CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2007; 28(02): 7-15
DOI: 10.1055/s-0041-1733211
Original Article

A Randomized, Prospective Open Labeled Study of Oral Amoxicillin-clavulanate and Levofloxacin with Intravenous Ceftriaxone and Amikacin in Chemotherapy Induced Low Risk Febrile Neutropenia

Joseph Dominic
Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
,
Lalit Kumar
Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
,
Vinod Kochupillai
Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
,
Vinod Raina
Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
,
Atul Sharma
Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
,
Sameer Bakhshi
Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
,
Tulika Seth
Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
,
Arti Kapil
Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
,
V Sreenivas
Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India
› Author Affiliations


Publication History

Article published online:
07 March 2022

© 2007. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Rubin M, Hathorn JW, Pizzo PA. Controversies in the management of febrile neutropenic cancer patients. Cancer Invest 1988;6-167.
  • 2 Talcott JA, Finberg R, Mayer RJ, Goldman L. The medical course of cancer patients with fever and neutropenia. Clinical identification of a low-risk subgroup at presentation. Arch Intern Med 1988;148-2561
  • 3 Talcott JA, Siegel RD, Finberg R, Goldman L. Risk assessment in cancer patients with fever and neutropenia: a prospective, two-center validation of a prediction rule. J Clin Oncol 1992;10-316.
  • 4 Klasterky J, Paesman M, Rubenstein EB et al . The multinational association for supportive care in cancer risk index: a multinational scoring system for identifying low risk febrile neutropenia . J.Clin Oncology 2000;18 :3038-51.
  • 5 Rolston KVI. New trends in patient management: riskbased therapy for febrile patients with neutropenia. Clin Infect Dis 1999;29:515-21.
  • 6 Aquino VM, Tkaczewski I, Buchanan GR. Early discharge of low-risk febrile neutropenic children and adolescents with cancer. Clin infect Dis 1997;25:74-8.
  • 7 Klaasseen RJ, Goodman R, Pham BA, Doyle JJ. Low-risk prediction rule for pediatric oncology patients presenting with fever and neutropenia. J Clin Oncol 2000;18:1012-9.
  • 8 Lucas KG ,Brown AE, Armstrong D et al. The identification of febrile neutropenic children with low risk for bacteremia and complications of sepsis. Cancer 1996;77:791-798
  • 9 Kern WV, Cometta A, DeBock R, et al. Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. N Engl J Med 1999;341:312-8
  • 10 Freifeld A, Marchigiani D, Walsh T, et al. A double-blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy. N Engl J Med 1999;341:305- 11.
  • 11 Rackoff WR,Gonin R, Robinson C et al . Predicting the risk of bacteremia in children with fever and neutropenia. J Clin Oncology 1996;14:919-924.
  • 12 Talcott JA, Whalen A, Clark J, Rieker PP, Finberg R. Home antibiotic therapy for low-risk cancer patients with fever and neutropenia: a pilot study of 30 patients based on a validated prediction rule. J Clin Oncol 1994;12- 107.
  • 13 Rubenstein EB, Rolston K, Benjamin RS, et al. Outpatient treatment of febrile episodes in low-risk neutropenic patients with cancer. Cancer 1993;71-3640.
  • 14 Malik IA, Abbas Z, Karim M. Randomised comparison of oral ofloxacin alone with combination of parenteral antibiotics in neutropenic febrile patients [published erratum appears in Lancet 1992; 340(8811):128]. Lancet 1992;339-1092.
  • 15 Malik IA, Khan WA, Karim M, Aziz Z, Khan MA. Feasibility of outpatient management of fever in cancer patients with low-risk neutropenia: results of a prospective randomized trial Am J Med 1995;98-224.
  • 16 Liat Vidal, Mical Paul, Istik Ben dor,Karla Soares- Weiser,Leonard Leibovici. Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients: a systematic review and meta-analysis of randomized trials. J Antimicrobial Chemotherapy 2004;54-29.
  • 17 Fu KP, Lafredo SC, Foleno B, et al. In vitro and in vivo antibacterial activities of levofloxacin, an optically active ofloxacin. Antimicrob Agents Chemother 1992;36- 860.
  • 18 Feld R, Paesmans M, Freifeld AG, et al. Methodology for clinical trails involving patients with cancer who have febrile neutropenia: updated guidelnies of the Immuno-compromised Host Society / Multinational Association for Supportive Care in Cancer with emphasis on outpatients studies. Clin Infectious Dis 2002;35:1463-8.
  • 19 Velasco E, Costa MA, Martins CA, et al. Randomized trial comparing oral ciprofloxacin plus penicillin V with amikacin plus carbenicillin or ceftazidime for empirical treatment of febrile neuropenic cancer patients. Am J Clin Oncol Cancer Clin Trials 1995;18:429-35.
  • 20 Hidalgo M, Homedo J, Lumbreras C, et al. Out patient therapy with oral ofloxacin for patients with low risk Neutropenia and fever a prospective, randomized clinical trial. Cancer 1999;85:213
  • 21 Innes HE, Smith DB, O’ Reilly SM, et al. Oral antibiotics with early hospital discharge compared with in patient intravenous antibiotics for low-risk febrile Neutropenia in patients with cancer: a prospective randomized controlled single center study. Br J Cancer 2003;89:43-9.
  • 22 Elting LS Rubenstein EB Rolston K et al. Time to clinical response : an outcome of antibiotic therapy of febrile neutropenia with implications for quality and cost of care. J Clin Oncol 2000;18:3699-3706.