Clin Colon Rectal Surg 2021; 34(04): 251-261
DOI: 10.1055/s-0041-1729922
Review Article

Malignant Large Bowel Obstruction

Roberta L. Muldoon
1   Vanderbilt University Medical Center Nashville, Tennessee
› Author Affiliations

Abstract

Large bowel obstruction is a serious and potentially life-threatening surgical emergency which is associated with high morbidity and mortality rate. The most common etiology is colorectal cancer which accounts for over 60% of all large bowel obstructions. Proper assessment, thoughtful decision-making and prompt treatment is necessary to decrease the high morbidity and mortality which is associated with this entity. Knowledge of the key elements regarding the presentation of a patient with a large bowel obstruction will help the surgeon in formulating an appropriate treatment plan for the patient. Comprehensive knowledge and understanding of the various treatment options available is necessary when caring for these patients. This chapter will review the presentation of patients with malignant large bowel obstruction, discuss the various diagnostic modalities available, as well as discuss treatment options and the various clinical scenarios in which they are most appropriately utilized.



Publication History

Article published online:
20 July 2021

© 2021. Thieme. All rights reserved.

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  • References

  • 1 Rault A, Collet D, Sa Cunha A, Larroude D, Ndobo'epoy F, Masson B. Prise en charge du cancer colique en occlusion. Ann Chir 2005; 130 (05) 331-335
  • 2 Tan KK, Sim R. Surgery for obstructed colorectal malignancy in an Asian population: predictors of morbidity and comparison between left- and right-sided cancers. J Gastrointest Surg 2010; 14 (02) 295-302
  • 3 Aslar AK, Ozdemir S, Mahmoudi H, Kuzu MA. Analysis of 230 cases of emergent surgery for obstructing colon cancer—lessons learned. J Gastrointest Surg 2011; 15 (01) 110-119
  • 4 Jaffe T, Thompson WM. Large-bowel obstruction in the adult: classic radiographic and CT findings, etiology, and mimics. Radiology 2015; 275 (03) 651-663
  • 5 Boley SJ, Agrawal GP, Warren AR. et al. Pathophysiologic effects of bowel distention on intestinal blood flow. Am J Surg 1969; 117 (02) 228-234
  • 6 Saegesser F, Sandblom P. Ischemic lesions of the distended colon: a complication of obstructive colorectal cancer. Am J Surg 1975; 129 (03) 309-315
  • 7 Cappell MS, Batke M. Mechanical obstruction of the small bowel and colon. Med Clin North Am 2008; 92 (03) 575-597 , viii
  • 8 Melzig EP, Terz JJ. Pseudo-obstruction of the colon. Arch Surg 1978; 113 (10) 1186-1190
  • 9 Vanek VW, Al-Salti M. Acute pseudo-obstruction of the colon (Ogilvie's syndrome). An analysis of 400 cases. Dis Colon Rectum 1986; 29 (03) 203-210
  • 10 Saunders MD. Acute colonic pseudo-obstruction. Gastrointest Endosc Clin N Am 2007; 17 (02) 341-360 , vi–vii
  • 11 Yeo HL, Lee SW. Colorectal emergencies: review and controversies in the management of large bowel obstruction. J Gastrointest Surg 2013; 17 (11) 2007-2012
  • 12 Hayakawa K, Tanikake M, Yoshida S, Urata Y, Yamamoto E, Morimoto T. Radiological diagnosis of large-bowel obstruction: neoplastic etiology. Emerg Radiol 2013; 20 (01) 69-76
  • 13 Ericksen AS, Krasna MJ, Mast BA, Nosher JL, Brolin RE. Use of gastrointestinal contrast studies in obstruction of the small and large bowel. Dis Colon Rectum 1990; 33 (01) 56-64
  • 14 Frager D, Rovno HD, Baer JW, Bashist B, Friedman M. Prospective evaluation of colonic obstruction with computed tomography. Abdom Imaging 1998; 23 (02) 141-146
  • 15 Taourel P, Kessler N, Lesnik A, Pujol J, Morcos L, Bruel JM. Helical CT of large bowel obstruction. Abdom Imaging 2003; 28 (02) 267-275
  • 16 Ramanathan S, Ojili V, Vassa R, Nagar A. Large bowel obstruction in the emergency department: imaging spectrum of common and uncommon causes. J Clin Imaging Sci 2017; 7: 15
  • 17 Sabbagh C, Siembida N, Yzet T. et al. What are the predictive factors of caecal perforation in patients with obstructing distal colon cancer?. Colorectal Dis 2018; 20 (08) 688-695
  • 18 Orbion A, Mouman A, Behr J, Lakkis Z, Calame P, Delabrousse E. Correlation between a continent ileocecal valve and CT signs of severity in patients presenting with obstructive colonic cancer. Emerg Radiol 2019; 26 (03) 277-282
