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CC BY-NC-ND 4.0 · Eur J Dent 2021; 15(04): 768-775
DOI: 10.1055/s-0041-1729139
Review Article

Periodontal Diseases and COVID-19: A Scoping Review

Lisa Basso   *
1   Laboratoire des Multimatériaux et Interfaces, Claude Bernard University Lyon 1, Villeurbanne, France
,
Doriane Chacun   *
1   Laboratoire des Multimatériaux et Interfaces, Claude Bernard University Lyon 1, Villeurbanne, France
2   Faculty of Odontology, Claude Bernard University Lyon 1, Lyon, France
3   Hospices Civils de Lyon, Service de Consultations et de Traitements Dentaires, Unité Fonctionnelle de Parodontologie, Lyon, France
,
Kadiatou Sy
2   Faculty of Odontology, Claude Bernard University Lyon 1, Lyon, France
3   Hospices Civils de Lyon, Service de Consultations et de Traitements Dentaires, Unité Fonctionnelle de Parodontologie, Lyon, France
4   INSERM, Controlled Drug Delivery Systems and Biomaterials, University of Lille, France
,
Brigitte Grosgogeat
1   Laboratoire des Multimatériaux et Interfaces, Claude Bernard University Lyon 1, Villeurbanne, France
2   Faculty of Odontology, Claude Bernard University Lyon 1, Lyon, France
5   Hospices Civils de Lyon, Service de Consultations et de Traitements Dentaires, Clinical Research Unit, Lyon, Lyon France
,
Kerstin Gritsch 
1   Laboratoire des Multimatériaux et Interfaces, Claude Bernard University Lyon 1, Villeurbanne, France
2   Faculty of Odontology, Claude Bernard University Lyon 1, Lyon, France
3   Hospices Civils de Lyon, Service de Consultations et de Traitements Dentaires, Unité Fonctionnelle de Parodontologie, Lyon, France
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Abstract

The aim of this scoping review was to present the existing literature regarding the relationship between periodontal diseases and coronavirus disease 2019 (COVID-19). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping review guidelines was followed. Articles were retrieved from PubMed/MEDLINE and Scopus databases and screened to include studies relating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 to periodontal cells and/or tissues and/or diseases. Twenty-five papers were included; consisting of six reviews, seven original articles, six short reports, four letters to the editor, one commentary, and one case report. The articles were allocated to three different topics: (i) hypotheses on the relationship between periodontal diseases and COVID-19; (ii) risk factors and comorbidities common to periodontitis and COVID-19; (iii) periodontal manifestations of COVID-19. Certain molecules (angiotensin-converting enzyme-2, furin, cathepsin, TMPRSS2...) that are found at a high level in periodontal tissues, particularly in patients with periodontitis, are involved in the mechanism of entry of SARS-CoV-2 into cells. Periodontopathic bacteria could also play a direct role in the mechanism of entry of SARS-CoV-2 by cleaving the S-protein, and the cytokines produced during periodontitis could add to the cytokine storm found in the severe forms of COVID-19. It thus appears that the treatment of periodontitis, which allows a reduction in periodontopathic bacteria and of the local and systemic inflammation state, could be part of a strategy to prevent the development of severe forms of COVID-19.

Keywords

coronavirus - risk factors - oral health - periodontitis

* *These are the co-first authors for this article.




Publication History

Article published online:
09 September 2021

© 2021. European Journal of Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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