Adipositas - Ursachen, Folgeerkrankungen, Therapie 2021; 15(03): 159-160
DOI: 10.1055/s-0041-1735694
Abstracts
Wiesbaden: Adipositas-Kongress 2021

35 Changes in epigenetic regulation are associated with metabolic disease and inflammation in pediatric obesity

Julia Lischka
1   Clinical Division of Pediatric Pulmonology, Allergology and Endocrinology, Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Vienna, Österreich
,
Andrea Schanzer
1   Clinical Division of Pediatric Pulmonology, Allergology and Endocrinology, Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Vienna, Österreich
,
Chike Item
1   Clinical Division of Pediatric Pulmonology, Allergology and Endocrinology, Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Vienna, Österreich
,
Azadeh Hojreh
2   Clinical Division of Pediatric Pulmonology, Allergology and Endocrinology, Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Österreich
,
Ahmed BA Ssalamah
2   Clinical Division of Pediatric Pulmonology, Allergology and Endocrinology, Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Österreich
,
Susanne Greber-Platzer
1   Clinical Division of Pediatric Pulmonology, Allergology and Endocrinology, Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Vienna, Österreich
,
Maximilian Zeyda
1   Clinical Division of Pediatric Pulmonology, Allergology and Endocrinology, Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Vienna, Österreich
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Background

Chronic low-grade inflammation plays a pivotal role in dysregulation of central pathways involved in lipid and glucose metabolism in obesity leading to metabolic disease. MicroRNAs (miRNAs) are known to fine-tune gene expression upstream from known regulators of metabolic homeostasis. We aimed to assess the relationship of circulating miRNAs with inflammatory modulators and metabolic disorders in pediatric obesity.



Publication History

Article published online:
24 September 2021

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