Plectranthus spp. and their secondary metabolites for dermatological disorders treatment

Many skin disorders such as hyperpigmentation, sagging and skin-aging have been linked to oxidative stress, resulting in an increased need of searching less cytotoxic, more powerful and safe alternative antioxidants with simultaneous cooperative activities.

This study represents a primary evaluation of Plectranthus spp. (Lamiaceae family) extracts and their isolated compounds as potential antioxidant agents capable of inhibiting the skin-related enzymes tyrosinase, collagenase and elastase, for the synergistic treatment of skin disorders.

Organic and aqueous extracts of Plectranthus spp. were obtained by microwave-assisted extraction method; their isolated compounds were screened and characterised by our team. Their in vitro antioxidant activity was tested using the DPPH activity assay. The anti-tyrosinase, anti-collagenase and anti-elastase was based on spectrophotometric methods.

The results showed that the antioxidant and enzyme inhibitor activities of the tested extracts can be explained by their main diterpenoid compounds such as 6,7-dihydroxyroyleanone and Parvifloron D.

Considering the obtained results, some studied Plectranthus extracts and their constituents represent promising bioactive agents with strong potential for cosmetic and/or pharmaceutical formulations in dermatology area.

Publication History

Article published online:
13 December 2021