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DOI: 10.1055/s-0041-1729174
Cerebral Abscess Caused by Listeria monocytogenes: Case Report and Literature Review
Funding None.![](https://www.thieme-connect.de/media/jnlsa/202202/lookinside/thumbnails/10-1055-s-0041-1729174_202899cr-1.jpg)
Abstract
Background Listeria monocytogenes is an opportunistic gram-positive, facultative intracellular bacterium that causes invasive diseases mostly in pregnant women and immunosuppressed patients. Despite the predilection toward the central nervous system (CNS), it usually causes meningitis and meningoencephalitis, whereas brain abscesses are very uncommon.
Case presentation We describe the case of a 69-year-old homeless patient with a brain abscess due to L. monocytogenes who was successfully treated surgically by a guided stereotactic aspiration and antibiotic therapy with ampicillin and gentamicin. Our patient was discharged after 4 weeks of therapy without neurologic deficits. Additionally, we provide a review of the literature of brain abscesses caused by L. monocytogenes.
Conclusions This case highlights the need to drain cerebral abscesses and culture pus to correctly treat patients with antibiotics, especially given the high mortality rate of this infectious entity.
Ethics Approval and Consent to Participate
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Consent for Publication
Written informed consent was obtained from the patient for publication.
Availability of Data and Materials
All data analyzed during the current study are included in this study and are available from the corresponding author.
Author's Contribution
DC, MT, KJB, ER, DW, JB, and OS treated the patient and contributed to the writing, review, and revision of the manuscript. All authors have read and approved the final manuscript.
Publication History
Received: 08 September 2020
Accepted: 29 December 2020
Article published online:
08 September 2021
© 2021. Thieme. All rights reserved.
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References
- 1 Alvis Miranda H, Castellar-Leones SM, Elzain MA, Moscote-Salazar LR. Brain abscess: current management. J Neurosci Rural Pract 2013; 4 (Suppl. 01) S67-S81
- 2 Moorthy RK, Rajshekhar V. Management of brain abscess: an overview. Neurosurg Focus 2008; 24 (06) E3
- 3 Brouwer MC, Tunkel AR, van de Beek D. Brain abscess. N Engl J Med 2014; 371 (18) 1758
- 4 Dee RR, Lorber B. Brain abscess due to Listeria monocytogenes: case report and literature review. Rev Infect Dis 1986; 8 (06) 968-977
- 5 Drevets DA, Bronze MS. Listeria monocytogenes: epidemiology, human disease, and mechanisms of brain invasion. FEMS Immunol Med Microbiol 2008; 53 (02) 151-165
- 6 Bojanowski MW, Seizeur R, Effendi K, Bourgouin P, Magro E, Letourneau-Guillon L. Spreading of multiple Listeria monocytogenes abscesses via central nervous system fiber tracts: case report. J Neurosurg 2015; 123 (06) 1593-1599
- 7 Eckburg PB, Montoya JG, Vosti KL. Brain abscess due to Listeria monocytogenes: five cases and a review of the literature. Medicine (Baltimore) 2001; 80 (04) 223-235
- 8 Brouwer MC, van de Beek D, Heckenberg SG, Spanjaard L, de Gans J. Community-acquired Listeria monocytogenes meningitis in adults. Clin Infect Dis 2006; 43 (10) 1233-1238
- 9 Cone LA, Leung MM, Byrd RG, Annunziata GM, Lam RY, Herman BK. Multiple cerebral abscesses because of Listeria monocytogenes: three case reports and a literature review of supratentorial listerial brain abscess(es). Surg Neurol 2003; 59 (04) 320-328
