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Synthesis 2022; 54(09): 2258-2266
DOI: 10.1055/s-0041-1737341
DOI: 10.1055/s-0041-1737341
paper
DMSO-Mediated Difunctionalization of Electron-Deficient Olefins to Access β-Hydroxysulfides with High Chemoselectivity
We are grateful for financial support from the National Natural Science Foundation of China (21702197), Anhui Agricultural University (yj2018-45), and Graduate Innovation Fund of Anhui Agricultural University (2021yjs-32).
Abstract
A novel and convenient method for the highly chemoselective synthesis of β-hydroxysulfides mediated by DMSO is reported. This eco-friendly reaction was amenable to a broad range of substrates and provided the desired β-hydroxysulfides in moderate to good yields with high selectivity via radical process. Moreover, several pharmaceutical and bioactive molecules were also suitable substrates for this reaction conditions to afford the targeted products in good yields.
Key words
β-hydroxysulfides - chemoselective synthesis - electron-deficient alkenes - radical process - air atmosphereSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0041-1737341.
- Supporting Information
Publikationsverlauf
Eingereicht: 24. November 2021
Angenommen nach Revision: 16. Dezember 2021
Artikel online veröffentlicht:
09. Februar 2022
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