Subscribe to RSS
DOI: 10.1055/s-0041-1736308
Osteonecrosis of the Femoral Head: Update Article
Article in several languages: português | EnglishAbstract
Among the pathologies that affect the hip joint, osteonecrosis of the femoral head (ONFH) is probably the most intriguing and challenging. It consists of a multifactorial disease with a highly-variable spectrum in its clinical presentation. It has a devastating effect, due to disabling painful conditions, both for usual activities and sports. Given the huge range of risk factors, such as prolonged use of corticosteroids (especially in cases of rheumatologic diseases), trauma sequelae, sickle cell anemia, HIV, alcoholism, smoking, blood dyscrasias, and several other diseases that compromise the blood supply to the femoral head, ONFH has a varied clinical presentation and prognosis, which makes it difficult to determine a specific treatment, especially in cases in which chondral involvement has not yet occurred and the hip joint is still preserved. These are the main factors found in the literature that determine the classifications of this pathology. The range of treatments includes several options for cases in which an attempt is made to save the joint: conservative treatment, traditional decompression and/or combined with some type of adjuvant treatment (homologous grafting, synthetic grafting, vascularized grafts, tantalum screws, and bone marrow aspirate injection), and, for cases in which there is already a subchondral fracture and/or collapse of the femoral head and/or a reduction in the joint space, femoral osteotomies or total hip arthroplasty are commonly performed.
Financial Support
There was no financial support from public, commercial, or non-profit sources.
Work developed in the Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil.
Publication History
Received: 27 November 2020
Accepted: 18 May 2021
Article published online:
30 June 2022
© 2022. Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil
-
Referências
- 1 Fukushima W, Hirota Y. Alcohol. In: Koo K, Mont M, Jones L. editors. Osteonecrosis. Berlin: Springer; 2014: 95-99
- 2 Mont M, Zywiel M, Marker D. et al. The natural history of untreated osteonecrosis of the femoral head. J Bone Joint Surg Am 2010; 92 (12) 2165-2170
- 3 Shah KN, Racine J, Jones LC, Aaron RK. Pathophysiology and risk factors for osteonecrosis. Curr Rev Musculoskelet Med 2015; 8 (03) 201-209
- 4 Seamon J, Keller T, Saleh J, Cui Q. The pathogenesis of nontraumatic osteonecrosis. Arthritis (Egypt) 2012; 2012: 601763
- 5 Xu JL, Liang ZR, Xiong BL. et al. Risk factors associated with osteonecrosis of femoral head after internal fixation of femoral neck fracture:a systematic review and meta-analysis. BMC Musculoskelet Disord 2019; 20 (01) 632
- 6 Steppacher SD, Haefeli PC, Anwander H. et al. Traumatic avascular necrosis of the femoral head. In: Koo K, Mont M, Jones L. editors. Osteonecrosis. Berlin: Springer; 2014: 101-112
- 7 Hernigou P, Daltro G. Osteonecrosis in sicklecell disease. In: Koo K, Mont M, Jones L. editors. Osteonecrosis. Berlin: Springer; 2014: 125-131
- 8 Hernigou P, Habibi A, Bachir D, Galacteros F. The natural history of asymptomatic osteonecrosis of the femoral head in adults with sickle cell disease. J Bone Joint Surg Am 2006; 88 (12) 2565-2572
