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J Am Acad Audiol 2021; 32(06): 379-385
DOI: 10.1055/s-0041-1730365
Research Article

Characteristic Deviations of Auditory Evoked Potentials in Individuals with Autism Spectrum Disorder

Kamakshi V. Gopal
1   Department of Audiology and Speech-Language Pathology, University of North Texas, Denton, Texas
,
Erin C. Schafer
1   Department of Audiology and Speech-Language Pathology, University of North Texas, Denton, Texas
,
Rajesh Nandy
2   Department of Biostatistics and Epidemiology, University of North Texas Health Science Center, Fort Worth, Texas
,
Ashley Brown
1   Department of Audiology and Speech-Language Pathology, University of North Texas, Denton, Texas
,
Joshua Caldwell
1   Department of Audiology and Speech-Language Pathology, University of North Texas, Denton, Texas
,
Bryce Phillips
1   Department of Audiology and Speech-Language Pathology, University of North Texas, Denton, Texas
,
Gabrielle Ballard
1   Department of Audiology and Speech-Language Pathology, University of North Texas, Denton, Texas
› Institutsangaben Funding This study was funded by a research grant from the Texas Higher Education Coordinating Board.
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Abstract

Background Neurological, structural, and behavioral abnormalities are widely reported in individuals with autism spectrum disorder (ASD); yet there are no objective markers to date. We postulated that by using dominant and nondominant ear data, underlying differences in auditory evoked potentials (AEPs) between ASD and control groups can be recognized.

Purpose The primary purpose was to identify if significant differences exist in AEPs recorded from dominant and nondominant ear stimulation in (1) children with ASD and their matched controls, (2) adults with ASD and their matched controls, and (3) a combined child and adult ASD group and control group. The secondary purpose was to explore the association between the significant findings of this study with those obtained in our previous study that evaluated the effects of auditory training on AEPs in individuals with ASD.

Research Design Factorial analysis of variance with interaction was performed.

Study Sample Forty subjects with normal hearing between the ages of 9 and 25 years were included. Eleven children and 9 adults with ASD were age- and gender-matched with neurotypical peers.

Data Collection and Analysis Auditory brainstem responses (ABRs) and auditory late responses (ALRs) were recorded. Adult and child ASD subjects were compared with non-ASD adult and child control subjects, respectively. The combined child and adult ASD group was compared with the combined child and adult control group.

Results No significant differences in ABR latency or amplitude were observed between ASD and control groups. ALR N1 amplitude in the dominant ear was significantly smaller for the ASD adult group compared with their control group. Combined child and adult data showed significantly smaller amplitude for ALR N1 and longer ALR P2 latency in the dominant ear for the ASD group compared with the control group. In our earlier study, the top predictor of behavioral improvement following auditory training was ALR N1 amplitude in the dominant ear. Correspondingly, the ALR N1 amplitude in the dominant ear yielded group differences in the current study.

Conclusions ALR peak N1 amplitude is proposed as the most feasible AEP marker in the evaluation of ASD.

Keywords

autism spectrum disorder - neurotypical peers - auditory brainstem responses - auditory late potentials - AEP marker

Note

Portions of this manuscript have been presented at the American Academy of Audiology conference (2019).


Disclaimer

Any mention of a product, service, or procedure in the Journal of the American Academy of Audiology does not constitute an endorsement of the product, service, or procedure by the American Academy of Audiology.




Publikationsverlauf

Eingereicht: 14. August 2020

Angenommen: 27. Februar 2021

Artikel online veröffentlicht:
03. November 2021

© 2021. American Academy of Audiology. This article is published by Thieme.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

