CC BY-NC-ND 4.0 · AJP Rep 2021; 11(02): e61-e64
DOI: 10.1055/s-0041-1727261
Case Report

Refractory Pulmonary Interstitial Emphysema in Extreme Premature Newborn

1   Department of Pediatrics, Texas A&M Health Science Center, Baylor Scott & White McLane Children's Medical Center, Temple, Texas
,
Lea Mallett
1   Department of Pediatrics, Texas A&M Health Science Center, Baylor Scott & White McLane Children's Medical Center, Temple, Texas
,
Greg Miller
1   Department of Pediatrics, Texas A&M Health Science Center, Baylor Scott & White McLane Children's Medical Center, Temple, Texas
› Author Affiliations
Funding None.

Abstract

Pulmonary interstitial emphysema (PIE) occurs when air leaks into the pulmonary interstitium due to overdistension of distal airways, it occurs mainly in neonates with respiratory distress syndrome who need positive pressure ventilation but has also been reported in spontaneously breathing infants. Herein, we report on an extremely low birth weight infant with severe persistent PIE, while on invasive mechanical ventilation (high-frequency oscillatory ventilation, high-frequency jet ventilation, and neurally adjust ventilator assist) managed successfully with 2 weeks of selective right lung ventilation after failure of more conservative measures, including shorter periods of right mainstem intubation, before the prolonged trial that was successful.