- 9 Tefferi A, Barbui T. Polycythemia vera and essential thrombocythemia: 2015 update on diagnosis, risk-stratification and management. Am J Hematol 2015; 90 (02) 162-173
- 10 Mont MA, Pivec R, Banerjee S, Issa K, Elmallah RK, Jones LC. High-Dose Corticosteroid Use and Risk of Hip Osteonecrosis: Meta-Analysis and Systematic Literature Review. J Arthroplasty 2015; 30 (09) 1506-1512.e5
- 11 Wang GJ, Cui Q, Balian G. The Nicolas Andry award. The pathogenesis and prevention of steroid-induced osteonecrosis. Clin Orthop Relat Res 2000; (370) 295-310
- 12 Wang Y, Li Y, Mao K, Li J, Cui Q, Wang GJ. Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin Orthop Relat Res 2003; (410) 213-224
- 13 Yoon BH, Mont MA, Koo KH. et al. The 2019 Revised Version of Association Research Circulation Osseous Staging System of Osteonecrosis of the Femoral Head. J Arthroplasty 2020; 35 (04) 933-940
- 14 Gold EW, Cangemi PJ. Incidence and pathogenesis of alcohol-induced osteonecrosis of the femoral head. Clin Orthop Relat Res 1979; (143) 222-226
- 15 Sella EMC, Carvalho MRP, Sato EI. Osteonecrose em pacientes com lúpus eritematoso sistêmico. Rev Bras Reumatol 2005; 45 (01) 1-8
- 16 Yoo JJ. Autoimmune disease and other risk factors. In: Koo K, Mont M, Jones L. editors. Osteonecrosis. Berlin: Springer; 201. 133-139
- 17 Sharareh B, Schwarzkopf R. Dysbaric osteonecrosis: a literature review of pathophysiology, clinical presentation, and management. Clin J Sport Med 2015; 25 (02) 153-161
- 18 Borges ÁH, Hoy J, Florence E. et al; for EuroSIDA. Antiretrovirals, fractures, and osteonecrosis in a large international HIV cohort. Clin Infect Dis 2017; 64 (10) 1413-1421
- 19 Guyton JL. Hip pain in the young adulkt and hip preservation surgery. In: Azar FM, Beaty J, Canale ST. editors. Campbell's Operative Orthopaedics. 13th ed.. Philadelphia: Editora Mosby / Elsevier; 2017: 378
- 20 Zeng J, Zeng Y, Wu Y, Liu Y, Xie H, Shen B. Acetabular Anatomical Parameters in Patients With Idiopathic Osteonecrosis of the Femoral Head. J Arthroplasty 2020; 35 (02) 331-334
- 21 Pierce TP, Jauregui JJ, Cherian JJ, Elmallah RK, Mont MA. Imaging evaluation of patients with osteonecrosis of the femoral head. Curr Rev Musculoskelet Med 2015; 8 (03) 221-227
- 22 Mont MA, Marulanda GA, Jones LC. et al. Systematic analysis of classification systems for osteonecrosis of the femoral head. J Bone Joint Surg Am 2006; 88 (Suppl. 03) 16-26
- 23 Ficat RP. Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment. J Bone Joint Surg Br 1985; 67 (01) 3-9
- 24 Steinberg ME, Steinberg DR. Classification systems for osteonecrosis: an overview. Orthop Clin North Am 2004; 35 (03) 273-283 , vii–viii
- 25 Ha YC, Jung WH, Kim JR, Seong NH, Kim SY, Koo KH. Prediction of collapse in femoral head osteonecrosis: a modified Kerboul method with use of magnetic resonance images. J Bone Joint Surg Am 2006; 88 (Suppl. 03) 35-40
- 26 Kim-Orden M, Barret K, Khatod M. Algorithm for treatment of hip and knee osteonecrosis: review and Presentation of three examples cases. J Rheum Dis Treat 2017; 3 (03) 053 Disponível em: https://clinmedjournals.org/articles/jrdt/journal-of-rheumatic-diseases-and-treatment-jrdt-3-053.php?jid=jrdt
- 27 Larson E, Jones LC, Goodman SB, Koo KH, Cui Q. Early-stage osteonecrosis of the femoral head: where are we and where are we going in year 2018?. Int Orthop 2018; 42 (07) 1723-1728
