Download PDF
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2007; 28(03): 46-47
DOI: 10.1055/s-0041-1733232
Letter to the Editor

A Child with Acute Lymphoblastic Leukemia (ALL) Presenting with Symptomatic Hypercalcemia and Multiple Osteolytic Lesions

Gull Bhat
Department of Medical Oncology, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), India
› Author Affiliations
› Further Information
Also available at
  PDF Download Permissions and Reprints


Publication History

Article published online:
07 March 2022

© 2007. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Nies BA, Kundal DW, Thomas LB et. al. Leucopenia, bone pain, bone necrosis in patients with acute leukemia. A clinicopathological complex. Ann Intern Med 1965;62:698,92.
  • 2 Osteopenia or lytic lesions may be seen in upto 50% of patients in ALL Randy B, Hanna k in Leukemia in Washington Manual of Oncology, 2002 Page 253;
  • 3 Hibi S. Funaki H, Oschiai-Kanai et. al. Acutelymphoblastic leukemia in adolescence with multiple osteolytic lesions and hypercacemia mediated by lymphoblast producing parathyroid hormone related peptide: a case report and review of literature Pediatr Blood Cancer 2005;45[3]333-9.
  • 4 Shimon Dan H, Nagoya J, Negates Y, et. al. Acute lymphocyte leukemia in adolescence with multiple osteolytic lesions and hypercalcemia mediated by lymphoblast-producing parathyroid hormone-related peptide: a case report and review of the literature. Pediatr Blood Cancer, 2005;45(3),333-9.
  • 5 Paola B, Antonio R, Marco P, Riccardo R, Giancario p, Antonio C.A case of acute lymphblastic leukemia prsesenting as severe hypercalcamia. Pediatric Hematology and Oncology, 2004;Vol. 21,(6)475-479.
  • 6 Shinjiro Todo, Shinsaku Imashuku, Hiroshi Inoda,et al. Hypercalcemia in a Case of Childhood Acute Lymphoblastic Leukemia, Japanese J. Clin Oncol 1987;17:357-362.
  • 7 Antunovic P, Marisavljevic D, Kraguljac N, Jelusic V. Severe hypercalcaemia and extensive osteolytic lesions in an adult patient with T cell acute lymphoblastic leukaemia. Med Oncol, 1998;15(1):58- 60.
  • 8 Yamamoto Y, Ishii K, Nomura S, Fukuhara S. Adult T-cell leukemia /lymphoma of bone with multiple pathological fractures] Rinsho Ketsueki. 2004;45(3):247-9.
  • 9 Anzai S, Takayasu S, Fujiwara S, Tateyama M, Taira H, Takashita M. Elevation of IL-6 in ATL patient with a pathological fracture. J Dermatol. 2002;29(10):644.
  • 10 Miyamura T, Taguchi F, Ishikura H, et al. Production of parathyroid hormone-related peptide in a patient with acute lymphocytic leukemia with extensive osteolytic lesions and hypercalcemia. Am J Hematol. 1995;50(2):150-1.
  • 11 Lankisch P, Kramm CM, Hermsen D, Wessalowski R. Hypercalcemia with nephrocalcinosis and impaired renal function due to increased Parathyroid hormone secretion at onset of childhood acute lymphoblastic leukemia. Leuk Lymphoma. 2004;45(8):1695-7.
  • 12 Shanks D, Linke R, Saxon B. Bones groans and blasts. J Paediatr Child Health. 2001;37(5):504-6.
  • 13 Muller JH, Valdez R, Hayes C, and Kaminski MS, Acute megakaryocytic leukemia presenting as hypercalcemia and osteolytic lesions.Eur J Haematology. 2002;68(6):392-6.
  • 14 T Inukai, K Hirose, T Inaba et al, Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19 Leukemia 2007;21,288–296.