Osteologie 2021; 30(04): 337
DOI: 10.1055/s-0041-1736718
Abstract

Femoral cortical bone from type 1 diabetes mellitus individuals exhibit impaired osteocyte viability in the periosteal region

S Kolibova
1   University Medical Center Hamburg Eppendorf, Department of Osteology and Biomechanics, Hamburg, Germany
,
E M Wölfel
1   University Medical Center Hamburg Eppendorf, Department of Osteology and Biomechanics, Hamburg, Germany
,
H Hemmatian
1   University Medical Center Hamburg Eppendorf, Department of Osteology and Biomechanics, Hamburg, Germany
,
H Mushumba
2   University Medical Center Hamburg Eppendorf, Department of Forensic Medicine, Hamburg, Germany
,
B Wulff
2   University Medical Center Hamburg Eppendorf, Department of Forensic Medicine, Hamburg, Germany
,
K Püschel
2   University Medical Center Hamburg Eppendorf, Department of Forensic Medicine, Hamburg, Germany
,
B Busse
1   University Medical Center Hamburg Eppendorf, Department of Osteology and Biomechanics, Hamburg, Germany
,
K Jähn-Rickert
1   University Medical Center Hamburg Eppendorf, Department of Osteology and Biomechanics, Hamburg, Germany
› Author Affiliations
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Introduction

Type 1 diabetes mellitus (T1DM) patients have an up to 7-fold higher hip fracture risk compared to healthy individuals. The underlying mechanism of impaired bone quality in T1DM is unknown. Osteocytes play a pivotal role in mechanosensation and maintain skeletal homeostasis. Micropetrosis is osteocyte-lacuna mineralisation indicating previous osteocyte death and can delimit the lacuno-canalicular network, possibly resulting in changes in bone quality contributing to increased bone fragility in T1DM.



Publication History

Article published online:
04 November 2021

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