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CC BY 4.0 · Rev Bras Ginecol Obstet 2021; 43(08): 616-621
DOI: 10.1055/s-0041-1733998
Original Article | Artigo Original
Oncology

Hereditary Breast and Ovarian Cancer Screening Syndrome Profile in Women Diagnosed with Breast Cancer from Paraná State Southwest

Perfil do rastreamento da síndrome hereditária de câncer de mama e ovário em mulheres diagnosticadas com câncer de mama na região sudoeste do Paraná
Juliana Batista de Moura 
1   Laboratory of Tumor Biology, Universidade do Estado do Paraná, Francisco Beltrão, PR, Brazil
,
Carla Camila Ghedin 
1   Laboratory of Tumor Biology, Universidade do Estado do Paraná, Francisco Beltrão, PR, Brazil
,
Érika Tomie Takakura 
1   Laboratory of Tumor Biology, Universidade do Estado do Paraná, Francisco Beltrão, PR, Brazil
,
Thalita Basso Scandolara 
1   Laboratory of Tumor Biology, Universidade do Estado do Paraná, Francisco Beltrão, PR, Brazil
2   Department of Genetics, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
,
Daniel Rech 
3   Center of Health Sciences, Francisco Beltrão Cancer Hospital, Francisco Beltrão, PR, Brazil
,
Carolina Panis 
1   Laboratory of Tumor Biology, Universidade do Estado do Paraná, Francisco Beltrão, PR, Brazil
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Abstract

Objective This study evaluated the risk of the hereditary breast and ovarian cancer (HBOC) syndrome in patients with breast cancer by using the Family History Screening 7 (FHS-7) tool, a validated low-cost questionnaire with high sensitivity able to screen the HBOC risk in the population.

Methods Women diagnosed with breast cancer (n = 101) assisted by the Unified Health System at the 8th Regional Health Municipal Office of the state of Paraná answered the FHS-7, and the results were analyzed using IBM SPSS Statistics for Windows, Version 25.0. software (IBM Corp., Armonk, NY, USA).

Results The risk of HBOC was 19.80% (n = 20). Patients at risk exhibited aggressive tumor characteristics, such as high-grade tumors (30%), presence of angiolymphatic emboli (35%), and premenopausal at diagnosis (50%). Significant associations between the prevalence of high-grade tumors were observed in women younger than 50 years at diagnosis with HBOC (p = 0.003).

Conclusion Our findings suggest a possible family inheritance associated with worse clinical features in women with breast cancer in this population, indicating that HBOC investigation can be initially performed with low-cost instruments such as FHS-7.

Resumo

Objetivo Este estudo avaliou o risco da síndrome hereditária de câncer de mama e ovário (HBOC, na sigla em inglês) em pacientes com câncer de mama utilizando a ferramenta Familial History Screening 7 (FHS-7), um questionário validado de baixo custo e com alta sensibilidade capaz de rastrear o risco de HBOC na população.

Métodos Mulheres diagnosticadas com câncer de mama (n = 101) assistidas pelo Sistema Único de Saúde da 8ª Regional de Saúde do estado do Paraná responderam ao questionário FHS-7, e os resultados foram analisados pelo software IBM SPSS for Windows, Version 25.0. (IBM Corp., Armonk, NY, EUA).

Resultados A ocorrência do risco de HBOC foi de 19,80% (n = 20). Pacientes em risco exibiram características agressivas do tumor como tumores de alto grau (30%), presença de êmbolos angiolinfáticos (35%) e pré-menopausa ao diagnóstico (50%). Associações significantes foram observadas entre a prevalência de tumores de alto grau e diagnóstico abaixo de 50 anos no grupo HBOC (p = 0.003).

Conclusão Nossos achados sugerem uma possível herança familiar associada a piores características clínicas em mulheres com câncer de mama nessa população, indicando que a investigação de HBOC pode ser realizada, inicialmente, com instrumentos de baixo custo, como o FHS-7.

Keywords

breast cancer - hereditary breast and ovary cancer syndrome - cancer screening - public health

Palavras-chave

câncer de mama - síndrome hereditária de câncer de mama e ovário - rastreamento de câncer - saúde pública

Contributors

C. P. and D. R. conceived and planned the study. The other authors performed the interviews and interpretation of the results. All authors wrote the manuscript and provided critical feedback.




Publication History

Received: 07 July 2020

Accepted: 27 May 2021

Article published online:
21 September 2021

© 2021. Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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