  • 19 Edwards DP, Leppington-Clarke A, Sexton R, Heald RJ, Moran BJ. Stoma-related complications are more frequent after transverse colostomy than loop ileostomy: a prospective randomized clinical trial. Br J Surg 2001; 88 (03) 360-363
  • 20 Harris DA, Egbeare D, Jones S, Benjamin H, Woodward A, Foster ME. Complications and mortality following stoma formation. Ann R Coll Surg Engl 2005; 87 (06) 427-431
  • 21 Hsu TC. Comparison of one-stage resection and anastomosis of acute complete obstruction of left and right colon. Am J Surg 2005; 189 (04) 384-387
  • 22 Frago R, Biondo S, Millan M. et al. Differences between proximal and distal obstructing colonic cancer after curative surgery. Colorectal Dis 2011; 13 (06) e116-e122
  • 23 Lee YM, Law WL, Chu KW, Poon RT. Emergency surgery for obstructing colorectal cancers: a comparison between right-sided and left-sided lesions. J Am Coll Surg 2001; 192 (06) 719-725
  • 24 Mege D, Manceau G, Beyer-Berjot L. et al; AFC (French Surgical Association) Working Group. Surgical management of obstructive right-sided colon cancer at a national level results of a multicenter study of the French Surgical Association in 776 patients. Eur J Surg Oncol 2018; 44 (10) 1522-1531
  • 25 Mege D, Manceau G, Beyer L. et al; AFC (French Surgical Association) Working Group. Right-sided vs. left-sided obstructing colonic cancer: results of a multicenter study of the French Surgical Association in 2325 patients and literature review. Int J Colorectal Dis 2019; 34 (06) 1021-1032
  • 26 Frasson M, Granero-Castro P, Ramos Rodríguez JL. et al; ANACO Study Group. Risk factors for anastomotic leak and postoperative morbidity and mortality after elective right colectomy for cancer: results from a prospective, multicentric study of 1102 patients. Int J Colorectal Dis 2016; 31 (01) 105-114
  • 27 Parthasarathy M, Greensmith M, Bowers D, Groot-Wassink T. Risk factors for anastomotic leakage after colorectal resection: a retrospective analysis of 17,518 patients. Colorectal Dis 2017; 19 (03) 288-298
  • 28 Voron T, Bruzzi M, Ragot E. et al. Anastomotic location predicts anastomotic leakage after elective colonic resection for cancer. J Gastrointest Surg 2019; 23 (02) 339-347
  • 29 Biondo S, Parés D, Frago R. et al. Large bowel obstruction: predictive factors for postoperative mortality. Dis Colon Rectum 2004; 47 (11) 1889-1897
  • 30 Runkel NS, Hinz U, Lehnert T, Buhr HJ, Herfarth Ch. Improved outcome after emergency surgery for cancer of the large intestine. Br J Surg 1998; 85 (09) 1260-1265
  • 31 Fielding LP, Stewart-Brown S, Blesovsky L. Large-bowel obstruction caused by cancer: a prospective study. BMJ 1979; 2 (6189): 515-517
  • 32 Carson SN, Poticha SM, Shields TW. Carcinoma obstructing the left side of the colon. Arch Surg 1977; 112 (04) 523-526
  • 33 Maggard MA, Zingmond D, O'Connell JB, Ko CY. What proportion of patients with an ostomy (for diverticulitis) get reversed?. Am Surg 2004; 70 (10) 928-931
  • 34 Zorcolo L, Covotta L, Carlomagno N, Bartolo DC. Safety of primary anastomosis in emergency colo-rectal surgery. Colorectal Dis 2003; 5 (03) 262-269
  • 35 Cunliffe WJ, Hasleton PS, Tweedle DE, Schofield PF. Incidence of synchronous and metachronous colorectal carcinoma. Br J Surg 1984; 71 (12) 941-943
  • 36 Arenas RB, Fichera A, Mhoon D, Michelassi F. Incidence and therapeutic implications of synchronous colonic pathology in colorectal adenocarcinoma. Surgery 1997; 122 (04) 706-709 , discussion 709–710
  • 37 Oya M, Takahashi S, Okuyama T, Yamaguchi M, Ueda Y. Synchronous colorectal carcinoma: clinico-pathological features and prognosis. Jpn J Clin Oncol 2003; 33 (01) 38-43
  • 38 Hennekinne-Mucci S, Tuech JJ, Bréhant O. et al. Emergency subtotal/total colectomy in the management of obstructed left colon carcinoma. Int J Colorectal Dis 2006; 21 (06) 538-541
  • 39 Muir EG. Safety in colonic resection. Proc R Soc Med 1968; 61 (04) 401-408
  • 40 Dudley HA, Racliffe AG, McGeehan D. Intraoperative irrigation of the colon to permit primary anastomosis. Br J Surg 1980; 67 (02) 80-81
