Critical Illness Myopathy in a Child with SARS-CoV-2 Infection

María Jiménez-Legido; Víctor Soto-Insuga; Manuel Luján-Bonete; Verónica Cantarín-Extremera; Beatriz Bernardino-Cuesta; David Mansilla-Lozano; Inés Leoz-Gordillo; Serafín Rodríguez-Palero; Silvia Buendía-Martínez; Anna Duat-Rodríguez; María Luz Ruíz-Falcó-Rojas

doi:10.1055/s-0041-1728700

Journal of Pediatric Neurology, Inhaltsverzeichnis

Journal of Pediatric Neurology 2022; 20(05): 330-335
DOI: 10.1055/s-0041-1728700

Case Report

Critical Illness Myopathy in a Child with SARS-CoV-2 Infection

María Jiménez-Legido‡^*

¹Department of Neuropediatrics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

,

Víctor Soto-Insuga‡^*

¹Department of Neuropediatrics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

,

Manuel Luján-Bonete

²Department of Neurophysiology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

,

Verónica Cantarín-Extremera

¹Department of Neuropediatrics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

³Clinical Group linked (GCV14/ER/6) affiliated with the Networked Biomedical Research Centre for rare Diseases (CIBERER), Carlos III Health Institute, Madrid, Spain

,

Beatriz Bernardino-Cuesta

¹Department of Neuropediatrics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

,

David Mansilla-Lozano

²Department of Neurophysiology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

,

Inés Leoz-Gordillo

⁴Pediatric Intensive Care Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

,

Serafín Rodríguez-Palero

⁵Pediatric Rehabilitation Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

,

Silvia Buendía-Martínez

⁶Clinical Biochemist, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

,

Anna Duat-Rodríguez

¹Department of Neuropediatrics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

,

María Luz Ruíz-Falcó-Rojas

¹Department of Neuropediatrics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

³Clinical Group linked (GCV14/ER/6) affiliated with the Networked Biomedical Research Centre for rare Diseases (CIBERER), Carlos III Health Institute, Madrid, Spain

› Institutsangaben

Abstract

A variety of symptoms affecting the nervous system and/or skeletal muscle have been described during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. Though largely unexplored in children, intensive care unit-acquired weakness (ICU-AW) is associated with significant comorbidities. No previous pediatric cases of ICU-AW associated with coronavirus disease 2019 have been reported. A 12-year-old boy with SARS-CoV-2 infection developed systemic inflammatory response syndrome. Seven days later, he developed severe muscle weakness, with a creatine kinase level of 402 U/L. Nerve conduction studies and electromyography revealed a myopathic pattern. Severe pediatric cases of SARS-CoV-2 infection may develop ICU-AW. Early diagnosis and rehabilitation may decrease comorbidity and improve quality of life.

Keywords

SARS-CoV-2 - COVID-19 - critical illness myopathy - intensive care unit-acquired weakness - rehabilitation

Volltext

Referenzen

References
1 Zhai P, Ding Y, Wu X, Long J, Zhong Y, Li Y. The epidemiology, diagnosis and treatment of COVID-19. Int J Antimicrob Agents 2020; 55 (05) 105955
2 Mao L, Jin H, Wang M. et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020; 77 (06) 683-690
3 Guidon AC, Amato AA. COVID-19 and neuromuscular disorders. Neurology 2020; 94 (22) 959-969
4 Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G. Clinical review: critical illness polyneuropathy and myopathy. Crit Care 2008; 12 (06) 238
5 Weber-Carstens S, Deja M, Koch S. et al. Risk factors in critical illness myopathy during the early course of critical illness: a prospective observational study. Crit Care 2010; 14 (03) R119
6 Field-Ridley A, Dharmar M, Steinhorn D, McDonald C, Marcin JP. ICU-Acquired weakness is associated with differences in clinical outcomes in critically ill children. Pediatr Crit Care Med 2016; 17 (01) 53-57
7 Banwell BL, Mildner RJ, Hassall AC, Becker LE, Vajsar J, Shemie SD. Muscle weakness in critically ill children. Neurology 2003; 61 (12) 1779-1782
8 Batt J, dos Santos CC, Cameron JI, Herridge MS. Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms. Am J Respir Crit Care Med 2013; 187 (03) 238-246
9 Williams S, Horrocks IA, Ouvrier RA, Gillis J, Ryan MM. Critical illness polyneuropathy and myopathy in pediatric intensive care: a review. Pediatr Crit Care Med 2007; 8 (01) 18-22
10 Berek K, Margreiter J, Willeit J, Berek A, Schmutzhard E, Mutz NJ. Polyneuropathies in critically ill patients: a prospective evaluation. Intensive Care Med 1996; 22 (09) 849-855
11 Vondracek P, Bednarik J. Clinical and electrophysiological findings and long-term outcomes in paediatric patients with critical illness polyneuromyopathy. Eur J Paediatr Neurol 2006; 10 (04) 176-181
12 Smith CC, Bevelaqua AC. Challenging pain syndromes: Parsonage-Turner syndrome. Phys Med Rehabil Clin N Am 2014; 25 (02) 265-277
13 de Letter MA, Schmitz PI, Visser LH. et al. Risk factors for the development of polyneuropathy and myopathy in critically ill patients. Crit Care Med 2001; 29 (12) 2281-2286
14 Deza Leon MP, Redzepi A, McGrath E. et al. COVID-19-associated pediatric multisystem inflammatory syndrome. J Pediatric Infect Dis Soc 2020; 9 (03) 407-408
15 Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci 2020; 11 (07) 995-998
16 Ding Y, He L, Zhang Q. et al. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J Pathol 2004; 203 (02) 622-630
17 Tsai LK, Hsieh ST, Chao CC. et al. Neuromuscular disorders in severe acute respiratory syndrome. Arch Neurol 2004; 61 (11) 1669-1673
18 Fletcher SN, Kennedy DD, Ghosh IR. et al. Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness. Crit Care Med 2003; 31 (04) 1012-1016
19 Kress JP, Hall JB. ICU-acquired weakness and recovery from critical illness. N Engl J Med 2014; 370 (17) 1626-1635
20 Herridge MS, Tansey CM, Matté A. et al; Canadian Critical Care Trials Group. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 2011; 364 (14) 1293-1304
21 Thomas P, Baldwin C, Bissett B. et al. Physiotherapy management for COVID-19 in the acute hospital setting: clinical practice recommendations. J Physiother 2020; 66 (02) 73-82 . Doi: 20.03.011
22 World Health Organization. Clinical management of Severe Acute Respiratory İnfection (SARI) when COVID-19 disease is suspected. Interim Guidance; March 13, 2020. Available at: https://apps.who.int/iris/handle/10665/331446