Surgical treatment of liver metastases from non-colorectal non-neuroendocrine carcinomas

Introduction In the literature, results after surgical treatment of non-colorectal non-neuroendocrine liver metastases (NCNNLM) are reported that are often inferior to those from colo-rectal liver metastases. The selection of patients with favorable tumor biology is currently still a matter of discussion.

Materials and methods The retrospective data analysis was based on data that were collected for the multi-center study „Role of surgical treatment for non-colorectal liver metastases” in county Thuringia.

Results For the study, 637 patients were included from 1995 to 2018. Five- and 10-year survival of R0 resected patients were 33 and 19%, respectively. In the multi-variate analysis of the entire group, sex, timing, disease-free interval, number of metastases, R classification as well as lymph node status of the primary lesion showed an independent statistical influence on the 5-yearssurvival. In the group of R0 resected patients, disease-free interval, number of metastases and lymph node status of the primary lesion influenced the 5-year survival in the multi-variate analysis. In kidney malignancies, R classification, timing and number of liver metastases were statistically significant in the multi-variate analysis of the 5-year survival, in mamma carcinomas only the R classification.

Conclusion The Adam score identifies some risk factors which influence prognosis in most but not in all tumor entities. For kidney cancer and breast cancer it can be simplified.

Publication History

Article published online:
07 September 2021