- 10 Tiri B, Priante G, Saraca LM, Martella LA, Cappanera S, Francisci D. Listeria monocytogenes brain abscess: controversial issues for the treatment—two cases and literature review. Case Rep Infect Dis 2018; 2018: 6549496
- 11 Nau R. S1-Leitlinie Hirnabszess, Deutsche Gesellschaft für Neurologie, Hrsg. Leitlinien für Diagnostik und Therapie in der Neurologie. Online: www.dgn.org/leitlinien 2016
- 12 van de Beek D, de Gans J, Tunkel AR, Wijdicks EF. Community-acquired bacterial meningitis in adults. N Engl J Med 2006; 354 (01) 44-53
- 13 Disson O, Lecuit M. Targeting of the central nervous system by Listeria monocytogenes . Virulence 2012; 3 (02) 213-221
- 14 Charlier C, Perrodeau É, Leclercq A. et al; MONALISA study group. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study. Lancet Infect Dis 2017; 17 (05) 510-519
- 15 Brouwer MC, van de Beek D. MONALISA: a grim picture of listeriosis. Lancet Infect Dis 2017; 17 (05) 464-466
- 16 Oevermann A, Di Palma S, Doherr MG, Abril C, Zurbriggen A, Vandevelde M. Neuropathogenesis of naturally occurring encephalitis caused by Listeria monocytogenes in ruminants. Brain Pathol 2010; 20 (02) 378-390
- 17 Antal EA, Dietrichs E, Løberg EM, Melby KK, Maehlen J. Brain stem encephalitis in listeriosis. Scand J Infect Dis 2005; 37 (03) 190-194
- 18 Listeriosis LB. Clin Infect Dis 1997; 24 (01) 1-9 , quiz 10–11
- 19 de Noordhout CM, Devleesschauwer B, Angulo FJ. et al. The global burden of listeriosis: a systematic review and meta-analysis. Lancet Infect Dis 2014; 14 (11) 1073-1082
- 20 Vázquez-Boland JA, Krypotou E, Scortti M. Listeria placental infection. MBio 2017; 8 (03) e00949-17
- 21 West JA, Onofrio AR, Martinez LC, Opatowsky MJ, Spak CW, Layton KF. Solitary supratentorial Listeria monocytogenes brain abscess in an immunocompromised patient. Proc Bayl Univ Med Cent 2015; 28 (03) 337-339
- 22 Matera G, Puccio R, Giancotti A. et al. Multiple abscesses of the left brain hemisphere due to Listeria monocytogenes in an immunocompromised patient: a case report. Infez Med 2012; 20 (04) 279-283
- 23 van de Beek D, Cabellos C, Dzupova O. et al; ESCMID Study Group for Infections of the Brain (ESGIB). ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. Clin Microbiol Infect 2016; 22 (Suppl. 03) S37-S62
- 24 Amaya-Villar R, García-Cabrera E, Sulleiro-Igual E. et al. Three-year multicenter surveillance of community-acquired Listeria monocytogenes meningitis in adults. BMC Infect Dis 2010; 10: 324
- 25 Mitjà O, Pigrau C, Ruiz I. et al. Predictors of mortality and impact of aminoglycosides on outcome in listeriosis in a retrospective cohort study. J Antimicrob Chemother 2009; 64 (02) 416-423
- 26 Hof H. An update on the medical management of listeriosis. Expert Opin Pharmacother 2004; 5 (08) 1727-1735
- 27 Hof H, Nichterlein T, Kretschmar M. Management of listeriosis. Clin Microbiol Rev 1997; 10 (02) 345-357
- 28 Widdrington JD, Bond H, Schwab U. et al. Pyogenic brain abscess and subdural empyema: presentation, management, and factors predicting outcome. Infection 2018; 46 (06) 785-792
- 29 Arlotti M, Grossi P, Pea F. et al; GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) Working Group on Brain Abscesses. Consensus document on controversial issues for the treatment of infections of the central nervous system: bacterial brain abscesses. Int J Infect Dis 2010; 14 (Suppl. 04) S79-S92
- 30 Cavuşoglu H, Kaya RA, Türkmenoglu ON, Colak I, Aydin Y. Brain abscess: analysis of results in a series of 51 patients with a combined surgical and medical approach during an 11-year period. Neurosurg Focus 2008; 24 (06) E9
