Subscribe to RSS
DOI: 10.1055/s-0041-1733985
School-Age Outcome of Fetuses with Isolated Complete Septum Pellucidum Agenesis at Prenatal Magnetic Resonance Imaging
Funding Statement No funding was received for the present work.![](https://www.thieme-connect.de/media/neuropediatrics/202201/lookinside/thumbnails/10-1055-s-0041-1733985_202788oa-1.jpg)
Abstract
Objective To the best of our knowledge, there have not been studies to address the issue of long-term follow-up of patients with prenatal diagnosis of isolated complete septum pellucidum agenesis (SPA). The aim of this study was to acquire information about the school-age outcome of such patients as a resource for counseling parents receiving this prenatal finding.
Methods From a large fetal magnetic resonance (MR) database, we selected only those cases with isolated complete SPA as confirmed by two senior pediatric neuroradiologists in consensus; we then gathered information from the parents of those children who had reached the school age.
Results None among the 12 cases (mean age at follow-up: 8.7 years, range: 6–13 year) of the resulting final cohort presented visual or stature deficits; only one required special teaching assistance in school. All other 11 children resulted without any notable academic issue.
Conclusion Our report may provide information of practical value about the school-age outcome of fetuses detected by prenatal MR imaging to carry isolated complete SPA.
Publication History
Received: 16 November 2020
Accepted: 04 January 2021
Article published online:
17 August 2021
© 2021. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
References
- 1 Lepinard C, Coutant R, Boussion F. et al. Prenatal diagnosis of absence of the septum pellucidum associated with septo-optic dysplasia. Ultrasound Obstet Gynecol 2005; 25 (01) 73-75
- 2 Damaj L, Bruneau B, Ferry M. et al. Pediatric outcome of children with the prenatal diagnosis of isolated septal agenesis. Prenat Diagn 2010; 30 (12,13): 1143-1150
- 3 Vawter-Lee MM, Wasserman H, Thomas CW. et al. Outcome of isolated absent septum pellucidum diagnosed by fetal magnetic resonance imaging (MRI) scan. J Child Neurol 2018; 33 (11) 693-699
- 4 Belhocine O, André C, Kalifa G, Adamsbaum C. Does asymptomatic septal agenesis exist? A review of 34 cases. Pediatr Radiol 2005; 35 (04) 410-418
- 5 Griffiths PD, Jarvis D. Analysis of 270 fetuses with non-visualisation of the cavum septi pellucidi and vergae on in-utero magnetic resonance imaging. Ultrasound Obstet Gynecol 2020; 56 (05) 732-739
- 6 Li Y, Sansgiri RK, Estroff JA. et al. Outcome of fetuses with cerebral ventriculomegaly and septum pellucidum leaflet abnormalities. AJR Am J Roentgenol 2011; 196 (01) W83-W92
- 7 Righini A, Parazzini C, Doneda C, Arrigoni F, Triulzi F. Prenatal MR imaging of the normal pituitary stalk. AJNR Am J Neuroradiol 2009; 30 (05) 1014-1016
- 8 Dangouloff-Ros V, Roux CJ, Boulouis G. et al. Incidental brain MRI findings in children: a systematic review and meta-analysis. AJNR Am J Neuroradiol 2019; 40 (11) 1818-1823
- 9 Prayer D, Malinger G, Brugger PC. et al. ISUOG Practice Guidelines: performance of fetal magnetic resonance imaging. Ultrasound Obstet Gynecol 2017; 49 (05) 671-680
- 10 Righini A, Parazzini C, Doneda C. et al. Early formative stage of human focal cortical gyration anomalies: fetal MRI. AJR Am J Roentgenol 2012; 198 (02) 439-447