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Homœopathic Links 2021; 34(S 01): 037-045
DOI: 10.1055/s-0041-1731849
Original Article

Homoeopathic Management of Breast Fibroadenoma—An Open Label, Single Arm, Observational Trial

Purnima Shukla
1   Homeopathic Consultant, C-4, Shivalik, Malviya Nagar, New Delhi
,
Purak Misra
2   Department of Surgery, ESIC Medical College, Faridabad, Haryana, India
,
Rajiv Kumar Misra
3   Department of Pathology, B.R.D Medical College, Gorakhpur, Uttar Pradesh, India
,
Rishabh Kumar Jain
4   Department of Radiodiagnosis, B.R.D Medical College, Gorakhpur, Uttar Pradesh, India
,
Rakesh Shukla
5   Department of Pharmacology, Central Drug Research Institute, Lucknow, Uttar Pradesh, India
,
R.K Manchanda
6   Central Council for Research in Homeopathy, New Delhi, India
,
Anil Khurana
6   Central Council for Research in Homeopathy, New Delhi, India
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Homoeopathic Management of Breast Fibroadenoma—An Open Label, Single Arm, Observational TrialHomœopathic Links 2020; 33(02): 090-098
DOI: 10.1055/s-0040-1712479

Abstract

Achtergrond Fibroadenoom van de borst is de meest voorkomende kwaal bij vrouwen met een aanzienlijk risico op overlijden. Uit de beschikbare literatuur blijkt dat borsttumoren verdwijnen door homeopathische behandeling. De huidige studie evalueerde de rol van homeopathische behandeling op borstfibroadenoma met behulp van ‘Triple assessment criteria’ (dubbel blind) en onderzoekt of homeopathische geneesmiddelen therapeutisch effect teweeg brengen door het veranderen van de oestrogeen en progesteron receptor (ER/PR) status op tumorweefsel.

Materialen en Methoden Een open-label, prospectieve, single-arm, observationele studie werd uitgevoerd bij 64 vrouwelijke patiënten met fibroadenoom van de borst. Er werden drievoudige beoordelingscriteria gebruikt om de doeltreffendheid van de homeopathische behandeling van borstfibroadenomen te onderzoeken. Geïndividualiseerde homeopathische geneesmiddelen werden voorgeschreven. De meetresultaten vertoonden veranderingen in het klinisch beeld en het aantal en de omvang van de knobbels door middel van ultrasoonmammografie. ER/PR studie werd uitgevoerd door immunohistochemie met gebruik van quick score analyse.

Resultaten Bij 23 gevallen (35,93%) van fibroadenomen was er na de behandeling geen knobbel meer meetbaar. Gedeeltelijke verbetering werd waargenomen in 22 gevallen (34,37%) met significante vermindering van de gemiddelde grootte (p < 0,001). Ook werd een significante vermindering van het aantal laesies gezien bij fibroadenomen (p < 0,05). Conium maculatum en Phytolacca decandra bleken de meest bruikbare remedies te zijn. De quick score waarde van ER na behandeling toonde significante vermindering (Z ¼ 4.910).

Conclusie De studie toont aan dat de therapeutische effecten van toediening van geïndividualiseerde homeopathische geneesmiddelen een belangrijke rol spelen bij de behandeling van fibroadenomen van de borst. De resultaten van ER/PR laten een significante vermindering van ER zien, wat suggereert dat homeopathische geneesmiddelen een remmend effect hebben op ER.

Keywords

fine-needle aspiration cytology (FNAC) - ultrasonomammography - oestrogen receptor (ER) - progesterone receptor (PR) - homoeopathy - breast fibroadenoma

Author Contribution

PS: Concept, literature search, clinical study, data acquisition, data interpretation and preparation of the article; PM: About the present modern medicine intervention, drafting the paper; RK Misra: Expert opinion regarding pathological investigation; RKJ: Ultrasonological examination and expert opinion; RS: Research advice; RK Manchanda and AK: Technical opinion regarding research. All the authors reviewed and approved the final paper.


Financial Support

The project was funded under the Extra-Mural Research Scheme of Ministry of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy, Government of India (vide letter no F. No - 23 - 111/2009 - 10/CCRH/Tech/EMR/8758 dated 7th September 2009). Technical and administrative support was provided by the Central Council for Research in Homoeopathy.


The article was published originally in Homoeopathic Links 2020;33(2):90-98 with DOI: 10.1055/s-0040-1712479.




Publikationsverlauf

Artikel online veröffentlicht:
11. November 2021

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