- 31 Buchner LH, Schneierson S. Clinical and laboratory aspects of Listeria monocytogenes infections. With a report of ten cases. Am J Med 1968; 45 (06) 904-921
- 32 Spilkin ES, Rachmaninoff N, Climie AR. Listeria monocytogenes meningitis. Report of 2 cases and review of the literatur. Am J Clin Pathol 1968; 49 (05) 671-676
- 33 Kwantes W, Isaac M. Listeriosis. BMJ 1971; 4 (5782): 296-297
- 34 Halkin H, Shacked IJ, Altmann G. Brain abscess due to Listeria monocytogenes in a patient with cirrhosis of the liver. Isr J Med Sci 1971; 7 (10) 1192-1195
- 35 Chow AW, Alexander E, Montgomerie JZ, Guze LB. Successful treatment of non-meningitic listerial brain abscess without operation. West J Med 1975; 122 (02) 167-171
- 36 Crocker EF, Leicester J. Cerebral abscess due to Listeria monocytogenes . Med J Aust 1976; 1 (04) 90-92
- 37 Larsson S, Cronberg S, Winblad S. Clinical aspects on 64 cases of juvenile and adult listeriosis in Sweden. Acta Med Scand 1978; 204 (06) 503-508
- 38 Umenai T, Saitoh Y, Sasaki T. et al. Listeria monocytogenes infection with brain abscess formation: the first case in Miyagi Prefecture. Tohoku J Exp Med 1978; 124 (01) 95-96
- 39 Larsson S, Linell F. Correlations between clinical and postmortem findings in listeriosis. Scand J Infect Dis 1979; 11 (01) 55-58
- 40 Kennard C, Howard AJ, Scholtz C, Swash M. Infection of the brainstem by Listeria monocytogenes . J Neurol Neurosurg Psychiatry 1979; 42 (10) 931-933
- 41 Dykes A, Baraff LJ, Herzog P. Listeria brain abscess in an immunosuppressed child. J Pediatr 1979; 94 (01) 72-74
- 42 Lechtenberg R, Sierra MF, Pringle GF, Shucart WA, Butt KM. Listeria monocytogenes: brain abscess or meningoencephalitis?. Neurology 1979; 29 (01) 86-90
- 43 Stam J, Wolters EC, van Manen J, Verbeeten B. Listeria monocytogenes abscess in the basal ganglia. J Neurol Neurosurg Psychiatry 1982; 45 (08) 757-759
- 44 Hutchinson RJ, Heyn RM. Listerial brain abscess in a patient with leukemia: successful nonsurgical management. Clin Pediatr (Phila) 1983; 22 (04) 312
- 45 Pollock SS, Pollock TM, Harrison MJ. Infection of the central nervous system by Listeria monocytogenes: a review of 54 adult and juvenile cases. Q J Med 1984; 53 (211) 331-340
- 46 Brun-Buisson CJ, de Gialluly E, Gherardi R, Otterbein G, Gray F, Rapin M. Fatal nonmeningitic Listeria rhombencephalitis. Report of two cases. Arch Intern Med 1985; 145 (11) 1982-1985
- 47 Cosín Ochaita J, Solares J, Romero Vivas J, Rodríguez-Creixems M, Pasquau F, Bouza E. Cerebral Listeria abscess. Rev Clin Esp 1986; 179 (05) 256-258
- 48 Leung R, Woo E, Yu YL, Huang CY. Listeria brain abscess associated with steroid therapy: successful non-surgical treatment. Clin Exp Neurol 1987; 24: 181-186
- 49 Patey O, Nedelec C, Emond JP, Mayorga R, N'Go N, Lafaix C. Listeria monocytogenes septicemia in an AIDS patient with a brain abscess. Eur J Clin Microbiol Infect Dis 1989; 8 (08) 746-748
- 50 Harris JO, Marquez J, Swerdloff MA, Magana IA. Listeria brain abscess in the acquired immunodeficiency syndrome. Arch Neurol 1989; 46 (03) 250
- 51 Mancini J, Choux M, Pinsard N. A cerebral abscess due to Listeria monocytogenes in a 15-month-old infant. Ann Pediatr (Paris) 1990; 37 (05) 299-302
- 52 Updike WS, Anderson CJ, Lundberg MS, Spruance SL. Successful medical treatment of listerial brain abscess. West J Med 1990; 152 (03) 298-301
- 53 Brown PH, Ingram CW, van der Horst C. Brain abscess caused by Listeria monocytogenes . Rev Infect Dis 1991; 13 (04) 768-769
