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CC BY 4.0 · Rev Bras Ginecol Obstet 2021; 43(06): 429-435
DOI: 10.1055/s-0041-1730288
Original Article
Obstetrics

Evaluation of the Blood Level of Adiponectin in Pregnant Adolescents

Avaliação dos níveis séricos de adiponectina em gestantes adolescentes
Elaine Cristina Rocha Pádua 
1   Department of Obstetrics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo-SP, Brazil
,
Silvia Daher 
1   Department of Obstetrics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo-SP, Brazil
,
Isa de Pádua Cintra Sampaio 
2   Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo-SP, Brazil
,
Edward Araujo Júnior 
1   Department of Obstetrics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo-SP, Brazil
,
Cristina Falbo Guazzelli 
1   Department of Obstetrics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo-SP, Brazil
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Abstract

Objective To evaluate serum levels of adiponectin in pregnant adolescents between 30 and 36 weeks of gestation.

Method: A prospective cross-sectional study enrolled 67 normal pregnant women between 30 and 36 weeks of gestation and eutrophic (body mass index [BMI]: 18.5–25 kg/m2), of which 36 were adolescents (< 20 years old) and 31 adults (≥ 20 years old). Serum adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA). The t-student or Mann-Whitney tests were used for intergroup comparison.

Results Pregnant adolescents showed significantly higher serum adiponectin concentrations compared with pregnant adults (p = 0.04). No differences were observed in adiponectin levels in younger pregnant adolescents (< 16 years old) compared with older pregnant adolescents (≥ 16 years old). Adiponectin values were divided into 3 subgroups: < 3,000 ng/mL, between 3,000 and 5,000 ng/mL, and > 5,000 ng/mL. Birthweight was significantly higher in women > 5,000 ng/mL when compared with < 3,000 ng/mL in the adolescent group. No association between pregestational adiponectin levels and BMI, gestational weight gain, and gestational age was observed; however, there was a positive relation with birthweight (p = 0.0239).

Conclusion Serum adiponectin values in pregnant adolescents between 30 and 36 weeks of gestation were higher compared with pregnant adults; however, no differences between younger and older pregnant adolescents were observed.

Resumo

Objetivo Avaliar os níveis séricos de adiponectina em gestantes adolescentes entre 30 e 36 semanas de gestação.

Métodos Estudo prospectivo e transversal incluindo 67 gestantes normais entre 30 a 36 semanas e eutróficas (índice de massa corporal [IMC]: 18,5–25 kg/m2), sendo 36 adolescentes (< 20 anos) e 31 adultas (≥ 20 anos). Os níveis séricos de adiponectina foram avaliados por teste imunoenzimático (ELISA, na sigla em inglês). Para a comparação entre os grupos, utilizou-se os testes t-Student ou Mann-Whitney.

Resultados As gestantes adolescentes apresentaram significativamente maiores concentrações séricas de adiponectina do que as adultas (p = 0,04). Não houve diferenças nos níveis de adiponectina quando comparadas as gestantes adolescentes precoces (< 16 anos) às tardias (≥ 16 anos). Os valores de adiponectina foram subdivididos em 3 grupos: < 3.000 ng/mL, entre 3.000 e 5.000 ng/mL e > 5.000 ng/mL. O peso do recém-nascido foi significantemente maior nas mulheres com > 5.000 ng/mL, quando comparadas as com < 3.000 ng/mL no grupo das adolescentes. Não foi observada associação entre os níveis de adiponectina e o IMC pré-gestacional, ganho de peso gestacional e a idade gestacional, porém houve relação positiva com o peso do recém-nascido (p = 0,0239).

Conclusão Os valores séricos de adiponectina em gestantes adolescentes entre 30 e 36 semanas de gestação foram maiores do que os das gestantes adultas; contudo, sem diferenças entre gestantes adolescentes precoces e tardias.

Keywords

adiponectin - adolescence - gestation - inflammation

Palavras-chave

adiponectina - adolescência - gestação - inflamação

Contributors

All authors were involved in the design and interpretation of the analyses, contributed to the writing of the manuscript, read and approved the final manuscript.




Publication History

Received: 24 March 2020

Accepted: 18 February 2021

Article published online:
02 June 2021

© 2021. Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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