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CC BY 4.0 · Journal of Child Science 2021; 11(01): e262-e264
DOI: 10.1055/s-0041-1736157
Case Report

Extended Cranial Ultrasound Views in Infants with Acute Brain Stem/Infratentorial Lesions: Diagnosis of a Progressive Midline Glioma in a 6-Week-Old Infant

Matthias Lange 
1   Department of Neonatology, Pediatric Intensive Care and Cardiology, University of Oldenburg, Oldenburg, Germany
,
Bernd Mitzlaff
1   Department of Neonatology, Pediatric Intensive Care and Cardiology, University of Oldenburg, Oldenburg, Germany
,
Florian Beske
1   Department of Neonatology, Pediatric Intensive Care and Cardiology, University of Oldenburg, Oldenburg, Germany
,
Holger Koester
1   Department of Neonatology, Pediatric Intensive Care and Cardiology, University of Oldenburg, Oldenburg, Germany
,
Wiebke Aumann
2   Department of Neurosurgery, Evangelisches Krankenhaus Oldenburg, Oldenburg, Germany
,
Johannes Woitzik
2   Department of Neurosurgery, Evangelisches Krankenhaus Oldenburg, Oldenburg, Germany
,
Hermann L. Mueller
1   Department of Neonatology, Pediatric Intensive Care and Cardiology, University of Oldenburg, Oldenburg, Germany
,
Axel Heep
1   Department of Neonatology, Pediatric Intensive Care and Cardiology, University of Oldenburg, Oldenburg, Germany
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Abstract

Central nervous system (CNS) tumors are the most common solid tumors in children and adolescents. However, in neonates and children aged younger than a year, they are very rare. Clinical presentation in neonates is often subtle and nonspecific. When neurological symptoms are apparent at this age, cranial ultrasound (CUS) is often done as the initial evaluation, with a standard approach through the anterior fontanel (AF), followed by further imaging, such as magnetic resonance imaging (MRI), if necessary. We report the first neonatal case of a rapidly progressive diffuse midline glioma positive for histone H3 K27M mutation (World Health Organization [WHO] grade IV) in which using extended (transmastoid) CUS studies through the mastoid fontanelle (MF) in the second month of life defined the lesion in the brainstem.

Keywords

cranial ultrasound - fontanella mastoidea - brainstem glioma


Publication History

Received: 25 December 2020

Accepted: 08 August 2021

Article published online:
28 September 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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