  • References

  • 1 American Psychiatric Association. Diagnostic and Statistical Manual of Mental. 5th edition.. Arlington: American Psychiatric Publishing; 2013
    CrossrefSuche in Google Scholar
  • 2 Elmawgoud SM. The rate of consistency between auditory brainstem response and Gilliam Autism Rating Scale among autistic children. Clin Otolaryngol 2017; 8 (03) 00242
    Suche in Google Scholar
  • 3 Gopal KV, Pierel K. Binaural interaction component in children at risk for central auditory processing disorders. Scand Audiol 1999; 28 (02) 77-84
    CrossrefPubMedSuche in Google Scholar
  • 4 Keith RW. SCAN: A Screening Test for Auditory Processing Disorders. San Antonio, TX: The Psychology Corporation; 1986
    Suche in Google Scholar
  • 5 Modi ME, Sahin M. Translational use of event-related potentials to assess circuit integrity in ASD. Nat Rev Neurol 2017; 13 (03) 160-170
    CrossrefPubMedSuche in Google Scholar
  • 6 Novick B, Vaughan Jr HG, Kurtzberg D, Simson R. An electrophysiologic indication of auditory processing defects in autism. Psychiatry Res 1980; 3 (01) 107-114
    CrossrefPubMedSuche in Google Scholar
  • 7 Pillion JP, Boatman-Reich D, Gordon B. Auditory brainstem pathology in autism spectrum disorder: a review. Cogn Behav Neurol 2018; 31 (02) 53-78
    CrossrefPubMedSuche in Google Scholar
  • 8 Talge NM, Tudor BM, Kileny PR. Click-evoked auditory brainstem responses and autism spectrum disorder: a meta-analytic review. Autism Res 2018; 11 (06) 916-927
    CrossrefPubMedSuche in Google Scholar
  • 9 Yu L, Wang S, Huang D, Wu X, Zhang Y. Role of inter-trial phase coherence in atypical auditory evoked potentials to speech and nonspeech stimuli in children with autism. Clin Neurophysiol 2018; 129 (07) 1374-1382
    CrossrefPubMedSuche in Google Scholar
  • 10 Azouz HG, Kozou H, Khalil M, Abdou RM, Sakr M. The correlation between central auditory processing in autistic children and their language processing abilities. Int J Pediatr Otorhinolaryngol 2014; 78 (12) 2297-2300
    CrossrefPubMedSuche in Google Scholar
  • 11 Miron O, Ari-Even Roth D, Gabis LV. et al. Prolonged auditory brainstem responses in infants with autism. Autism Res 2016; 9 (06) 689-695
    CrossrefPubMedSuche in Google Scholar
  • 12 Roth DA, Muchnik C, Shabtai E, Hildesheimer M, Henkin Y. Evidence for atypical auditory brainstem responses in young children with suspected autism spectrum disorders. Dev Med Child Neurol 2012; 54 (01) 23-29
    CrossrefPubMedSuche in Google Scholar
  • 13 Wong V, Wong SN. Brainstem auditory evoked potential study in children with autistic disorder. J Autism Dev Disord 1991; 21 (03) 329-340
    CrossrefPubMedSuche in Google Scholar
  • 14 Courchesne E, Lincoln AJ, Kilman BA, Galambos R. Event-related brain potential correlates of the processing of novel visual and auditory information in autism. J Autism Dev Disord 1985; 15 (01) 55-76
    CrossrefPubMedSuche in Google Scholar
  • 15 Demopoulos C, Lewine JD. Audiometric profiles in autism spectrum disorders: does subclinical hearing loss impact communication?. Autism Res 2016; 9 (01) 107-120
    CrossrefPubMedSuche in Google Scholar
  • 16 Ververi A, Vargiami E, Papadopoulou V, Tryfonas D, Zafeiriou D. Brainstem auditory evoked potentials in boys with autism: still searching for the hidden truth. Iran J Child Neurol 2015; 9 (02) 21-28
    PubMedSuche in Google Scholar
  • 17 Garreau B, Barthelemy C, Sauvage D, Leddet I, LeLord G. A comparison of autistic syndromes with and without associated neurological problems. J Autism Dev Disord 1984; 14 (01) 105-111
    CrossrefPubMedSuche in Google Scholar
  • 18 Thivierge J, Bédard C, Côté R, Maziade M. Brainstem auditory evoked response and subcortical abnormalities in autism. Am J Psychiatry 1990; 147 (12) 1609-1613
    CrossrefPubMedSuche in Google Scholar
  • 19 Fujikawa-Brooks S, Isenberg AL, Osann K, Spence MA, Gage NM. The effect of rate stress on the auditory brainstem response in autism: a preliminary report. Int J Audiol 2010; 49 (02) 129-140
    CrossrefPubMedSuche in Google Scholar
  • 20 Miron O, Beam AL, Kohane IS. Auditory brainstem response in infants and children with autism spectrum disorder: a meta-analysis of wave V. Autism Res 2018; 11 (02) 355-363
    CrossrefPubMedSuche in Google Scholar
  • 21 Swink S, Stuart A. The effect of gender on the N1-P2 auditory complex while listening and speaking with altered auditory feedback. Brain Lang 2012; 122 (01) 25-33
    CrossrefPubMedSuche in Google Scholar
