Abstract
Background Lobular carcinoma in situ (LCIS) is a noninvasive neoplasm that is known to have
an increased relative risk for developing subsequent invasive breast carcinoma. Pure
LCIS is usually an incidental finding on histopathological examination (HPE) of tissue
samples. However, in the recent years, there has been an increasing trend seen in
the diagnosis of LCIS.
Purpose This article aims to bring out the spectrum of appearances on breast imaging in confirmed
cases of pure LCIS on HPE and immunohistochemical.
Materials and Methods Cases that were confirmed as pure LCIS on HPE from core or excision biopsy were retrospectively
analyzed for abnormalities on breast imaging. Digital breast tomosynthesis mammography
was performed with high-resolution ultrasound with elastography for all cases. Magnetic
resonance imaging (MRI) was performed in cases wherever indicated, with dynamic postcontrast
imaging after injecting intravenous gadolinium.
Conclusion LCIS is recognized as an intermediate risk factor for the development of breast cancer.
Pure LCIS has varied histology and imaging patterns on mammography, high-resolution
ultrasound, and MRI. It is important to recognize the imaging appearances of these
lesions to enable the radiologist to detect LCIS early for proper management.
Keywords
architectural distortion - digital breast tomosynthesis - hook-wire localization -
immunohistochemistry - lobular carcinoma in situ - microcalcifications
