Osteologie 2021; 30(04): 335-336
DOI: 10.1055/s-0041-1736714
Abstract

Single cell RNA sequencing identifies mitochondrial respiration as a key factor contributing to extracellular matrix integrity

Authors

  • K Bubb

    1   Department of Pediatrics and Adolescent Medicine, Experimental Neonatology, Medical Faculty, University of Cologne, Cologne, Germany and Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany

  • T Holzer

    1   Department of Pediatrics and Adolescent Medicine, Experimental Neonatology, Medical Faculty, University of Cologne, Cologne, Germany and Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany

  • J L Nolte

    2   Institute of Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany

  • M Krüger

    2   Institute of Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany

  • R Wilson

    3   Central Science Laboratory, University of Tasmania, Hobart, TAS 7005, Australia   ;

  • U Schlötzer-Schrehardt

    4   Department of Ophthalmology, University Hospital Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany

  • J Brinckmann

    5   Department of Dermatology, Institute of Virology and Cell Biology, University of Lübeck, Lübeck, Germany

  • J Altmüller

    6   Cologne Center for Genomics, University of Cologne, Cologne, Germany

  • A Aszodi

    7   Department of General, Trauma and Reconstructive Surgery, Munich University Hospital, Ludwig-Maximilians-University, Munich, Germany

  • L Fleischhauer

    7   Department of General, Trauma and Reconstructive Surgery, Munich University Hospital, Ludwig-Maximilians-University, Munich, Germany
    8   Center for Applied Tissue Engineering and Regenerative Medicine, Munich University of Applied Sciences, Munich, Germany

  • H Clausen-Schaumann

    8   Center for Applied Tissue Engineering and Regenerative Medicine, Munich University of Applied Sciences, Munich, Germany

  • K Probst

    1   Department of Pediatrics and Adolescent Medicine, Experimental Neonatology, Medical Faculty, University of Cologne, Cologne, Germany and Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany

  • B Brachvogel

    1   Department of Pediatrics and Adolescent Medicine, Experimental Neonatology, Medical Faculty, University of Cologne, Cologne, Germany and Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
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Introduction

During endochondral ossification, chondrocytes are in need of constant energy supply to maintain proliferation and matrix deposition. Mitochondrial respiration is one of the major cellular energy source and is described to drive postnatal growth, but the importance for extracellular matrix (ECM) homeostasis is poorly understood.



Publication History

Article published online:
04 November 2021

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