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DOI: 10.1055/s-0041-1731360
Retroperitoneal, Liver, and Lymph Node Metastasis from Proximal Tibial Osteosarcoma: A Case Report
Artikel in mehreren Sprachen: português | English Financial Support The authors declare that there was no financial support from public, commercial, or non-profit sources.
Abstract
The present study describes the case of a male adult with an osteosarcoma in the proximal tibia, treated with limb salvage with endoprosthesis and chemotherapy. The patient developed an unusual metastatic pattern compromising the liver, bone, and inguinal lymph nodes, without local recurrence in the tibia or pulmonary metastases. Osteosarcoma (OS) is the second most frequent primary bone tumor after multiple myeloma in adults. Frequent sites of metastases in case of disease progression are the lungs and bone. Extrapulmonary metastases are rare. The development of new schemes of chemotherapy have improved life expectancy in osteosarcoma patients but have also altered the usual patterns of metastases, resulting in unusual metastatic locations.
Work carried out at the Hospital Universitario San Ignacio, Bogotá, Colombia.
Publikationsverlauf
Eingereicht: 15. Dezember 2020
Angenommen: 15. Januar 2021
Artikel online veröffentlicht:
13. Oktober 2021
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
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Referências
- 1 Lin JT, Yen CC, Wang WS. et al. Case report: Unusual peritoneal spreading by metastatic osteosarcoma of the tibia. Br J Radiol 2003; 76 (905) 337-338
- 2 Bacci G, Ruggieri P, Picci P. et al. Changing pattern of relapse in osteosarcoma of the extremities treated with adjuvant and neoadjuvant chemotherapy. J Chemother 1995; 7 (03) 230-239
- 3 Oñoro G, Hernández C, Sirvent S. et al. Unusual sites of extrapulmonary metastases of osteosarcoma after several lines of treatment. Pediatr Hematol Oncol 2011; 28 (07) 604-608
- 4 Berhe S, Danzer E, Meyers P, Behr G, LaQuaglia MP, Price AP. Unusual abdominal metastases in osteosarcoma. J Pediatr Surg Case Rep 2018; 28: 13-16
- 5 Giuliano AE, Feig S, Eilber FR. Changing metastatic patterns of osteosarcoma. Cancer 1984; 54 (10) 2160-2164
- 6 Hattori H, Yamamoto K. Lymph node metastasis of osteosarcoma. J Clin Oncol 2012; 30 (33) e345-e349
- 7 Vasiliev NV. Lymph node metastasis of osteosarcomas. [Limfogennoe metastazirovanie sarkom kosti.] Arkh Patol 2016; 78 (04) 58-63
- 8 Jeffree GM, Price CH, Sissons HA. The metastatic patterns of osteosarcoma. Br J Cancer 1975; 32 (01) 87-107
- 9 Yanagawa T, Saito K, Takagishi K. Risk factors for lymphatic metastasis of malignant bone and soft-tissue tumors: a retrospective cohort study of 242 patients. Medicine (Baltimore) 2014; 93 (27) e225
- 10 Lev-Chelouche D, Nakache R, Soffer D, Merimsky O, Klausner MJ, Gutman M. Metastases to the retroperitoneum in patients with extremity soft tissue sarcoma: an unusual metastatic pattern. Cancer 2000; 88 (02) 364-368