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CC BY 4.0 · Rev Bras Ortop (Sao Paulo) 2024; 59(03): e471-e474
DOI: 10.1055/s-0041-1733797
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Effects of Adipose-derived Stem Cells in the Treatment of Knee Osteoarthritis: A Case Report in Brazil's Unified Health System

Article in several languages: português | English
Laynna de Carvalho Schweich-Adami 
1   Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica – CeTroGen, Hospital Universitário Maria Aparecida Pedrossian – HUMAP/EBSERH, Universidade Federal de Mato Grosso do Sul – UFMS, Campo Grande, MS, Brazil
2   Programa de Pós-Graduação em Saúde e Desenvolvimento da Região Centro-Oeste, Faculdade de Medicina Dr. Hélio Mandetta – Famed, Universidade Federal de Mato Grosso do Sul – UFMS, Campo Grande MS, Brazil
,
Roberto Antoniolli da Silva 
3   Ambulatório de Ortopedia e Traumatologia, Hospital Universitário Maria Aparecida Pedrossian – HUMAP/EBSERH, Universidade Federal de Mato Grosso do Sul – UFMS, Campo Grande, MS, Brazil
,
Adrivanio Baranoski 
1   Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica – CeTroGen, Hospital Universitário Maria Aparecida Pedrossian – HUMAP/EBSERH, Universidade Federal de Mato Grosso do Sul – UFMS, Campo Grande, MS, Brazil
,
Candida Aparecida Leite Kassuya 
4   Faculdade de Ciências da Saúde – FCS, Universidade Federal da Grande Dourados – UFGD, Dourados, MS, Brasil
,
Andréia Conceição Milan Brochado Antoniolli-Silva 
1   Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica – CeTroGen, Hospital Universitário Maria Aparecida Pedrossian – HUMAP/EBSERH, Universidade Federal de Mato Grosso do Sul – UFMS, Campo Grande, MS, Brazil
2   Programa de Pós-Graduação em Saúde e Desenvolvimento da Região Centro-Oeste, Faculdade de Medicina Dr. Hélio Mandetta – Famed, Universidade Federal de Mato Grosso do Sul – UFMS, Campo Grande MS, Brazil
,
Rodrigo Juliano Oliveira 
1   Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica – CeTroGen, Hospital Universitário Maria Aparecida Pedrossian – HUMAP/EBSERH, Universidade Federal de Mato Grosso do Sul – UFMS, Campo Grande, MS, Brazil
2   Programa de Pós-Graduação em Saúde e Desenvolvimento da Região Centro-Oeste, Faculdade de Medicina Dr. Hélio Mandetta – Famed, Universidade Federal de Mato Grosso do Sul – UFMS, Campo Grande MS, Brazil
5   Programa de Pós-Graduação em Genética e Biologia Molecular, Centro de Ciências Biológicas – CCB, Universidade Estadual de Londrina – UEL, Londrina, PR, Brasil
› Author Affiliations Financial Support The authors would like to thank Dr. Tatyanne Ferreira da Silva for the liposuction procedure, as well as FUNDECT, CNPq and CAPES for the financial support.
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Abstract

Osteoarthritis (OA) can incapacitate the individual to perform their activities of daily living due to pain. This is an important public health issue that worsens worldwide and in Brazil, since the population goes through an aging process, and has caused increased public spending on the monitoring and maintenance of treatments that can last for years and still not be resolutive. Thus, the search for innovative and effective therapies that can reduce costs becomes necessary. In this context, the present study reports the first application of cell therapy with adipose-derived stem cells in the treatment of cases of OA that are refractory to the conservative treatment, performed in the Brazilian Unified Health System (Sistema Único de Saúde, SUS). The evaluation was performed with the application of the Visual Analog Scale (VAS), the Short Form Health Survey (SF-36) and the Western Ontario and McMaster Universities (WOMAC), specifics for OA evaluation, and also an analysis of the synovial fluid (inflammatory cytokines). The cell therapy improved the scores on the WOMAC, SF-36 and EVA, and reduced the inflammatory process. We observed a decrease of 0.73x in the TNF, of 0,71x in IL-1b, of 0,68x in IL-8, and of 0,70x in IL-10. For IL-6, an increase of 1,48x was observed. Therefore, this cell therapy can be considered promising in aiding the management of this disease, since it improved the patient's pain, decrease inflammatory markers, and enabled the return to activities of daily living, which resulted in an improvement in their quality of life.

Keywords

cell therapy - inflammation - joint pain - orthopedics - regenerative medicine - Unified Health System


Publication History

Received: 29 October 2020

Accepted: 11 February 2021

Article published online:
01 October 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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