Publication History

Received: 09 October 2020

Accepted: 08 December 2020

Article published online:
27 May 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Dembinski J, Heep A, Kau N, Knöpfle G, Bartmann P. CT imaging of pulmonary lobar interstitial emphysema in a spontaneous breathing preterm infant. Am J Perinatol 2002; 19 (06) 285-290
  • 2 Sheldon BK. Complications: bronchopulmonary dysplasia, air leak syndromes and retinopathy of prematurity. In: Goldsmith JP, Karotkin EH. eds. Assisted Ventilation of the Neonate. 3rd edition.. Philadelphia, PA: WB Saunders; 1996: 327-352
  • 3 Agrons GA, Courtney SE, Stocker JT, Markowitz RI. From the archives of the AFIP: Lung disease in premature neonates: radiologic-pathologic correlation. Radiographics 2005; 25 (04) 1047-1073
  • 4 Rao J, Hochman MI, Miller GG. Localized persistent pulmonary interstitial emphysema. J Pediatr Surg 2006; 41 (06) 1191-1193
  • 5 Berk DR, Varich LJ. Localized persistent pulmonary interstitial emphysema in a preterm infant in the absence of mechanical ventilation. Pediatr Radiol 2005; 35 (12) 1243-1245
  • 6 Gessler P, Toenz M, Gugger M, Pfenninger J. Lobar pulmonary interstitial emphysema in a premature infant on continuous positive airway pressure using nasal prongs. Eur J Pediatr 2001; 160 (04) 263-264
  • 7 Gürakan B, Tarcan A, Arda IS, Coşkun M. Persistent pulmonary interstitial emphysema in an unventilated neonate. Pediatr Pulmonol 2002; 34 (05) 409-411
  • 8 Greenough A, Dixon AK, Roberton NR. Pulmonary interstitial emphysema. Arch Dis Child 1984; 59 (11) 1046-1051
  • 9 Crosswell HE, Stewart DL. Special feature: radiological case of the month. Pulmonary interstitial emphysema in a nonventilated preterm infant. Arch Pediatr Adolesc Med 2001; 155 (05) 615-616
  • 10 Malkin S, Binns BAO. A case of spontaneous pneumothorax and pneumomediastinum in the newborn. Can Med Assoc J 1962; 86 (04) 183-185
  • 11 Stocker JT, Madewell JE. Persistent interstitial pulmonary emphysema: another complication of the respiratory distress syndrome. Pediatrics 1977; 59 (06) 847-857
  • 12 Greenough A, Mildner AD. Pulmonary disease of the newborn. Acute respiratory disease. In: Rennie RM. ed. Roberton's Textbook of Neonatology. 4th ed.. Philadelphia, PA: Elsevier; 2005: 468-553
  • 13 Harris TR, Wood BR. Physiological principles. In: Goldsmith JP, Karotkin EH. editors. Assisted Ventilation of the Neonate. 3rd ed.. Philadelphia, PA: WB Saunders; 1996: 21-68
  • 14 Wilmott R, Bush A, Deterding R. et al. Kendig's Disorders of the Respiratory Tract in Children. 9th ed.. Philadelphia, PA: Elsevier; 2018
  • 15 Perea L, Blinman T, Piccione J, Laje P. Bilateral congenital lobar emphysema: staged management. J Pediatr Surg 2017; 52 (09) 1442-1445 [Medline]
  • 16 Doyle LW, Davis PG, Morley CJ, McPhee A, Carlin JB. DART Study Investigators. Low-dose dexamethasone facilitates extubation among chronically ventilator-dependent infants: a multicenter, international, randomized, controlled trial. Pediatrics 2006; 117 (01) 75-83
  • 17 Donnelly LF, Lucaya J, Ozelame V. et al. CT findings and temporal course of persistent pulmonary interstitial emphysema in neonates: a multiinstitutional study. AJR Am J Roentgenol 2003; 180 (04) 1129-1133
  • 18 Heneghan MA, Sosulski R, Alarcon MB. Early pulmonary interstitial emphysema in the newborn: a grave prognostic sign. Clin Pediatr (Phila) 1987; 26 (07) 361-365
  • 19 Hart SM, McNair M, Gamsu HR, Price JF. Pulmonary interstitial emphysema in very low birthweight infants. Arch Dis Child 1983; 58 (08) 612-615
  • 20 Verma RP, Chandra S, Niwas R, Komaroff E. Risk factors and clinical outcomes of pulmonary interstitial emphysema in extremely low birth weight infants. J Perinatol 2006; 26 (03) 197-200
  • 21 Gaylord MS, Thieme RE, Woodall DL, Quissell BJ. Predicting mortality in low-birth-weight infants with pulmonary interstitial emphysema. Pediatrics 1985; 76 (02) 219-224
  • 22 Morisot C, Kacet N, Bouchez MC. et al. Risk factors for fatal pulmonary interstitial emphysema in neonates. Eur J Pediatr 1990; 149 (07) 493-495
  • 23 Thayyil S, Nagakumar P, Gowers H, Sinha A. Optimal endotracheal tube tip position in extremely premature infants. Am J Perinatol 2008; 25 (01) 13-16
  • 24 Toledo Del Castillo B, Gordillo I, Rubio García E. et al. Diffuse persistent pulmonary interstitial emphysema secondary to mechanical ventilation in bronchiolitis. BMC Pulm Med 2016; 16 (01) 139
  • 25 Aiyoshi T, Masumoto K, Shinkai T. et al. Pulmonary interstitial emphysema due to respiratory syncytial virus infection. Pediatr Int (Roma) 2016; 58 (09) 916-919
  • 26 Stevens TP, Harrington EW, Blennow M, Soll RF. Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome. Cochrane Database Syst Rev 2007; (04) CD003063
  • 27 Donn SM. Assisted ventilation and its complications. Martin RJ, Fanaroff AA, Walsh MC. eds. Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. 10th ed.. Vol. 2. Philadelphia, PA: Saunders; 2014: 1107
  • 28 Bidiwala K, Mimouni F, Lorenz JM, Tsang RC. Lateral decubitus position and pulmonary interstitial emphysema. J Pediatr 1984; 105 (05) 847-848
  • 29 Cohen RS, Smith DW, Stevenson DK, Moskowitz PS, Graham CB. Lateral decubitus position as therapy for persistent focal pulmonary interstitial emphysema in neonates: a preliminary report. J Pediatr 1984; 104 (03) 441-443
  • 30 Chalak LF, Kaiser JR, Arrington RW. Resolution of pulmonary interstitial emphysema following selective left main stem intubation in a premature newborn: an old procedure revisited. Paediatr Anaesth 2007; 17 (02) 183-186
  • 31 Rent SM, Donn SM. Treatment of Severe Unilateral Pulmonary Interstitial Emphysema in a Preterm Infant. Clin Case Rep Int. 2017; 1: 1019
  • 32 Keszler M, Donn SM, Bucciarelli RL. et al. Multicenter controlled trial comparing high-frequency jet ventilation and conventional mechanical ventilation in newborn infants with pulmonary interstitial emphysema. J Pediatr 1991; 119 (1 Pt 1): 85-93
  • 33 Squires KA, De Paoli AG, Williams C, Dargaville PA. High-frequency oscillatory ventilation with low oscillatory frequency in pulmonary interstitial emphysema. Neonatology 2013; 104 (04) 243-249
  • 34 Ahluwalia JS, Rennie JM, Wells FC. Successful outcome of severe unilateral pulmonary interstitial emphysema after bi-lobectomy in a very low birthweight infant. J R Soc Med 1996; 89 (03) 167P-168P
  • 35 Jassal MS, Benson JE, Mogayzel Jr PJ. Spontaneous resolution of diffuse persistent pulmonary interstitial emphysema. Pediatr Pulmonol 2008; 43 (06) 615-619