- 54 Viscoli C, Garaventa A, Ferrea G, Manno G, Taccone A, Terragna A. Listeria monocytogenes brain abscesses in a girl with acute lymphoblastic leukaemia after late central nervous system relapse. Eur J Cancer 1991; 27 (04) 435-437
- 55 Soto LF, Sliman RJ. Focal seizures in a man with multiple medical problems. Hosp Pract (Off Ed) 1992; 27 (03) 27-29
- 56 Sivalingam JJ, Martin P, Fraimow HS, Yarze JC, Friedman LS. Listeria monocytogenes peritonitis: case report and literature review. Am J Gastroenterol 1992; 87 (12) 1839-1845
- 57 Poropatich R, Phillips YY. Listerial brain abscess in long-standing sarcoidosis. South Med J 1992; 85 (05) 554-556
- 58 Cleveland KO, Gelfand MS. Listerial brain abscess in a patient with chronic lymphocytic leukemia treated with fludarabine. Clin Infect Dis 1993; 17 (04) 816-817
- 59 Sjöström A, Olsson T, Burman LA, Tärnvik A. Listerial brain abscess in an immunocompetent adult with a predisposing intestinal condition. J Infect 1995; 30 (02) 185-186
- 60 Turner D, Fried M, Hoffman M, Paleacu D, Reider I, Yust I. Brainstem abscess and meningitis due to Listeria monocytogenes in an adult with juvenile chronic arthritis. Neurology 1995; 45 (05) 1020-1021
- 61 Salgado MJ, Damani NN, Llewellyn CG, Maloney WJ, Vandorpe RA, Sangalang VE. Magnetic resonance imaging of abscesses of the brain stem and cerebellum complicating Listeria monocytogenes rhombencephalitis. Can Assoc Radiol J 1996; 47 (06) 431-433
- 62 Douen AG, Bourque PR. Musical auditory hallucinosis from Listeria rhombencephalitis. Can J Neurol Sci 1997; 24 (01) 70-72
- 63 Ornaque I, Vallderiola F, González J, Zavala E. Acute hydrocephalus and brain abscess in Listeria monocytogenes meningitis. Neurologia 1997; 12 (07) 317-318
- 64 Mylonakis E, Hohmann EL, Calderwood SB. Central nervous system infection with Listeria monocytogenes. 33 years' experience at a general hospital and review of 776 episodes from the literature. Medicine (Baltimore) 1998; 77 (05) 313-336
- 65 Antunes NL, Hariharan S, DeAngelis LM. Brain abscesses in children with cancer. Med Pediatr Oncol 1998; 31 (01) 19-21
- 66 Banerji A, Noya FJ. Brain abscess associated with neonatal listeriosis. Pediatr Infect Dis J 1999; 18 (03) 305-307
- 67 Takano A, Adachi H, Mizuno M, Kawamura K, Sobue G. Direct Gram staining of blood culture sample enabled the early diagnosis of brain abscess due to Listeria monocytogenes . Rinsho Shinkeigaku 1999; 39 (11) 1164-1167
- 68 Ackermann G, Schoen H, Schaumann R, Dietrich J, Rodloff AC. Rapidly growing tumor-like brain lesion. Infection 2001; 29 (05) 278-279
- 69 Mrowka M, Graf LP, Odin P. MRI findings in mesenrhombencephalitis due to Listeria monocytogenes . J Neurol Neurosurg Psychiatry 2002; 73 (06) 775
- 70 Maezawa Y, Hirasawa A, Abe T. et al. Successful treatment of listerial brain abscess: a case report and literature review. Intern Med 2002; 41 (11) 1073-1078
- 71 Leiti O, Gross JW, Tuazon CU. Treatment of brain abscess caused by Listeria monocytogenes in a patient with allergy to penicillin and trimethoprim-sulfamethoxazole. Clin Infect Dis 2005; 40 (06) 907-908
- 72 Smiatacz T, Kowalik MM, Hlebowicz M. Prolonged dysphagia due to Listeria-rhombencephalitis with brainstem abscess and acute polyradiculoneuritis. J Infect 2006; 52 (06) e165-e167
- 73 Ganière V, Christen G, Bally F. et al. Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide. Nat Clin Pract Oncol 2006; 3 (06) 339-343 , quiz 343
- 74 Treebupachatsakul P, Srifeungfung S, Chayakulkeeree M. Brain abscess due to Listeria monocytogenes: first case report in Thailand. J Med Assoc Thai 2006; 89 (09) 1516-1520