- 28 Mont MA, Cherian JJ, Sierra RJ, Jones LC, Lieberman JR. Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today? A Ten-Year Update. J Bone Joint Surg Am 2015; 97 (19) 1604-1627
- 29 Choi HR, Steinberg MEY. Y Cheng E. Osteonecrosis of the femoral head: diagnosis and classification systems. Curr Rev Musculoskelet Med 2015; 8 (03) 210-220
- 30 Zalavras CG, Lieberman JR. Osteonecrosis of the femoral head: evaluation and treatment. J Am Acad Orthop Surg 2014; 22 (07) 455-464
- 31 Banerjee S, Issa K, Pivec R, Kapadia BH, Khanuja HS, Mont MA. Osteonecrosis of the hip: treatment options and outcomes. Orthop Clin North Am 2013; 44 (04) 463-476
- 32 Wang CJ, Wang FS, Huang CC, Yang KD, Weng LH, Huang HY. Treatment for osteonecrosis of the femoral head: comparison of extracorporeal shock waves with core decompression and bone-grafting. J Bone Joint Surg Am 2005; 87 (11) 2380-2387
- 33 Al-Jabri T, Tan JYQ, Tong GY. et al. The role of electrical stimulation in the management of avascular necrosis of the femoral head in adults: a systematic review. BMC Musculoskelet Disord 2017; 18 (01) 319
- 34 Li W, Ye Z, Wang W, Wang K, Li L, Zhao D. Clinical effect of hyperbaric oxygen therapy in the treatment of femoral head necrosis : A systematic review and meta-analysis. Orthopade 2017; 46 (05) 440-446
- 35 Kaneshiro Y, Oda Y, Iwakiri K. et al. Low hepatic cytochrome P450 3A activity is a risk for corticosteroid-induced osteonecrosis. Clin Pharmacol Ther 2006; 80 (04) 396-402
- 36 Wang Y, Yin L, Li Y, Liu P, Cui Q. Preventive effects of puerarin on alcohol-induced osteonecrosis. Clin Orthop Relat Res 2008; 466 (05) 1059-1067
- 37 Yuan HF, Guo CA, Yan ZQ. The use of bisphosphonate in the treatment of osteonecrosis of the femoral head: a meta-analysis of randomized control trials. Osteoporos Int 2016; 27 (01) 295-299
- 38 Li D, Yang Z, Wei Z, Kang P. Efficacy of bisphosphonates in the treatment of femoral head osteonecrosis: A PRISMA-compliant meta-analysis of animal studies and clinical trials. Sci Rep 2018; 8 (01) 1450
- 39 Glueck C, Freiberg R, Wang P. Treatment of osteonecrosis of the hip and knee with enoxaparin. In: Koo K, Mont M, Jones L. editors. Osteonecrosis. Berlin: Springer; 2014: 241-247
- 40 Cao F, Liu G, Wang W. et al. Combined treatment with an anticoagulant and a vasodilator prevents steroid-associated osteonecrosis of rabbit femoral heads by improving hypercoagulability. BioMed Res Int 2017; 2017: 1624074
- 41 Song Q, Ni J, Jiang H, Shi Z. Sildenafil improves blood perfusion in steroid-induced avascular necrosis of femoral head in rabbits via a protein kinase G-dependent mechanism. Acta Orthop Traumatol Turc 2017; 51 (05) 398-403
- 42 Kandil A, Cui Q. Lipid-lowering agents and their effects on osteonecrosis: pros and cons. In: Koo K, Mont M, Jones L. editors. Osteonecrosis. Berlin: Springer; 2014: 255-259
- 43 Cui Q, Wang GJ, Su CC, Balian G. The Otto Aufranc Award. Lovastatin prevents steroid induced adipogenesis and osteonecrosis. Clin Orthop Relat Res 1997; (344) 8-19
- 44 Pritchett JW. Statin therapy decreases the risk of osteonecrosis in patients receiving steroids. Clin Orthop Relat Res 2001; (386) 173-178
