Cell-cell communication between chondrocytes and osteoblasts through miR-221-3p loaded extracellular vesicles

Introduction

Osteoarthritis (OA) is considered as a whole joint disease. The close physical association between subchondral bone and cartilage suggests the existence of biochemical and molecular crosstalk across the bone-cartilage interface, which may even be elevated in OA [1] [2]. miR-221-3p was demonstrated to be mechanosensitive in cartilage chondrocytes and extracellular vesicles (EVs) have been deeply researched for a specific role in cell-cell communication [3] [4] [5]. The present study is to investigate the communication between chondrocytes and osteoblasts through miR-221-3p transferred via EVs.

Publication History

Article published online:
04 November 2021

• References

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• 2 Yuan et al. Osteoarthritis Cartilage 2014; 22: 1077–1089
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• 4 Hecht et al. Osteoarthritis Cartilage 2019; 27: 1208–1218
• 5 Mohd Noor et al. Cells 2021; 10: 1–22