- 75 Soares-Fernandes JP, Beleza P, Cerqueira JJ. et al. Simultaneous supratentorial and brainstem abscesses due to Listeria monocytogenes . J Neuroradiol 2008; 35 (03) 173-176
- 76 Al-Khatti AA, Al-Tawfiq JA. Listeria monocytogenes brain abscess in a patient with multiple myeloma. J Infect Dev Ctries 2010; 4 (12) 849-851
- 77 Wu J, Fernandes-Alnemri T, Alnemri ES. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes . J Clin Immunol 2010; 30 (05) 693-702
- 78 Stefanovic A, Reid J, Nadon AC, Grant J. Potential nosocomial acquisition of epidemic Listeria monocytogenes presenting as multiple brain abscesses resembling nocardiosis. Can J Infect Dis Med Microbiol 2010; 21 (01) 57-60
- 79 Coste JF, Duval V, Nguyen Y. et al. Unusual location of a brain abscess due to Listeria monocytogenes . Pathol Biol (Paris) 2012; 60 (05) e45-e48
- 80 Gertz K, Siebert E, Halle E. et al. Multiple supratentorial brain abscesses due to Listeria monocytogenes in a patient with myasthenia gravis. Clin Neurol Neurosurg 2013; 115 (09) 1923-1924
- 81 Choudhury N, Khan AB, Tzvetanov I. et al. Cerebellar abscess caused by Listeria monocytogenes in a liver transplant patient. Transpl Infect Dis 2013; 15 (06) E224-E228
- 82 Tseng J, Strasfeld LM, Orloff SL. An unusual presentation of altered mental status after orthotopic liver transplantation: listeria brain abscess. Transplantation 2013; 95 (12) e72-e73
- 83 Beynon C, Neumann JO, Bösel J, Unterberg AW, Kiening KL. Stereotactic biopsy and drainage of a brainstem abscess caused by Listeria monocytogenes . Neurol Med Chir (Tokyo) 2013; 53 (04) 263-265
- 84 Horta-Baas G, Guerrero-Soto O, Barile-Fabris L. Central nervous system infection by Listeria monocytogenes in patients with systemic lupus erythematosus: analysis of 26 cases, including the report of a new case. Reumatol Clin 2013; 9 (06) 340-347
- 85 Limmahakhun S, Chayakulkeeree M. Listeria monocytogenes brain abscess: two cases and review of the literature. Southeast Asian J Trop Med Public Health 2013; 44 (03) 468-478
- 86 Perini G, Pravettoni R, Farina E, Grande G, Contri P, Mariani C. Listeria brain abscesses during administration of mycophenolate mofetil for systemic lupus erythematosus: a case report. Neurol Sci 2015; 36 (06) 1019-1020
- 87 Al-Harbi TM, Al-Muammar SA, Ellis RJ. Brain abscess following rituximab infusion in a patient with pemphigus vulgaris. Am J Case Rep 2015; 16: 65-68
- 88 DeJesus-Alvelo I, Merenda A. A case report of Listeria monocytogenes abscesses presenting as cortically predominant ring-enhancing lesions. Case Rep Neurol 2015; 7 (01) 105-109
- 89 Fervienza A, Bodro M, Castro P. et al. Brain abscess due to Listeria monocytogenes after HELLP syndrome in a patient with antiphospholipid syndrome. Lupus 2017; 26 (09) 1002-1004
- 90 Onder ME, Gun H, Kimyon G, Zengin O, Onat AM, Kisacik B. Brain abscesses due to Listeria monocytogenes after rituximab therapy. J Clin Rheumatol 2016; 22 (04) 233-234
- 91 Berry AC, Nguyen L, Yarbrough T, Iqbal F, Green WK. Ring-enhancing brain lesions: Listeria monocytogenes abscesses. Intern Emerg Med 2016; 11 (05) 763-765
- 92 Mano T, Saito M, Yoshizawa T. Axonal invasion of Listeria monocytogenes: Implications for early diagnosis with magnetic resonance imaging. J Neurol Sci 2017; 373: 7-8
- 93 Atsawarungruangkit A, Dominguez F, Borda G, Mavrogiorgos N. Listeria Monocytogenes brain abscess in Crohn's disease treated with adalimumab. Case Rep Gastroenterol 2017; 11 (03) 667-671
- 94 Dimou J, Kelly J. Concurrent diagnosis of Listeria monocytogenes meningo-encephalitis and glioblastoma: case report and review of the literature. Clin Oncol (R Coll Radiol) 2018