Progress in the Synthesis of Heterocyclic Compounds Catalyzed by Lipases

Xiao-Long Ma; Yu-Han Wang; Jin-Hua Shen; Yi Hu

doi:10.1055/s-0041-1736233

Pharmaceutical Fronts, Table of Contents

CC BY 4.0 · Pharmaceutical Fronts 2021; 03(03): e87-e97
DOI: 10.1055/s-0041-1736233

Review Article

Progress in the Synthesis of Heterocyclic Compounds Catalyzed by Lipases

Xiao-Long Ma

¹State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, People's Republic of China

,

Yu-Han Wang

¹State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, People's Republic of China

,

Jin-Hua Shen

¹State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, People's Republic of China

,

Yi Hu

¹State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, People's Republic of China

› Author Affiliations

Abstract

Heterocyclic compounds are representative of a larger class of organic compounds, and worthy of attention for many reasons, chief of which is the participation of heterocyclic scaffolds in the skeleton structure of many drugs. Lipases are enzymes with catalytic versatility, and play a key role in catalyzing the reaction of carbon–carbon bond formation, allowing the production of different compounds. This article reviewed the lipase-catalyzed aldol reaction, Knoevenagel reaction, Michael reaction, Mannich reaction, etc., in the synthesis of several classes of heterocyclic compounds with important physiological and pharmacological activities, and also prospected the research focus in lipase-catalyzed chemistry transformations in the future.

Keywords

lipases - synthesis - heterocyclic compounds

Full Text

References

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