- 45 Wang C, Sun W, Ling S. et al. AAV-Anti-miR-214 Prevents Collapse of the Femoral Head in Osteonecrosis by Regulating Osteoblast and Osteoclast Activities. Mol Ther Nucleic Acids 2019; 18: 841-850
- 46 Miyahara HS, Rosa BB, Hirata FY, Gurgel HMC, Ejnisman L, Vicente JRN. What is the role of core decompression in the early stages of osteonecrosis of the femoral head? Evaluation of the surgical result by functional score and radiological follow-up. Rev Bras Ortop 2018; 53 (05) 537-542
- 47 Mont MA, Carbone JJ, Fairbank AC. Core decompression versus nonoperative management for osteonecrosis of the hip. Clin Orthop Relat Res 1996; (324) 169-178
- 48 Pierce TP, Jauregui JJ, Elmallah RK, Lavernia CJ, Mont MA, Nace J. A current review of core decompression in the treatment of osteonecrosis of the femoral head. Curr Rev Musculoskelet Med 2015; 8 (03) 228-232
- 49 Hernigou P, Beaujean F. Treatment of osteonecrosis with autologous bone marrow grafting. Clin Orthop Relat Res 2002; (405) 14-23
- 50 Millikan PD, Karas V, Wellman SS. Treatment of osteonecrosis of the femoral head with vascularized bone grafting. Curr Rev Musculoskelet Med 2015; 8 (03) 252-259
- 51 Pierce TP, Elmallah RK, Jauregui JJ, Poola S, Mont MA, Delanois RE. A current review of non-vascularized bone grafting in osteonecrosis of the femoral head. Curr Rev Musculoskelet Med 2015; 8 (03) 240-245
- 52 Cao L, Guo C, Chen J, Chen Z, Yan Z. Free Vascularized Fibular Grafting Improves Vascularity Compared With Core Decompression in Femoral Head Osteonecrosis: A Randomized Clinical Trial. Clin Orthop Relat Res 2017; 475 (09) 2230-2240
- 53 Cui Q, Botchwey EA. Emerging ideas: treatment of precollapse osteonecrosis using stem cells and growth factors. Clin Orthop Relat Res 2011; 469 (09) 2665-2669
- 54 Daltro GC, Fortuna VA, Araújo MAS, Lessa PIF, Sobrinho UAB, Borojevic R. Femoral head necrosis treatment with autologous stem cells in sickle cell disease. Acta Ortop Bras. [serial on the Internet] 2008; 16 (01) 23-27 . Available from URL: http://www.scielo.br/aob
- 55 Houdek MT, Wyles CC, Collins MS. et al. Stem cells combined with platelet-rich plasma effectively treat corticosteroid-induced osteonecrosis of the hip: a prospective study. Clin Orthop Relat Res 2018; 476 (02) 388-397
- 56 Xu S, Zhang L, Jin H. et al. Autologous stem cells combined core decompression for treatment of avascular necrosis of the femoral head: a systematic review. BioMed Res Int 2017; 2017: 6136205
- 57 Onggo JR, Nambiar M, Onggo JD, Tay G, Singh PJ, Babazadeh S. Outcome of tantalum rod insertion in the treatment of osteonecrosis of the femoral head with minimum follow-up of 1 year: a meta-analysis and systematic review. J Hip Preserv Surg 2020; 7 (02) 329-339
- 58 Utsunomiya T, Motomura G, Ikemura S, Hamai S, Fukushi JI, Nakashima Y. The Results of Total Hip Arthroplasty After Sugioka Transtrochanteric Anterior Rotational Osteotomy for Osteonecrosis. J Arthroplasty 2017; 32 (09) 2768-2773
- 59 Maguire N, Robertson B, Henman P. Girdlestone procedure for avascular necrosis of the hip in an intravenous drug user. J Surg Case Rep 2014; 2014 (08) rju039
- 60 Pierce TP, Elmallah RK, Jauregui JJ, Verna DF, Mont MA. Outcomes of total hip arthroplasty in patients with osteonecrosis of the femoral head-a current review. Curr Rev Musculoskelet Med 2015; 8 (03) 246-251