Urinary Chloride Excretion Postcardiopulmonary Bypass in Pediatric Patients—A Pilot Study

Sophie Fincher; Kristen Gibbons; Kerry Johnson; Peter Trnka; Adrian C. Mattke

doi:10.1055/s-0041-1736549

Journal of Pediatric Intensive Care, Inhaltsverzeichnis

J Pediatr Intensive Care 2024; 13(01): 080-086
DOI: 10.1055/s-0041-1736549

Original Article

Urinary Chloride Excretion Postcardiopulmonary Bypass in Pediatric Patients—A Pilot Study

Autor*innen

Sophie Fincher

¹Department of Pediatric Intensive Care, Queensland Children's Hospital, Brisbane, Australia

²Pediatric Critical Care Research Group, Brisbane, Australia
Kristen Gibbons

²Pediatric Critical Care Research Group, Brisbane, Australia

³Child Health Research Centre, The University of Queensland, Brisbane, Australia
Kerry Johnson

¹Department of Pediatric Intensive Care, Queensland Children's Hospital, Brisbane, Australia

²Pediatric Critical Care Research Group, Brisbane, Australia

³Child Health Research Centre, The University of Queensland, Brisbane, Australia
Peter Trnka

⁴School of Medicine, The University of Queensland, Brisbane, Australia

⁵Queensland Child and Adolescent Renal Service, Queensland Children's Hospital, Brisbane, Australia
Adrian C. Mattke

¹Department of Pediatric Intensive Care, Queensland Children's Hospital, Brisbane, Australia

²Pediatric Critical Care Research Group, Brisbane, Australia

³Child Health Research Centre, The University of Queensland, Brisbane, Australia

⁴School of Medicine, The University of Queensland, Brisbane, Australia

Abstract

The aim of this study was to describe renal chloride metabolism following cardiopulmonary bypass (CPB) surgery in pediatric patients. A prospective observational trial in a tertiary pediatric intensive care unit (PICU) with 20 recruited patients younger than 2 years following CPB surgery was conducted. Urinary electrolytes, plasma urea, electrolytes, creatinine, and arterial blood gases were collected preoperatively, on admission to PICU and at standardized intervals thereafter. The urinary and plasma strong ion differences (SID) were calculated from these results at each time point. Fluid input and output and electrolyte and drug administration were also recorded. Median chloride administration was 67.7 mmol/kg over the first 24 hours. Urinary chloride (mmol/L; median interquartile range [IQR]) was 30 (19, 52) prior to surgery, 15 (15, 65) on admission, and remained below baseline until 24 hours. Plasma chloride (mmol/L; median [IQR]) was 105 (98, 107) prior to surgery and 101 (101, 106) on admission to PICU. It then increased from baseline, but remained within normal limits, for the remainder of the study. The urinary SID increased from 49.8 (19.1, 87.2) preoperatively to a maximum of 122.7 (92.5, 151.8) at 6 hours, and remained elevated until 48 hours. Plasma and urinary chloride concentrations were not associated with the development of acute kidney injury. Urinary chloride excretion is impaired after CPB. The urinary SID increase associated with the decrease in chloride excretion suggests impaired production and/or excretion of ammonium by the nephron following CPB, with gradual recovery postoperatively.

Keywords

acidosis/urine - chloride/urine - children - cardiac surgery - electrolytes

Volltext

Referenzen

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