  • 41 Ortiz H, Biondo S, Ciga MA, Kreisler E, Oteiza F, Fraccalvieri D. Comparative study to determine the need for intraoperative colonic irrigation for primary anastomosis in left-sided colonic emergencies. Colorectal Dis 2009; 11 (06) 648-652
  • 42 Awotar GK, Guan G, Sun W. et al. Reviewing the management of obstructive left colon cancer: assessing the feasibility of the one-stage resection and anastomosis after intraoperative colonic irrigation. Clin Colorectal Cancer 2017; 16 (02) e89-e103
  • 43 Hong Y, Nam S, Kang JG. The usefulness of intraoperative colonic irrigation and primary anastomosis in patients requiring a left colon resection. Ann Coloproctol 2017; 33 (03) 106-111
  • 44 Nyam DC, Seow-Choen F, Leong AF, Ho YH. Colonic decompression without on-table irrigation for obstructing left-sided colorectal tumours. Br J Surg 1996; 83 (06) 786-787
  • 45 Lim JF, Tang CL, Seow-Choen F, Heah SM. Prospective, randomized trial comparing intraoperative colonic irrigation with manual decompression only for obstructed left-sided colorectal cancer. Dis Colon Rectum 2005; 48 (02) 205-209
  • 46 Kam MH, Tang CL, Chan E, Lim JF, Eu KW. Systematic review of intraoperative colonic irrigation vs. manual decompression in obstructed left-sided colorectal emergencies. Int J Colorectal Dis 2009; 24 (09) 1031-1037
  • 47 Patriti A, Contine A, Carbone E, Gullà N, Donini A. One-stage resection without colonic lavage in emergency surgery of the left colon. Colorectal Dis 2005; 7 (04) 332-338
  • 48 You YN, Chua HK, Nelson H, Hassan I, Barnes SA, Harrington J. Segmental vs. extended colectomy: measurable differences in morbidity, function, and quality of life. Dis Colon Rectum 2008; 51 (07) 1036-1043
  • 49 Käser SA, Glauser PM, Künzli B, Dolanc R, Bassotti G, Maurer CA. Subtotal colectomy for malignant left-sided colon obstruction is associated with a lower anastomotic leak rate than segmental colectomy. Anticancer Res 2012; 32 (08) 3501-3505
  • 50 Torralba JA, Robles R, Parrilla P. et al. Subtotal colectomy vs. intraoperative colonic irrigation in the management of obstructed left colon carcinoma. Dis Colon Rectum 1998; 41 (01) 18-22
  • 51 Single-stage treatment for malignant left-sided colonic obstruction: a prospective randomized clinical trial comparing subtotal colectomy with segmental resection following intraoperative irrigation. The SCOTIA Study Group. Subtotal Colectomy versus On-table Irrigation and Anastomosis. Br J Surg 1995; 82 (12) 1622-1627
  • 52 Lee HJ, Hong SP, Cheon JH, Kim TI, Kim WH, Park SJ. Clinical outcomes of self-expandable metal stents for malignant rectal obstruction. Dis Colon Rectum 2018; 61 (01) 43-50
  • 53 Dalal KM, Gollub MJ, Miner TJ. et al. Management of patients with malignant bowel obstruction and stage IV colorectal cancer. J Palliat Med 2011; 14 (07) 822-828
  • 54 Ohman U. Prognosis in patients with obstructing colorectal carcinoma. Am J Surg 1982; 143 (06) 742-747
  • 55 Umpleby HC, Williamson RC. Survival in acute obstructing colorectal carcinoma. Dis Colon Rectum 1984; 27 (05) 299-304
  • 56 Lavanchy JL, Vaisnora L, Haltmeier T. et al. Oncologic long-term outcomes of emergency versus elective resection for colorectal cancer. Int J Colorectal Dis 2019; 34 (12) 2091-2099
  • 57 Manceau G, Voron T, Mege D. et al; AFC (French Surgical Association) Working Group. Prognostic factors and patterns of recurrence after emergency management for obstructing colon cancer: multivariate analysis from a series of 2120 patients. Langenbecks Arch Surg 2019; 404 (06) 717-729
  • 58 Carraro PG, Segala M, Cesana BM, Tiberio G. Obstructing colonic cancer: failure and survival patterns over a ten-year follow-up after one-stage curative surgery. Dis Colon Rectum 2001; 44 (02) 243-250
  • 59 Petrelli F, Tomasello G, Borgonovo K. et al. Prognostic survival associated with left-sided vs right-sided colon cancer: a systematic review and meta-analysis. JAMA Oncol 2017; 3 (02) 211-219
  • 60 Faucheron JL, Paquette B, Trilling B, Heyd B, Koch S, Mantion G. Emergency surgery for obstructing colonic cancer: a comparison between right-sided and left-sided lesions. Eur J Trauma Emerg Surg 2018; 44 (01) 71-77
  • 61 Wang HS, Lin JK, Mou CY. et al. Long-term prognosis of patients with obstructing carcinoma of the right colon. Am J Surg 2004; 187 (04) 497-500