Abstract
Obesity is a multifactorial disease with a variable and underwhelming weight loss
response to current treatment approaches. Precision medicine proposes a new paradigm
to improve disease classification based on the premise of human heterogeneity, with
the ultimate goal of maximizing treatment effectiveness, tolerability, and safety.
Recent advances in high-throughput biochemical assays have contributed to the partial
characterization of obesity's pathophysiology, as well as to the understanding of
the role that intrinsic and environmental factors, and their interaction, play in
its development and progression. These data have led to the development of biological
markers that either are being or will be incorporated into strategies to develop personalized
lines of treatment for obesity. There are currently many ongoing initiatives aimed
at this; however, much needs to be resolved before precision obesity medicine becomes
common practice. This review aims to provide a perspective on the currently available
data of high-throughput technologies to treat obesity.
Keywords
phenotypes - ADOPT - genetics - microbiome
