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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2021; 31(03): 551-559
DOI: 10.1055/s-0041-1734411
Original Article

Imaging Spectrum of Lobular Carcinoma In Situ and Correlation with Pathology Findings

Pradipta C Hande
1   Department of Radiology and Imaging, Breach Candy Hospital Trust, Bhulabhai Desai Road, Mumbai, Maharashtra, India
,
Sarabjeet Kaur Arneja
2   Department of Surgical Pathology and Cytology, Breach Candy Hospital Trust, Bhulabhai Desai Road, Mumbai, Maharashtra, India
,
Sabita S Desai
3   Department of Radiology, Breach Candy Hospital Trust, Bhulabhai Desai Road, Mumbai, Maharashtra, India
› Author Affiliations Financial Support and Sponsorship Nil.
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Abstract

Background Lobular carcinoma in situ (LCIS) is a noninvasive neoplasm that is known to have an increased relative risk for developing subsequent invasive breast carcinoma. Pure LCIS is usually an incidental finding on histopathological examination (HPE) of tissue samples. However, in the recent years, there has been an increasing trend seen in the diagnosis of LCIS.

Purpose This article aims to bring out the spectrum of appearances on breast imaging in confirmed cases of pure LCIS on HPE and immunohistochemical.

Materials and Methods Cases that were confirmed as pure LCIS on HPE from core or excision biopsy were retrospectively analyzed for abnormalities on breast imaging. Digital breast tomosynthesis mammography was performed with high-resolution ultrasound with elastography for all cases. Magnetic resonance imaging (MRI) was performed in cases wherever indicated, with dynamic postcontrast imaging after injecting intravenous gadolinium.

Conclusion LCIS is recognized as an intermediate risk factor for the development of breast cancer. Pure LCIS has varied histology and imaging patterns on mammography, high-resolution ultrasound, and MRI. It is important to recognize the imaging appearances of these lesions to enable the radiologist to detect LCIS early for proper management.

Keywords

architectural distortion - digital breast tomosynthesis - hook-wire localization - immunohistochemistry - lobular carcinoma in situ - microcalcifications


Publication History

Article published online:
23 August 2021

© 2021. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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