  • 22 Wagner M, Shafer VL, Haxhari E, Kiprovski K, Behrmann K, Griffiths T. Stability of the cortical sensory waveforms, the P1-N1-P2 complex and T-complex, of auditory evoked potentials. J Speech Lang Hear Res 2017; 60 (07) 2105-2115
    CrossrefPubMedSuche in Google Scholar
  • 23 Jeste SS, Nelson III CA. Event related potentials in the understanding of autism spectrum disorders: an analytical review. J Autism Dev Disord 2009; 39 (03) 495-510
    CrossrefPubMedSuche in Google Scholar
  • 24 Marco EJ, Hinkley LB, Hill SS, Nagarajan SS. Sensory processing in autism: a review of neurophysiologic findings. Pediatr Res 2011; 69 (5 Pt 2): 48R-54R
    CrossrefPubMedSuche in Google Scholar
  • 25 Russo N, Zecker S, Trommer B, Chen J, Kraus N. Effects of background noise on cortical encoding of speech in autism spectrum disorders. J Autism Dev Disord 2009; 39 (08) 1185-1196
    CrossrefPubMedSuche in Google Scholar
  • 26 Donkers FCL, Schipul SE, Baranek GT. et al. Attenuated auditory event-related potentials and associations with atypical sensory response patterns in children with autism. J Autism Dev Disord 2015; 45 (02) 506-523
    CrossrefPubMedSuche in Google Scholar
  • 27 Gopal KV, Schafer EC, Mathews L. et al. Effects of auditory training on electrophysiological measures in individuals with autism spectrum disorder. J Am Acad Audiol 2020; 31 (02) 96-104
    PubMedSuche in Google Scholar
  • 28 Hammill DD, Pearson NA, Weiderholt JL. Comprehensive Test of Nonverbal Intelligence. 2nd edition.. Austin, TX: PRO-ED; 2009
    Suche in Google Scholar
  • 29 Picton TW, Bentin S, Berg P. et al. Guidelines for using human event-related potentials to study cognition: recording standards and publication criteria. Psychophysiology 2000; 37 (02) 127-152
    CrossrefPubMedSuche in Google Scholar
  • 30 Schafer EC, Gopal KV, Mathews L. et al. Effects of auditory training and remote microphone technology on the behavioral performance of children and young adults who have autism spectrum disorder. J Am Acad Audiol 2019; 30 (05) 431-443
    Thieme ConnectPubMedSuche in Google Scholar
  • 31 Moncrieff D. Age- and gender-specific normative information from children assessed with a dichotic words test. J Am Acad Audiol 2015; 26 (07) 632-644
    Thieme ConnectPubMedSuche in Google Scholar
  • 32 Moncrieff DW, Wilson RH. Recognition of randomly presented one-, two-, and three-pair dichotic digits by children and young adults. J Am Acad Audiol 2009; 20 (01) 58-70
    Thieme ConnectPubMedSuche in Google Scholar
  • 33 Bomba MD, Pang EW. Cortical auditory evoked potentials in autism: a review. Int J Psychophysiol 2004; 53 (03) 161-169
    CrossrefPubMedSuche in Google Scholar
  • 34 Kwon S, Kim J, Choe BH, Ko C, Park S. Electrophysiologic assessment of central auditory processing by auditory brainstem responses in children with autism spectrum disorders. J Korean Med Sci 2007; 22 (04) 656-659
    CrossrefPubMedSuche in Google Scholar
  • 35 Magliaro FCL, Scheuer CI, Assumpção Júnior FB, Matas CG. Study of auditory evoked potentials in autism. Pro Fono 2010; 22 (01) 31-36
    CrossrefPubMedSuche in Google Scholar
  • 36 Tharpe AM, Bess FH, Sladen DP, Schissel H, Couch S, Schery T. Auditory characteristics of children with autism. Ear Hear 2006; 27 (04) 430-441
    CrossrefPubMedSuche in Google Scholar
  • 37 Bruneau N, Roux S, Adrien JL, Barthélémy C. Auditory associative cortex dysfunction in children with autism: evidence from late auditory evoked potentials (N1 wave-T complex). Clin Neurophysiol 1999; 110 (11) 1927-1934
    CrossrefPubMedSuche in Google Scholar
  • 38 Sokhadze E, Baruth J, Tasman A. et al. Event-related potential study of novelty processing abnormalities in autism. Appl Psychophysiol Biofeedback 2009; 34 (01) 37-51
    CrossrefPubMedSuche in Google Scholar
  • 39 Oades RD, Walker MK, Geffen LB, Stern LM. Event-related potentials in autistic and healthy children on an auditory choice reaction time task. Int J Psychophysiol 1988; 6 (01) 25-37
    CrossrefPubMedSuche in Google Scholar
  • 40 Andersson S, Posserud MB, Lundervold AJ. Early and late auditory event-related potentials in cognitively high functioning male adolescents with autism spectrum disorder. Res Autism Spectr Disord 2013; 7 (07) 815-823
    CrossrefSuche in Google Scholar
  • 41 Gadea M, Espert R, Chirivella J. Dichotic listening: elimination of the right ear advantage under a dual task procedure. Appl Neuropsychol 1997; 4 (03) 171-175
    CrossrefPubMedSuche in Google Scholar
  • 42 Zatorre RJ, Belin P, Penhune VB. Structure and function of auditory cortex: music and speech. Trends Cogn Sci 2002; 6 (01) 37-46
    CrossrefPubMedSuche in Google Scholar