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CC BY 4.0 · Eur J Dent 2022; 16(02): 266-273
DOI: 10.1055/s-0041-1736330
Review Article

Cyberknife Radiosurgery for the Treatment of Head and Neck Cancer: A Systematic Review

Cristalle Soman 
1   Department of Oral Medicine and Maxillofacial Radiology, Riyadh Elm University, Riyadh, Saudi Arabia
,
Shahad Ramzi Mohammed Alghamdi
2   College of Dentistry, Riyadh Elm University, Riyadh, Saudi Arabia
,
Faisal Nahar M. Alazemi
3   College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
,
Abdulaziz Ahmad Abdullah Alghamdi
3   College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
› Institutsangaben Funding None.
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Abstract

Cyberknife radiosurgery is a frameless stereotactic robotic radiosurgery which has shown to deliver better treatment outcomes in the treatment of advanced head and neck (H&N) carcinomas, especially in previously irradiated and recurrent cases. The aim of the study was to perform a systematic review of the available data on the outcomes of Cyberknife radiosurgery for treatment of head and neck cancer and to evaluate its collective outcomes. This systematic review was registered with the university with the registration no. FRP/2019/63 and was approved by the Institutional Review Board (RC/IRB/2019/132). Literature search was performed in the following: PubMed, Science direct, SciELO, MyScienceWork, Microsoft Academ EMBASE, Directory of Open Access Journals, and Cochrane databases with the keywords “Cyberknife,” “oral cancer,” “oropharyngeal cancer,” and “head and neck cancer” and data was extracted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The records identified were 147 manuscripts. Excluded articles included 5 duplicate articles, 33 abstracts, 101 full text articles due to being off-topic, case reports, review, non-English, 1 survey, and 2 other articles containing data extracted from a main study which was already included. A total of 5 articles were evaluated for qualitative synthesis. The mean dose of Cyberknife radiosurgery delivered for previously irradiated recurrent H&N carcinoma patients was 34.57 Gy, with a mean sample size of 5 studied during the period of 2000 to 2016. The available evidence from the systematic review indicates that Cyberknife can be an efficacious treatment option for recurrent previously irradiated H&N carcinoma, especially for nonresectable tumors. There is paucity of homogenous data and studies in this arena; hence, meta-analysis could not be performed. Further standardized studies are essential, especially where the treatment of H&N carcinoma is considered.

Keywords

cyberknife radiosurgery - oropharyngeal neoplasms - treatment outcomes of cyberknife - cyberknife radiotherapy - head and neck neoplasm - targeted radiation therapy - stereotactic radiotherapy - robotic radiosurgery

Note

The manuscript was available as a “preprint” in SSRN, formerly known as Social Science Research Network, and Lancet oncology which is both a repository for preprints and international journal devoted to the rapid dissemination of scholarly research.


Authors' Contributions

C.S., S.R.M.A., F.N.M.A., and A.A.A.A. were part of the project management group. C.S. contributed to conception, design, data acquisition and interpretation as well as drafting and critically revising the manuscript. S.R.M.A. contributed to data acquisition and analysis and critically revised the manuscript. F.N.M.A. contributed to data acquisition and analysis and critically revised the manuscript. A.A.A.A. contributed to data acquisition and analysis and critically revised the manuscript. All authors gave their final approval and agreed to be accountable for all aspects of the work, ensuring integrity and accuracy of the study.




Publikationsverlauf

Artikel online veröffentlicht:
10. Dezember 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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