Abstract
Objectives This study aimed to evaluate and compare various commercially available local anesthetic
solutions.
Materials and Methods A total of 150 commercially available local anesthetic cartridges of similar composition
(2% lidocaine with epinephrine 1:100,000) were randomly collected and divided into
3 groups. The designations of groups were selected from their product names such that
each group consisted of 60 cartridges. Group S (Septodont, France) Group M (Medicaine,
Korea) and Group H (HD-Caine, Pakistan). The samples were divided into five sub-groups,
each consisting of 10 cartridges from each group to investigate each parameter.
Results The acquired data was statistically analyzed and compared (using SPSS version 12).
Compositional analysis revealed a non-significant (P>0.05) difference when the three
Groups were compared with standard lidocaine and epinephrine solutions. The mean pH
values of samples from group S, M, and H respectively fell within the range of pH
values of commercially available solutions. Non-significant difference in EPT values
of Group S and H was found when efficacy was compared (p = 0.3), however a significant difference (p < 0.01) was observed in contrast to Group M. Anti-bacterial activity was observed
in all the group and a non-significant difference in cell viability values of Group
S and M was found (p = 0.6), while the difference was significant in comparison to Group H.
Conclusion Within the limitations of these investigations, it appears that the properties of
different manufacturers fall within the recommended ranges as mentioned in literature
and do not appear to be statistically different in the variables we have tested.
Keywords
dental local anesthesia - lidocaine - epinephrine - composition - pH - efficacy -
antibacterial activity and cytotoxicity