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Journal of Pediatric Neurology 2022; 20(03): 208-210
DOI: 10.1055/s-0041-1731026
Case Report

Factor XIII Deficiency and Intracranial Bleed: Surgical Management and Prophylaxis with Cryoprecipitate

Sunil V. Furtado 
1   Department of Neurosurgery, Ramaiah Medical College Hospital, Bangalore, India
,
Pranoy Hegde
1   Department of Neurosurgery, Ramaiah Medical College Hospital, Bangalore, India
,
Rasmi Palassery
2   Department of Medical Oncology, Ramaiah Medical College Hospital, Bangalore, India
,
B. P. Karunakara
3   Department of Pediatrics, Ramaiah Medical College Hospital, Bangalore, India
› Author Affiliations Funding None.
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Abstract

Factor XIII (FXIII) deficiency is a rare bleeding disorder with affected patients having high propensity for intracranial hemorrhage. A 12-year-old girl presented with severe headache, limb weakness, and rapidly worsening sensorium over 4 days. Magnetic resonance imaging of the brain and computed tomography (CT) of the head showed intraparenchymal bleed. Patient had normal coagulation profile and abnormal FXIII level. The perioperative management included cryoprecipitate transfusion to bring the FXIII value to 74%. She underwent craniotomy and evacuation of the hematoma. Postoperatively, she received prophylaxis against rebleed with cryoprecipitate. In the absence of FXIII concentrate, correction of FXIII deficiency is possible with cryoprecipitate in emergent situations.

Keywords

brain - craniotomy - cryoprecipitate - factor XIII deficiency - intraparenchymal bleed


Publication History

Received: 27 January 2021

Accepted: 26 March 2021

Article published online:
19 June 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
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