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DOI: 10.1055/s-0041-1730873
Hemorrhagic Brain Metastases: A Diagnostic Dilemma and Diagnosis of Exclusion
Abstract
Pleomorphic carcinoma is a malignant and aggressive primary lung carcinoma that occurs at a rate of approximately 0.3%. This rarely encountered tumor may present a diagnostic challenge to neuroradiologists and pathologists, as it has propensity to present as hemorrhagic brain metastasis with unknown primary and result in delay in diagnosis that could impact clinical outcome. Herein, we report a unique case in its presentation in a 56-year-old female, having symptomatic brain metastasis prior to the discovery of the pulmonary lesion.
Publication History
Article published online:
13 January 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Schrader B, Barth H, Lang EW. et al. Spontaneous intracranial haematomas caused by neoplasms. Acta Neurochir (Wien) 2000; 142 (09) 979-985
- 2 Shoji F, Maruyama R, Okamoto T. et al. Long-term survival after an aggressive surgical resection and chemotherapy for stage IV pulmonary giant cell carcinoma. World J Surg Oncol 2005; 3: 32
- 3 Travis WD, Brambilla E, Burke AP. et al. WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart. 4th ed. Lyon: IARC Press; 2015
- 4 Rossi G, Cavazza A, Sturm N. et al. Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases. Am J Surg Pathol 2003; 27 (03) 311-324
- 5 Travis WD, Travis LB, Devesa SS. Lung cancer. Cancer 1995; 75 (01) (Suppl 191-202
- 6 Wu DS, Wu CH, Hwang SN. et al. Repeated intracerebral hemorrhage as a presentation of pulmonary giant cell carcinoma with brain metastases. Formosan J Surg 2014; 47: 145-149
- 7 Little JR, Dial B, Bçlanger G, Carpenter S. Brain hemorrhage from intracranial tumor. Stroke 1979; 10 (03) 283-288
- 8 Kondziolka D, Bernstein M, Resch L. et al. Significance of hemorrhage into brain tumors: clinicopathological study. J Neurosurg 1987; 67 (06) 852-857
- 9 Hagihara N, Abe T, Wakamiya T, Sugita Y, Watanabe M, Tabuchi K. A case of brain metastasis from pulmonary giant cell carcinoma. Kurume Med J 2010; 57 (1-2) 39-41
- 10 Koenig MA, Maleszewski J, Winters B. Multiple hemorrhagic strokes from DIC associated with occult large cell carcinoma. Neurocrit Care 2006; 5 (03) 210-212