trigeminal neuralgia: a multicenter retrospective study. J Pain Res 2020; 13: 927-936
- 35 Zhou L, Shao Z, Ou S. Cryoanalgesia: electrophysiology at different temperatures. Cryobiology 2003; 46 (01) 26-32
- 36 Bansal V, Mowar A, Dubey P, Gupta S. Role of cryotherapy in trigeminal neuralgia with certain modifications: a long-term prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol 2020; 129 (04) 290-295
- 37 ClinicalTrials.gov. Transcranial magnetic stimulation (tms) for trigeminal neuralgia (TGN). Available at: https://clinicaltrials.gov/ct2/show/study/NCT04120129. Published October 9, 2019. Accessed December 28, 2020
- 38 Ben-Haim S, Mirzadeh Z, Rosenberg WS. Deep brain stimulation for intractable neuropathic facial pain. Neurosurg Focus 2018; 45 (02) E15
- 39 Gibson W, Wand BM, O’Connell NE. Transcutaneous electrical nerve stimulation (TENS) for neuropathic pain in adults. Cochrane Database Syst Rev 2017; 9: CD011976
- 40 Samosiuk IZ, Kozhanova AK, Samosiuk NI. Fiziopunkturnaia terapiia nevralgii troĭnichnogo nerva [Physiopuncture therapy of trigeminal neuralgia]. Vopr Kurortol Fizioter Lech Fiz Kult 2000; (06) 29-32
- 41 de Pedro M, López-Pintor RM, de la Hoz-Aizpurua JL, Casañas E, Hernández G. Efficacy of low-level laser therapy for the therapeutic management of neuropathic orofacial pain: a systematic review. J Oral Facial Pain Headache 2020; 34 (01) 13-30
- 42 Sessirisombat S. Carbon-dioxide laser in the treatment of trigeminal neuralgia: a preliminary study. J Interdiscipl Med Dent Sci 2017; 5: 208
- 43 Reeves KD, Lyftogt J. Prolotherapy: regenerative injection therapy. In: Waldman SD, ed. Pain Management. 2nd ed. Philadelphia, PA: Saunders (Elsevier) 2011: 1027-44
- 44 Khandelwal A, Rath GP. Neural prolotherapy for trigeminal neuralgia. In: Rath GP, ed. Handbook of Trigeminal Neuralgia. Singapore: Springer Nature 2019: 201-205
- 45 Jie H, Xuanchen Z, Deheng L. et al. The long-term outcome of nerve combing for trigeminal neuralgia. Acta Neurochir (Wien) 2013; 155 (09) 1703-1708
- 46 Uppal V, Sondekoppam RV, Lobo CA, Kolli S, Kalagara HKP. Practice recommendations on neuraxial anesthesia and peripheral blocks during the COVID-19 pandemic. Available at: www.asra.com/covid-19/raguidance. Published March 27, 2020. Accessed December 28, 2020