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DOI: 10.1055/s-0041-1731311
The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report)
Funding Not funded.
Abstract
Background Neonatal hemochromatosis (NH) is a rare condition that was the main reason for liver transplantation in infants. With the realization that NH results from the fetal complement-mediated liver injury, intravenous immunoglobulins (IVIG) were successfully introduced for the treatment.
Case Presentation We present two cases of NH from the same family to illustrate the role of antenatal treatment with IVIG in alleviation and possible prevention of this serious morbidity.
Conclusion A prenatal treatment and early postnatal administration of IVIG are effective ways to manage NH that help to reduce the severity of the symptoms, prevent liver failure, and avoid the need for liver transplantation.
Declarations
Ethics approval and consent to participate: no ethics approval required, informed consent from the patient received.
Consent for Publication
Written informed consent was obtained from the parents for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Availability of data and material: available for review.
Authors' Contributions
VMS provided informed consent, collected the data, reviewed the literature, prepared the manuscript preparation, and had direct involvement in patient care.
MR was involved in initial drafting of manuscript, literature review, and had direct involvement in patient care.
EA and AE edited the manuscript and had direct involvement in patient care.
All authors have read and approved the manuscript.
Publikationsverlauf
Eingereicht: 14. März 2020
Angenommen: 21. Mai 2020
Artikel online veröffentlicht:
30. Juni 2021
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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